1. The role of prostaglandins for the tissue cell dependent activation of dendritic cells. P. Ambrus, J. von der Ohe, E. Sowa, H. H. Radeke. Hannover Medical School, Germany. Immunobiol., 203:565, 2000.
2. Kinetics of Cellular Immune Responses During the Early Phase of IFN+Ribavirin Therapy of Chronic Hepatitis C Infection. Liermann H, Cornberg M, Kezmic N, Tegtmeyer B , Radeke H.H., Manns MP, Wedemeyer H.. Hannover Medical School, Germany. Journal of Hepatology; 34: S155, 2001.
3. Evaluation With Enzyme-Linked Immunosorbent Assay Spot Detection of the Frequency of Interferon-Gamma-Producing T Cells in Bronchoalveolar Lavage is Useful in Identifying Lung Transplant Patients at Higher Risk of Acute Rejection. F. Meloni, E. Paschetto, A. Cascina, A. Marone Bianco, C. Pellegrini, T. Oggionni, P. Vitulo, and M. Vigano. University of Pavia, Italy. Transplantation Proceedings 2001, 33, 3286-3288.
4. Celiac Disease Association with CD8+ T Cell Responses: Identification of a Novel Gliadin-Derived HLA-A2-Restricted Epitope. Carmen Gianfrani, Riccardo Troncone, Patrizia Mugione, Elena Cosentini, Mariateresa De Pascale, Clementina Faruolo, Stefania Senger, Giuseppe Terrazzano, Scott Southwood, Salvatore Auricchio, and Alessandro Sette. Institute of Food Science and Technology Avellino, Italy. The Journal of Immunology, 2003, 170: 2719-2726.
5. Large Numbers of Dysfunctional CD8+ T Lymphocytes Bearing Receptors for a Single Dominant CMV Epitope in the Very Old. Qin Ouyang, Wolfgang M. Wagner, Anders Wikby, Steffen Walter, Geraldine Aubert, Anthony I. Dodi, Paul Travers and Graham Pawelec. University of Tuebingen, Germany. Journal of Clinical Immunology, Volume 23, Number 4/2003, 247-257.
6. Prostaglandins differentially regulate interleukin12/23 subunit (p40 and p35/p19) expression in murine dendritic cells. Stoidtner K., Herrero-San Juan M., Radeke H.H.. University of Frankfurt. Germany. Naunyn-Schmiedeberg’s Arch. of Pharmacol., 367:R82 (313), 2003.
7. Moderate Local and Systemic Respiratory Syncytial Virus-Specific T-Cell Responses Upon Mild or Subclinical RSV Infection. L. de Waal, L.P. Koopman, I.J. van Benten, A.H. Brandenburg, P.G.H. Mulder, R.L. de Swart, W.J. Fokkens, H.J. Neijens, and A.D.M.E. Osterhaus, Erasmus MC, Rotterdam, The Netherlands. Journal of Medical Virology 70:309-318 (2003).
8. Imbalance of TH1/TH2 Lymphocytes in Patients with Membranoproliferativr Glomerulonephritis Hepatitis-C related. Carmelo Libetta, Manuela Zucchi, Elena Gori, Vincenzo Sepe, Federica Meloni, Antonio Dal Canton. Nephrology, Dialysis and Transplantation, University and IRCCS Policlinico S. Matteo, Pavia, Italy. WN2003, June 11th 2003.
9. Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and Bypass of Preexisting Adenovirus Immunity. Ronald Vogels, et. al.. Grucell Holland BV, Leiden, Netherlands. The Journal of Immunology, Aug. 2003, 8263-8271.
10. Emergence of Ph negative clones in chronic myeloid leukemia (CML) patients in complete cytogenetic remission after therapy with imatinib mesylate (STI). Alessandro Gozzetti, Daniela Tozzuoli, Rosaria Crupi, Sara Gentili, Monica Bocchia, Donatella Raspadori, Francesco Lauria. University of Siena, Italy. European Journal of Haematology, Volume 71, Issue 4, Page 313-314, October 2003.
11. Identification of Early Secretory Antigen Target-6 Epitopes for the Immunodiagnosis of Active Tuberculosis. Donatella Vincenti, Stefania Carrara, Patrizia De Mori,Leopoldo P Pucillo, Nicola Petrosillo, Fabrizio Palmieri, Orlando Armignacco, Giuseppe Ippolito, Enrico Girardi, Massimo Amicosante and Delia Goletti. National Institute for Infectious Diseases, Rome, Italy. Molecular Medicine 2003 Mar–Apr; 9(3-4): 105-111.
12. An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Qin Ouyang, Wolfgang M. Wagner, Steffen Walter, Claudia A. Müller, Anders Wikby, Geraldine Aubert, Tatjana Klatt, Stefan Stevanovic, Tony Dodi and Graham Pawelec. University of Tuebingen, Germany. Mechanisms of Ageing and Development, Volume 124, Issue 4, April 2003, Pages 477-485.
13. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1) . Qin Ouyang, Wolfgang M. Wagner, David Voehringer, Anders Wikby, Tatjana Klatt, Steffen Walter, Claudia A. Müller, Hanspeter Pircher and Graham Pawelec. University of Tuebingen, Germany. Experimental Gerontology, Volume 38, Issue 8, August 2003, Pages 911-920.
14. HIV-1 Tat Protein Modulates the Generation of Cytotoxic T Cell Epitopes by Modifying Proteasome Composition and Enzymatic Activity. Riccardo Gavioli, Eleonora Gallerani, Cinzia Fortini, Mariana Fabris, Arianna Bottoni, Alessandro Canella, Angela Bonaccorsi, Mauro Mrastoni, Fabiola Micheletti, Aurelio Cafaro, Paolo Rimessi, Antonella Caputo and Barbara Ensoli. University of Ferrara and Istituto Superiore de Santiá, Rome, Italy. The Journal of Immunology 2004,173: 3838-3848.
15. Use of a T Cell-Base Assay for Monitoring Efficacy of Antituberculosis Therapy. Stefania Carrara, Donatella Vincenti, Nicola Petrosillo, Massiomo Amicosante, Enrico Giradi and Delia Goletti. University Tor Vergata, Rome, Italy. Clinical Infectious Diseases 2004; 38:754-6.
16. An adenoviral type 5 vector carrying a type 35 fiber as a vaccine vehicle: DC targeting, cross neutralization, and immunogenicity Olga J. A. E. Ophorsta, Stefan Kostensea, Jaap Goudsmita, Rik L. de Swartb, Sandra Verhaagha, Alexander Zakhartchoukc, Marja van Meijera, Mieke Sprangersa, Geert van Amerongenb, Selma Yükselb, Albert D. M. E. Osterhausb and Menzo J. E. Havenga. Crucell Holland BV, Leiden, The Netherlands. Vaccine 2004, Volume 22, Issues 23-24, Pages 3035-3044.
17. Long-term follow-up after successful interferon therapy of acute hepatitis C. Wiegand J, Jackel E, Cornberg M, Hinrichsen H, Dietrich M, Kroeger J, Fritsch WP, Kubitschke A, Aslan N, Tillmann HL, Manns MP, Wedemeyer H.. Hannover Medical School, Germany. HEPATOLOGY 2004 Vol. 40, No. 1, 98-107.
18. Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-secretion for adjuvant immunotherapy. Tobias Feuchtingera, Peter Langa, Klaus Hamprechtc, Michael Schumma, Johann Greila, Gerhard Jahnc, Dietrich Niethammera, Hermann Einseleb. University of Tuebingen, Germany. Experimental Hematology 2004, Volume 32, Issue 3, Pages 282-289.
19. Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients. Mireille T. M. Vossen, Mi-Ran Gent, Jean-Claude Davin, Paul A. Baars, Pauline M. E. Wertheim-van Dillen, Jan F. L. Weel, Marijke T. L. Roos, Debbie van Baarle, Jaap Groothoff, René A. W. van Lier and Taco W. Kuijpers. Academic Medical Center Amsterdam, The Netherlands. Transplantation International, Volume 17, Number 2/2004, 89-96.
20. Expansion of Peripheral CD8+ CD28- T.Cells in Response to Epstein-Barr Virus in Patients with Rheumatoid Arthritis. Tatjana Klatt, Qin Ouyang, Thomas Flad, Ina Koetter, Hans-Jörg Bühring, Hubert Kalbacher, Graham Pawelec and Claudia A. Mueller. University of Tuebingen, Germany. The Journal of Rheumatology 2005; 32:239-51.
21. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. M. Bocchia, S. Gentili, E. Abruzzese, A. Fanelli, F. Iuliano, A. Tabilio, M. Amabile, F. Forconi, A. Gozzetti, D. Raspadori. University of Siena, Italy. The Lancet 2005, Volume 365, Issue 9460, Pages 657-662.
22. Enhancement of human papilloma virus type 16 E7 specific T cell responses by local invasive procedures in patients with (pre)malignant cervical neoplasia. Jeroen Visser, Debbie van Baarle, Baukje Nynke Hoogeboom, Nathalie Reesink, Harry Klip, Ed Schuuring, Esther Nijhuis, Michael Pawlita, Laura Bungener, Jacqueline de Vries-Idema, Hans Nijman, Frank Miedema, Toos Daemen, Ate van der Zee. International Journal of Cancer 2005, Volume 118, Issue 10, Pages 2529-2537.
23. Functional Constraints of Influenza A Virus Epitopes Limit Escape from Cytotoxic T Lymphocytes. E. G. M. Berkhoff, E. de Wit, M. M. Geelhoed-Mieras, A. C. M. Boom, J. Symons, R. A. M. Fouchier, A. D. M. E. Osterhaus and G. F. Rimmelzwaan. Erasmus Medical Center Rotterdam, The Netherlands. Journal of Virology, Sept. 2005, 11239-11246.
24. Recombinant human interleukon 10 suppresses gliadin dependent T cell activation in ex vivo cultured celiac intestinal mucosa. V M Salvati, G Mazzarella C C Gianfrani, M K Levings, R Steanile, B De Giulio G Laquinto, N Giardullo, S Auricchio, M G Roncarolo, R Troncone. University Federico II, Naples, CNR Avellino, San Raffaele Scientific Institute Milan, Hospital San Giuseppe Moscati, Avellino, Italy. Gut 2005;54:46-53.
25. Spontaneous resolution of chronic hepatitis C virus infection after antiviral treatment and relapse. Potthoff A, Sarhaddar J, Wiegand J, Lichtinghagen R, Sarrazin C, Ciner A, Hadem J, Trautwein C, Manns MP, Wedemeyer H.. Hannover Medical School, Germany. Hepatol. Res. Jan 2005, 31(1):18-23.
26. The Frequency of Interleukin-10- and Interleukin-5-Secreting CD4 T Cells Correlates to Tolerance of Transplanted Lung. Bianco, N. Solari, S. Miserere, C. Pellegrini, P. Vitulo, E. Pozzi, A. Fietta, F. Meloni. University of Pavia, Italy. Transplantation Proceedings 2005, Volume 37, Issue 5, Pages 2255-2256 A.
27. Antigen specific cytokine response in pediatric patients with atopic dermatitis. Valentina Bordignon , Jo Linda Sinagra, Elisabetta Trento, Mario Pietravalle, Bruno Capitanio and Paola Cordiali Fei. San Gallicano IRCCS, Rome, Italy. Pediatric Allergy and Immunology Volume 16 Issue 2 Page 113-120, March 2005.
28. Ex vivo evaluation of PPD-specific IFN- or IL-5 secreting cells in the peripheral blood and lungs of patients with tuberculosis. M. Morosini, F. Melonim, M. Uccelli, A. Marone Bianco, N. Solari, A.M. Fietta. University of Pavia, Italy. The International Journal of Tuberculosis and Lung Disease 2005, Volume 9, Number 7, 753-759.
29. Fast track selection of immunogens for novel vaccines through visualisation of the early onset of the B-cell response Antonio Scibelli, Robbert G. van der Most, Johan A. Turkstra, Mark P. Ariaans, Ger Arkesteijn, Evert J. Hensen and Rob H. Meloen. University of Utrecht, The Netherlands. Vaccine 2005, Volume 23, Issue 16, Pages 1900-1909.
30. Mass Tag-Assisted Identification of Naturally Processed HLA Class II-Presented Meningococcal Peptides Recognized by CD4+ T Lymphocytes. Hugo D. Meiring, Betsy Kuipers, Jacqueline A. M. van Gaans-van den Brink, Martien C. M. Poelen, Hans Timmermans, Gino Baart , Humphrey Brugghe, Joost van Schie, Claire J. P. Boog, Ad P. J. M. de Jong and Cécile A. C. M. van Els. N etherlands Vaccine Institute, Bilthoven, The Netherlands. The Journal of Immunology, 2005, 174: 5636-5643.
31. Direct Ex Vivo Detection of HLA-DR3 Restricted Cytomegalovirus- and Mycobacterium tuberculosis specific CD4+ T Cells. Corine Bronke, Nanette M. Palmer, Geertje H.A. Westerlaken, Mireille Toebes, Gijs M.W. van Schijndel, Veenu Purwaha, Krista E. van Meijgaarden, Ton N.M. Schumacher, Debbie van Baarle, Kiki Tesselaar and Annemieke Geluk. University of Amsterdam, The Netherlands. Human Immunology Volume 66, Issue 9, September 2005, Pages 950-961.
32. T cell epitope definition by differential mass spectrometry: Identification of a novel, immunogenic HLA-B8 ligand directly from renal cancer tissue. Thomas Flad, Ludmila Mueller, Hassan Dihazi, Veneta Grigorova, Ralf Bogumil, Alexander Beck, Cornelia Thedieck, Gerhard A. Mueller, Hubert Kalbacher, Claudia A. Mueller. University of Tuebingen and University of Goettingen, Germany. Proteomics, Volume 6, Issue 1 , Pages 364-374.
33. Identification of CD8+ T Cell Epitopes within Lytic Antigens of Human Herpes Virus8. Eliana Ribechini, Cinzia Fortini, Mauro Marastoni, Serena Traniello, Susanna Spisani, Paolo Monini and Ricardo Gavioli. University of Ferrara, Istituto Superiore di Sanitá Rome, Italy. The Journal of Immunology, 2006, 167:923-930.
34. DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination. Arianna Castaldello, Egidio Brocca-Cofano, Rebecca Voltan, Chiara Triulzi, Giuseppe Altavilla, Michele Laus, Katia Sparnacci, Marco Ballestri, Luisa Tondelli, Cinzia Fortini, Riccardo Gavioli, Barbara Ensoli and Antonella Caputo. University of Padova, Italy. Vaccine 2006, Volume 24, Issues 29-30, Pages 5655-5669.
35. CTL escape and increased viremia irrespective of HIV-specific CD4+ T-helper responses in two HIV-infected individuals. Mark J. Geels, Christine A. Jansen, Elly Baan, Iris M. De Cuyper, Gijs J.M. van Schijndel, Hanneke Schuitemaker, Jaap Goudsmit, Georgios Pollakis, Frank Miedema, William A. Paxton and Debbie van Baarle. University of Amsterdam, The Netherlands. Virology, Volume 345, Issue 1, 5 February 2006, Pages 209-219.
36. Identification of a cytotoxic T-lymphocyte (CTL) epitope recognized by Gag-specific CTLs in cynomolgus monkeys infected with simian/human immunodeficiency virus. Donatella R. M. Negri, Martina Borghi, Silvia Baroncelli, Iole Macchia, Viviana Buffa, Leonardo Sernicola, Pasqualina Leone, Fausto Titti and Andrea Cara. Istituto Superiore di Sanitá Rome, Italy. Journal of General Virolgy 87 (2006), 3385-3392.
37. Intradermal Delivery of Adenoviral Type-35 Vectors Leads to High Efficiency Transduction of Mature, CD8+ T Cell-Stimulating Skin-Emigrated Dendritic Cells. Tanja D. de Gruijl, Olga J. A. E. Ophorst, Jaap Goudsmi, Sandra Verhaagh, Sinéad M. Lougheed, Katarina Radosevic, Menzo J. E. Havenga and Rik J. Scheper. UMC Amtserdam and Crucell Holland BV Leiden, The Netherlands. The Journal of Immunology, 2006, 177: 2208-2215.
38. Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis. Ad Koets, Aad Hoek, Merel Langelaar, Marije Overdijk, Wiebren Santema, Peter Franken, Willem van Eden and Victor Rutten. University of Utrecht, The Netherlands. Vaccine 2006, Volume 24, Issue 14, Pages 2550-2559.
39. Gliadin-Specific Type 1 Regulatory T Cells from the Intestinal Mucosa of Treated Celiac Patients Inhibit Pathogenic T Cells. Carmen Gianfrani, Megan K. Levings, Claudia Sartirana, Giuseppe Mazzarella, Gianvincenzo Barba, Delia Zanz, Alessandra Camarca, Gaetano Iaquinto, Nicola Giardullo, Salvatore Auricchio, Riccardo Troncone and Maria-Grazia Roncarolo. Institute of Food Science, Avellino, Italy. The Journal of Immunology, 2006, 177: 4178-4186.
40. Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice. Daria Trabattoni, Alberto Clivio, Dorothy H. Bray, Lakshmi Bhagat, Silvia Beltrami, Giada Maffeis, Eugenio Cesana, Peter Lowry, Francesca Lissoni, Ekambar R. Kandimalla, Timothy Sullivan, Sudhir Agrawal, Richard Bartholomew and Mario Clerici. University of Milano, Italy. Vaccine 2006, Volume 24, Issue 9, Pages 1470-1477.
41. Generation of a novel replication-incompetent adenoviral vector derived from human adenovirus type 49: manufacture on PER.C6 cells, tropism and immunogenicity. Angelique A. C. Lemckert, Jos Grimbergen, Shirley Smits, Eric Hartkoorn, Lennart Holterman, Ben Berkhout, Dan H. Barouch, Ronald Vogels, Paul Quax, Jaap Goudsmit and Menzo J. E. Havenga. Crucell Holland BV and Gaubius Laboratory, Leiden, The Netherlands. Journal of General Virology 87 (2006), 2891-2899.
42. The Hypervariable Immunodominant NP418-426 Epitope from the Influenza A Virus Nucleoprotein Is Recognized by Cytotoxic T Lymphocytes with High Functional Avidity. Adrianus C. M. Boon, Gerrie de Mutsert, Ron A. M. Fouchier, Albert D. M. E. Osterhaus, and Guus F. Rimmelzwaan. Erasmus Medical Center Rotterdam, The Netherlands. Journal of Virology, June 2006, p. 6024-6032, Vol. 80, No. 12.
43. In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance. Brian D. Brown, Giovanni Sitia, Andrea Annoni, Ehud Hauben, Lucia Sergi Sergi, Anna Zingale, Maria Grazia Roncarolo, Luca G. Guidotti and Luigi Naldini. San Raffaele Scientific Institute Milan, Italy. Blood 2007, Vol. 109, No. 7, 2797-2805.
44. Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Frank Behrens, Andrea Himsel, Stefan Rehart, Joanna Stanczyk, Björn Beutel, Stefanie Y Zimmermann, Ulrike Koehl, Burkhard Möller, Steffen Gay, Joachim P Kaltwasser, Josef M Pfeilschifter, Heinfried H Radeke. J.W. Goethe University, Frankfurt/Main, Germany. Annals of the Rheumatic Diseases 2007;66:1151-1156.
45. Extracorporeal Photochemotherapy Is Accompanied by Increasing Levels of Circulating CD4+CD25+GITR+Foxp3+CD62L+ Functional Regulatory T-Cells in Patients With Graft-Versus-Host Disease. Biagi, Ettore; Di Biaso, Iolanda; Leoni, Veronica; Gaipa, Giuseppe; Rossi, Vincenzo; Bugarin, Cristina; Renoldi, Giuliano; Parma, Matteo; Balduzzi, Adriana; Perseghin, Paolo; Biondi, Andrea; University of Milan, Italy. Transplantation. 84(1):31-39, July 15, 2007.
46. HIV-1 Subtype C Gag-Specific T-Cell Responses in Relation to Human Leukocyte Antigens in a Diverse Population of HIV-Infected Ethiopians. Tsegaye, Aster; Ran, Leonie; Wolday, Dawit; Petros, Beyene; Dorigo, Wendelien; Piriou, Erwan; Messele, Tsehaynesh; Sanders, Eduard; Tilahun, Tesfaye; Eshetu, Deresse; Schuitemaker, Hanneke; Coutinho, Roel; Miedema, Frank; Borghans, Jose; Baarle, Debbie van. University of Amsterdam, The Netherlands. JAIDS Journal of Acquired Immune Deficiency Syndromes. 45(4):389-400, August 1, 2007.
47. Identification of a CD4 T cell epitope in the pneumonia virus of mice glycoprotein and characterization of its role in protective immunity. Erwin A.W. Claassen, Grada M. van Bleek, Zuzana S. Rychnavska, Raoul J. de Groot, Evert J. Hensen, Edwin J. Tijhaar, Willem van Eden and Robbert G. van der Most. University of Utrecht, The Netherlands. Virology 2007, Volume 368, Issue 1, Pages 17-25.
48. HCV-specific T-cell responses in injecting drug users: evidence for previous exposure to HCV and a role for CD4+ T cells focussing on nonstructural proteins in viral clearance. T. A. Ruys, N. M. Nanlohy, C. H. S. B. van den Berg, E., M. Beld, T. van de Laar, S. Bruisten, F. Wit, A. Krol, M. Prins, J. Lange, D. van Baarle. AMC Amsterdam and University of Utrecht, The Netherlands. Journal of Viral Hepatitis 1365-2893.2007.
49. Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice. J-P. Amorij, V. Saluja, A.H. Petersen, W.L.J. Hinrichs, A. Huckriede and H.W. Frijlink. University of Groningen, The Netherlands. Vaccine 2007, Volume 25, Issue 52, Pages 8707-8717.
50. The effect of sirolimus- or cyclosporine-based immunosuppression effects on T-cell subsets in vivo. C Libetta, V Sepe, M Zucchi, V Portalupi, F Meloni, T Rampino and A Dal Canton. University of Pavai, Italy. Kidney International (2007) 72, 114-120.
51. The Ag85B protein of Mycobacterium tuberculosis may turn a protective immune response induced by Ag85B-DNA vaccine into a potent but non-protective Th1 immune response in mice. Carla Palma, Elisabetta Iona, Federico Giannoni, Manuela Pardini, Lara Brunori, Graziella Orefici, Lanfranco Fattorini and Antonio Cassone. Istituto Superiore di Sanità, Rome, Italy. Cellular Microbiology Volume 9 Issue 6 Page 1455-1465, June 2007.
52. Generation of functional dendritic cells (DC) in adult acute lymphoblastic leukemia: rationale for a DC-based vaccination program for patients in complete hematological remission. Roberta Maggio; Nadia Peragine; Elisabetta Calabrese; Maria Stefania De Propris; Stefania Intoppa; Irene Della Starza; Cristina Ariola; Antonella Vitale; Robin Foà; Anna Guarini. University La Sapienza, Rome, Italy. Leukemia and Lymphoma, Volume 48, Issue 2 February 2007 , pages 302-310.
53. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia. Visser, J.; Nijman, H. W.; Hoogenboom, B.-N.; Jager, P.; van Baarle, D.; Schuuring, E.; Abdulahad, W.; Miedema, F.; van der Zee, A. G.; Daemen, T.. University Medical Center Groningen, The Netherlands. Clinical & Experimental Immunology, Volume 150, Number 2, November 2007, 199-209.
54. Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells. Ariadna Mendoza-Naranjo, Pablo J. Saéz, C. Christian Johansson, Marcos Ramírez, Dinka Mandakovic, Cristian Pereda, Mercedes N. López, Rolf Kiessling, Juan C. Sáez and Flavio Salazar-Onfray. University of Chile, Santiago, Chile. The Journal of Immunology, 2007, 178: 6949-6957.
55. Functional Up-regulation of Human Leukocyte Antigen Class I Antigens Expression by 5-aza-2'-deoxycytidine in Cutaneous Melanoma: Immunotherapeutic Implications. Ester Fonsatti, Hugues J.M. Nicolay, Luca Sigalotti, Luana Calabrò, Laura Pezzani, Francesca Colizzi, Maresa Altomonte, Massimo Guidoboni, Francesco M. Marincola and Michele Maio. University Hospital of Siena, Italy. Clinical Cancer Research 13, 3333-3338, June 1, 2007.
56. Viral Replication Capacity as a Correlate of HLA B57/B5801-Associated Nonprogressive HIV-1 Infection. Marjon Navis, Ingrid Schellens, Debbie van Baarle, José Borghans, Peter van Swieten, Frank Miedema, Neeltje Kootstra and Hanneke Schuitemaker. Sanquin Reagents, Amsterdam, The Netherlands. The Journal of Immunology, 2007, 179: 3133-3143.
57. Gliadin Regulates the NK-Dendritic Cell Cross-Talk by HLA-E Surface Stabilization. Giuseppe Terrazzano, Michela Sica, Carmen Gianfrani, Giuseppe Mazzarella, Francesco Maurano, Beatrice De Giulio, Sophie de Saint-Mezard, Delia Zanzi, Luigi Maiuri, Marco Londei, Bana Jabri, Riccardo Troncone, Salvatore Auricchio, Serafino Zappacosta and Ennio Carbone. University Federico II, Naples, Italy. The Journal of Immunology, 2007, 179: 372-381.
58. Progesterone sensitive Interferon-producing cells detected by ELISpot assay in autoimmune progesterone dermatitis. Cristaudo, A.; Bordignon, V.; Palamara, F.; De Rocco, M.; Pietravalle, M.; Picardo, M.. St. Gallicano Institute, Rome, Italy. Clinical & Experimental Dermatology, Volume 32, Number 4, July 2007, 439-441.
59. No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies. Janet W. de Beukelaar, Georges M. Verjans, Yvette van Norden, Johannes C. Milikan, Jaco Kraan, Herbert Hooijkaas, Kees Sintnicolaas, Jan W. Gratama and Peter A. Sillevis Smitt. Erasmus University Medical Center Rotterdam, The Netherlands. Cancer Immunology, Immunotherapy, Volume 56, Number 9/2007, 1501-1506.
60. Induction of hepatitis C virus (HCV)-specific T cells by needle stick injury in the absence of HCV-viraemia. A. Kubitschke, M. J. Bahr, N. Aslan, C. Bader, H. L. Tillmann, C. Sarrazin, T. Greten, J. Wiegand, M. P. Manns and H. Wedemeyer. Hannover Medical School, Germany. European Journal of Clinical Investigation, Volume 37, Issue 1 Page 54-64, January 2007.
61. Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response. Mascolo, Dina; Barba, Pasquale; De Berardinis, Piergiuseppe; Di Rosa, Francesca; Del Pozzo, Giovanna. CNR, Naples, Italy. FEMS Immunology & Medical Microbiology, Volume 50, Number 1, June 2007, 59-66.
62. Cyclophosphamide Enhances the Antitumor Efficacy of Adoptively Transferred Immune Cells through the Induction of Cytokine Expression, B-Cell and T-Cell Homeostatic Proliferation, and Specific Tumor Infiltration. Laura Bracci, Federica Moschella, Paola Sestili, Valentina La Sorsa, Mara Valentini, Irene Canini, Sara Baccarini, Sonia Maccari, Carlo Ramoni, Filippo Belardelli and Enrico Proietti. Istituto Superiore di Sanità, Rome, Italy. Clinical Cancer Research 13, 644-653, January 15, 2007.
63. Increase percentage of regulatory T cells is associated with advanced HIV disease and HIV-TB coinfection: a reflection of enhanced immune activation? Belete Tegbaru, Nening N. Nanlohy, Tsehaynesg Messele, Margreet Westerlaken, Mesfin Kebede, Mulu Girma, Ermias Hailu, Semere Yohannes, Yared Asmare, Dawit Wolday, Debbie van Baarle. Ethiopian Health and Nutrition Research Centre and University Medical Center Utrecht.
64. The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS. Riccardo Gaviol, Silvia Cellini, Arianna Castaldello, Rebecca Voltan, Eleonora Gallerani, Francesca Gagliardoni, Cinzia Fortini, Egidio Brocca Cofano, Chiara Triulzi, Aurelio Cafaro, Indresh Srivastava, Susan Barnett, Antonella Caputo and Barbara Ensoli. University of Ferrara, Italy. Vaccine 2008, Volume 26, Issue 5, Pages 727-737.
65. Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis. Elke Wiesemann, Milano Deb, Bernhard Hemmer, Heinfried H. Radeke and Anja Winhagen. Medical School Hannover, Technical University Munich, and Goethe University Frankfurt. Clinical Immunology 23. April 2008.
66. In vitro study of pro-inflammatory and anti-tumour properties of micro vesicles from bacterial cell wall of pantoea agglomerans. Radoslaw Spiewak, Jacek Dutkierwicz. Institute of Dermatology Ltd. Krakow and Institute of Agricultural Medicine, Lublin, Poland. Annals of Agricultural and Environmental Medicine 2008 15, 153-161.
67. Response to M. tuberculosis selected RDI peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study. Delia Goletti, Stefania Carrara. Harriet Mayanja-Kizza, Joy Baseke, Michael Angel Mugerwa, Enrico Girardi and Zahra Toossi. IRCCS Rome, Case Western University Cleveland Ohio and TBRU Kampala. BMC Infectious Diseases 2008, 8:11.
68. Humoral and Cellular Response to Influenza Vaccine in HIV-Infected Children With Full Viroimmunologic Response to Antiretroviral Therapy. Vigano, Alessandra MD; Zuccotti, Gian Vincenzo MD; Pacei, Michela BS; Erba, Paola MD; Castelletti, Eleonora BS; Giacomet, Vania MD ; Amendola, Antonella MD; Pariani, Elena BS; Tanzi, Elisabetta BS; Clerici, Mario MD. JAIDS Journal of Acquired Immune Deficiency Syndromes. 48(3):289-296, July 1, 2008.
69. T cell responses to hepatitis B surface antigen are detectable in non-vaccinated individuals. Martin R Weihrauch, Michael von Bergwelt-Baildon, Milos Kandic, Martin Weskott, Winfried Klamp, Joachim Rösler, Joachim L Schultze. University of Cologne. World J Gastroenterol 2008 April 28; 14(16): 2529-2533
70. Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: Impact of distinct additional adjuvants. Katarina Rado%u0161evi%u0107, Ariane Rodriguez, Ratna Mintardjo, Dennis Tax, Karin Lövgren Bengtsson, Catherine Thompson, Maria Zambon, Gerrit Jan Weverling, Fons UytdeHaag and Jaap Goudsmit. Crucell Holland BV, Leiden, The Netherlands, Isconova AB, Uppsala, Sweden, Health Protection Agency, London, United Kingdom, Center of Poverty-related Communicable Diseases, Academic Medical Center, Amsterdam, The Netherlands. J.Vaccine.2008.04.071.
71. Identification of new HIV-1 Gag-specific cytotoxic T lymphocyte responses in BALB/c mice.Silvia Cellini, Cinzia Fortini, Eleonora Gallerani, Federica Destro, Egidio Brocca Cofano, Antonella Caputo, and Riccardo Gavioli. Department of Biochemistry and Molecular Biology, University of Ferrara and Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Italy. Virol J. 2008; 5: 81.
72. Impact of Recombinant Adenovirus Serotype 35 Priming versus Boosting of a Plasmodium falciparum Protein: Characterization of T- and B-Cell Responses to Liver-Stage Antigen. Ariane Rodríguez, Jaap Goudsmit, Arjen Companjen, Ratna Mintardjo, Gert Gillissen, Dennis Tax, Jeroen Sijtsma, Gerrit Jan Weverling, Lennart Holterman, David E. Lanar, Menzo J. E. Havenga, and Katarina Radosevic. Crucell Holland BV Leiden, The Netherlands, Center of Poverty-Related Communicable Diseases, Academic Medical Center, Amsterdam, The Netherlands and Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland. Infection and Immunity, April 2008, p. 1709-1718, Vol. 76, No. 4.
73. Cross-Recognition of Avian H5N1 Influenza Virus by Human Cytotoxic T-Lymphocyte Populations Directed to Human Influenza A Virus. J. H. C. M. Kreijtz, G. de Mutsert, C. A. van Baalen, R. A. M. Fouchier, A. D. M. E. Osterhaus, and G. F. Rimmelzwaan. Department of Virology, Erasmus Medical Center Rotterdam, The Netherlands. Journal of Virology, June 2008, p. 5161-5166, Vol. 82, No. 11.
74. Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates. Babs E. Verstrepen, Adriaan D. Bins, Christine S. Rollier, Petra Mooij, Gerrit Koopman, Neil C. Sheppard, Quentin Sattentau, Ralf Wagner, Hans Wolf, Ton N.M. Schumacher, Jonathan L. Heeney and John B.A.G. Haanen. Department of Virology, Biomedical Primate Research Centre Rijswijk, The Netherlands, Division of Immunology, The Netherlands Cancer Institute Amsterdam, Sir William Dunn School of Pathology, University of Oxford, United Kingdom Institute of Medical Microbiology and Hygiene, Regensburg, Germany, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. J.Vaccine.2008.03.091.
75. Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. Valentina Bordignon, Francesca Palamara, Paola Cordiali-Fei, Antonella Vento, Arianna Aiello, Mauro Picardo, Fabrizio Ensoli and Antonio Cristaudo. Laboratory of Clinical Pathology, Department of Allergology and Laboratory of Skin Physiopathology, Institute San Gallicano, IRCCS, IFO, Rome, Italy. BMC Immunol. 2008; 9: 19.
76. Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic. Max Corbetta,b, Willy M. Bogersc, Jonathan L. Heeneyc, Stefan Gerberd, Christian Genine, Arnaud Didierlaurentf, Herman Oostermeijerc, Rob Dubbesc, Gerco Braskampc, Stéphanie Lerondelg, Carmen E. Gomezh, Mariano Estebanh, Ralf Wagneri, Ivanella Kondovac, Petra Mooijc, Sunita Balla-hagjhoorsinghj, Niels Beenhakkerc, Gerrit Koopmanc, Sjoerd van der Burgk, Jean-Pierre raehenbuhla,l,m, and Alain Le Papen. Proceeded 2008 by The National Academy of Sciences of the USA.
77. Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073. P. Fytili, G.N. Dalekos, V. Schlaphoff, P.V. Suneetha, C. Sarrazin, W. Zauner, K. Zachou, T. Berg, M.P. Manns, C.S. Klade, M. Cornberg and H. Wedemeyer. Medizinische Hochschule Hannover, Abt. Gastroenterologie, Hepatologie und Endokrinologie, Hannover, Germany, Department of Medicine, Academic Liver Unit and Research Lab of Internal Medicine, Medical School, University of Thessaly, Larissa, Greece, Intercell AG, Campus Vienna, Austria, Abt. Innere Medizin II, Saarland University Hospital, Homburg, Germany, Hepatology and Gastroenterology, Charité Campus Virchow-Klinikum, Berlin, Germany. J.Vaccine.2008.05.045.
78. STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation. Sean A. Diehl, Heike Schmidlin, Maho Nagasawa, Simon D. van Haren, Mark J. Kwakkenbos, Etsuko Yasuda, Tim Beaumont, Ferenc A. Scheeren and Hergen Spits. Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam; Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory and Van Creveld Laboratory; AIMM Therapeutics, B.V., Amsterdam, The Netherlands; and Genentech, Inc., San Francisco. The Journal of Immunology, 2008, 180: 4805-4815.
79. Development of Virus-Specific CD4+ T Cells on Reexposure to Varicella-Zoster Virus. Mireille T. M. Vossen, Mi-Ran Gent, Jan F. L. Weel, Menno D. de Jong, René A. W. van Lier and Taco W. Kuijpers. Academic Medical Center, Amsterdam, The Netherlands. The Journal of Infectious Diseases 2004;190:72–82.
80. Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 ΔV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin. Antonella Caputo, Egidio Brocca-Cofano, Arianna Castaldello, Rebecca Voltan, Riccardo Gavioli, Indresh K. Srivastava, Susan W. Barnett, Aurelio Cafaro and Barbara Ensoli. Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Italy; Department of Biochemistry and Molecular Biology, University of Ferrara, Italy; Novartis Vaccines, Emeryville, United States; National AIDS Center, Istituto Superiore di Sanità, Roma, Italy. J.Vaccine.2007.12.030.
81. Pretransplant Infusion of Mesenchymal Stem Cells Prolongs the Survival of a Semiallogeneic Heart Transplant through the Generation of Regulatory T Cells. Federica Casiraghi, Nadia Azzollini, Paola Cassis, Barbara Imberti Marina Morigi, Daniela Cugini, Regiane Aparecida Cavinato, Marta Todeschini, Samantha Solini, Aurelio Sonzogni, Norberto Perico, Giuseppe Remuzzi and Marina Noris. Transplant Research Center, "Chiara Cucchi De Alessandri & Gilberto Crespi," Ranica, Department of Medicine and Transplantation, Ospedali Riuniti, and Mario Negri Institute for Pharmacological Research, Bergamo, Italy. The Journal of Immunology, 2008, 181: 3933-3946.
82. Influence of 17β-oestradiol, nortestosterone and dexamethasone on the adaptive immune response in veal calves. Eisenberg , G . Cacciatore , S . Klarenbeek , A . Bergwerff , A . Koets. Faculty of Veterinary Medicine Utrecht University, The Netherlands. Research in Veterinary Science , Volume 84 , Issue 2 , Pages 199 – 205.
83. Mutation in the immunodominant epitope of the HPV16 E7 oncoprotein as a mechanism of tumor escape. Michal Smahel, Pavla Tejklova, Jana Smahelova, Ingrid Polakova and Jana Mackova. Department of Experimental Virology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic. Cancer Immunology, Immunotherapy Volume 57, Number 6 / Juni 2008.
84. HCV-specific T-cell responses in injecting drug users: evidence for previous exposure to HCV and a role for CD4+ T cells focussing on nonstructural proteins in viral clearance. T. A. Ruys, N. M. Nanlohy, C. H. S. B. van den Berg, E. Hassink, M. Beld, T. van de Laar, S. Bruisten, F. Wit, A. Krol, M. Prins, J. Lange and D. van Baarle. Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, International Antiviral Therapy and Evaluation Center (IATEC) and Academic Medical Center, Amsterdam ; Department of Immunology, University Medical Center Utrecht, Utrecht ; Cluster of Infectious diseases, Department of HIV and STI research, Municipal Health Service, Amsterdam ; and Department of Microbiology, Division of Virology, Academic Medical Center, Amsterdam, The Netherlands. Journal of Viral Hepatitis Volume 15 Issue 6, Pages 409 – 420.
85. Alum boosts TH2-type antibody responses to whole-inactivated virus influenza vaccine in mice but does not confer superior protection. Laura Bungener, Felix Geeraedts, Wouter ter Veer, Jeroen Medema, Jan Wilschut and Anke Huckriede. Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, The Netherlands Solvay Pharmaceuticals, Weesp, The Netherlands. J.Vaccine.2008.02.063
86. HIV-1-Specific T Cell Precursors with High Proliferative Capacity Correlate with Low Viremia and High CD4 Counts in Untreated Individuals. Sandra A. Calarota, Andrea Foli, Renato Maserat, Fausto Baldanti, Stefania Paolucci, Mary A. Young, Christos M. Tsoukas|, Julianna Lisziewicz and Franco Lori. Policlinico S. Matteo, Pavia, Italy; Georgetown University Medical Center, Washington; DC, McGill University Health Center, Montréal, Québec, Canada; and Genetic Immunity, Budapest, Hungary. The Journal of Immunology, 2008, 180: 5907-5915
87. The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-γ response. Carla Palma, Elisabetta Iona, Federico Giannoni, Manuela Pardini, Lara Brunori, Lanfranco Fattorini, Giuseppe Del Giudice and Antonio Cassone. Istituto Superiore di Sanità, Rome, Italy and Novartis Vaccines and Diagnostics Srl, Siena, Italy. J.Vaccine.2008.05.050
88. Gliadin Activates HLA Class I-Restricted CD8+ T Cells in Celiac Disease Intestinal Mucosa and Induces the Enterocyte Apoptosis. G. Mazzarella, R. Stefanile, A. Camarca, P. Giliberti, E. Cosentini, C. Marano, G. Laquinto, N. Giardullo, S. Auricchio, A. Sette. Gastroenterology , Volume 134 , Issue 4 , Pages 1017 – 1027.
89. Rational Design of a Multiepitope Vaccine Encoding T-Lymphocyte Epitopes for Treatment of Chronic Hepatitis B Virus Infections. Erik Depla, Annegret Van der Aa, Brian D. Livingston, Claire Crimi, Koen Allosery, Veronique De Brabandere, Jonathan Krakover, Sidharta Murthy, Manley Huang, Scott Power, Lilia Babé, Carol Dahlberg, Denise McKinney, Alessandro Sette, Scott Southwood, Ramilla Philip, Mark J. Newman and Lydie Meheus. GENimmune NV (Innogenetics NV), Ghent, Belgium, Pharmexa-Epimmune Inc., San Diego, California, Immunotope Inc., Doylestown, Pennsylvania, Danisco US Inc. (Genencor International Inc.), Rochester, New York. Journal of Virology, January 2008, p. 435-450, Vol. 82, No. 1.
90. ELISPOT and intracellular cytokine staining: Novel assays for quantifying T cell responses in the chicken. M.P. Ariaans, P.M. van de Haar, J.W. Lowenthal, W. van Eden, E.J. Hensen and L. Vervelde. Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, The Netherlands; Australian Animal Health Laboratory, CSIRO, Livestock Industries, Victoria, Australia. Developmental & Comparative Immunology Volume 32, Issue 11, 2008, Pages 1398-1404.
91. Renal Urokinase-Type Plasminogen Activator (uPA) Receptor but not uPA Deficiency Strongly Attenuates Ischemia Reperfusion Injury and Acute Kidney Allograft Rejection. Faikah Gueler, Song Rong, Michael Mengel, Joon-Keun Park, Julia Kiyan, Torsten Kirsch, Inna Dumler, Hermann Haller and Nelli Shushakova. Medical School Hannover and Phenos GmbH, Hannover, Germany. The Journal of Immunology, 2008, 181: 1179-1189.
92. Cyclin D1–Specific Cytotoxic T Lymphocytes Are Present in the Repertoire of Cancer Patients: Implications for Cancer Immunotherapy. Eisei Kondo, Britta Maecker, Martin R. Weihrauch, Claudia Wickenhauser, WanYong Zeng, Lee M. Nadler, Joachim L. Schultze and Michael S. von Bergwelt-Baildon. Molecular Tumour Biology and Tumour Immunology, University Hospital of Cologne, Germany. Clinical Cancer Research 14, 6574, October 15, 2008.
93. Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study. Delia Goletti, Stefania Carrara, Harriet Mayanja-Kizza, Joy Baseke, Michael Angel Mugerwa, Enrico Girardi and Zahra Toossi. 1Translational Research Unit, Department of Experimental Research, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani – IRCCS Rome, Italy; Case Western Reserve University, Department of Medicine, Division of Infectious Diseases, Cleveland, Ohio, USA; TBRU, Kampala, Uganda; Clinical Epidemiology Unit, Department of Experimental Research, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani – IRCCS Rome, Italy. BMC Infectious Diseases 2008, 8:11doi:10.1186/1471-2334-8-11
94. A Nonprogressive Clinical Course in HIV%u2010Infected Individuals Expressing Human Leukocyte Antigen B57/5801 Is Associated with Preserved CD8+ T Lymphocyte Responsiveness to the HW9 Epitope in Nef. Marjon Navis,Ingrid M. M. Schellens, Peter van Swieten, José A. M. Borghans, Frank Miedema, Neeltje A. Kootstra, Debbie van Baarle and Hanneke Schuitemaker. Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam at the Academic Medical Center, Amsterdam, and University Medical Center Utrecht and Theoretical Biology, Utrecht University, Utrecht The Netherlands. The Journal of Infectious Diseases 2008;197:871–879.
95. Interleukin-13 mucosal production in Helicobacter pylori-related gastric diseases. B. Marottia, A. Roccoa, P. De Colibusa, D. Comparea, G. de Nuccia, S. Staibanob, F. Tatangelod, M. Romanoc, G. Nardonea. Department of Clinical and Experimental Medicine, Gastroenterology Unit, University of Naples “Federico II”, Italy; Department of Biomorphological and Functional Sciences, Pathology Unit, University of Naples “Federico II”, Naples, Italy; Department of Medicine, Gastroenterology, Second University of Naples, Naples, Italy and Pathology Unit, Cancer Institute of Naples, Pascale Foundation, Italy. Digestive and Liver Disease April 2008 (Vol. 40, Issue 4, Pages 240-247).
96. Plant-produced potato virus X chimeric particles displaying an influenza virus-derived peptide activate specific CD8+ T cells in mice. References and further reading may be available for this article. To view references and further reading you must purchase this article. Chiara Lico, Camillo Mancini, Paola Italiani, Camilla Betti, Diana Boraschi, Eugenio Benvenuto and Selene Banchieri. ENEA C.R. Casaccia, Sezione Genetica e Genomica Vegetale, Via Anguillarese 301, 000123 Roma, Italy, Istituto di Tecnologie Biomediche, CNR, Area della Ricerca di S. Cataldo, Via Moruzzi 1, 56124 Pisa, Italy. Vaccine Volume 27, Issue 37, 13 August 2009, Pages 5069-5076.
97. Evaluation of a prime-boost vaccine schedule with distinct adenovirus vectors against malaria in rhesus monkeys. Ariane Rodríguez, Ratna Mintardjo, Dennis Tax, Gert Gillissen, Jerome Custers, Maria Grazia Pau, Jaco Klap, Sampa Santra, Harikrishnan Balachandran, Norman L. Letvin, Jaap Goudsmit and Katarina Rado%u0161evi%u0107. Crucell Holland BV, Leiden, The Netherlands; Center of Poverty-Related Communicable Diseases, Academic Medical Center, Amsterdam, The Netherlands; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States. Vaccine Volume 27, Issue 44, 19 October 2009, Pages 6226-6233.
98. Priming with a very low dose of DNA complexed with cationic block copolymers followed by protein boost elicits broad and long-lasting antigen-specific humoral and cellular responses in mice. Rebecca Voltan, Arianna Castaldello, Egidio Brocca-Cofano, Rita De Michele, Chiara Triulzi, Giuseppe Altavilla, Luisa Tondelli, Michele Laus, Katia Sparnacci, Eva Reali, Riccardo Gavioli, Barbara Ensoli and Antonella Caputo. Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Padova, Italy; Department of Medical-Diagnostic Sciences and Special Therapies, University of Padova, Padova, Italy; I.S.O.F., Consiglio Nazionale delle Ricerche, Bologna, Italy; Department of Life and Ambient Sciences, University of Piemonte Orientale and INSTM, UdR, Alessandria, Italy; Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy; National AIDS Center, Istituto Superiore di Sanità, Roma, Italy. Vaccine Volume 27, Issue 33, 16 July 2009, Pages 4498-4507.
99. A method of cross-priming CD8+ T cells to antigens using Dendritic Cells cultured in the presence of a type I Interferon and GM-CSF, and vaccines and methods of vaccination comprising said Dendritic Cells. Belardelli, Filippo (Rome, IT); Ferrantini, Maria (Rome, IT); Lapenta, Caterina (Florence, IT); Lattanzi, Laura (Rome, IT); Parlato, Stefania (Rome, IT); Santini, Stefano Maria (Rome, IT). United States Patent Application 20090041792, 02/12/2009.
100. Ncf1 Provides a Reactive Oxygen Species-Independent Negative Feedback Regulation of TLR9-Induced IL-12p70 in Murine Dendritic Cells. Cornelia Richter, Martina Herrero San Juan, Jutta Will, Ralf P. Brandes, Ulrich Kalinke, Shizuo Akira, Josef M. Pfeilschifter, Malin Hultqvist, Rikard Holmdahl and Heinfried H. Radeke. pharmazentrum frankfurt/Center for Drug Research, Development, and Safety and Institute of Cardiovascular Physiology, Clinic of J. W. Goethe University, Frankfurt, Germany; Division of Immunology, Paul-Ehrlich-Institute, Langen, Germany; Department of Host Defense, Research Institute of Microbial Diseases, Osaka University, Suita, Japan; and Section for Medical Inflammation Research, Karolinska Institutet Stockholm and Lund University, Lund, Sweden. The Journal of Immunology, 2009, 182, 4183 -4191.
101. HIV-1 Plasma Variants Encoding Truncated Reverse Transcriptase (RT) in a Patient With High RT-Specific CD8+ Memory T-Cell Response. Paolucci, Stefania; Foli, Andrea; Gulminetti, Roberto; Calarota, Sandra A.; Maserati, Renato; Baldanti, Fausto; Gerna, Giuseppe. Policlinico S. Matteo, Pavia, Italy. Current HIV Research, Volume 7, Number 3, May 2009 , pp. 302-310(9).
102. Adenosine and IFN- synergistically increase IFN-Gamma production of human NK cells. Florian Jeffe, Kerstin A. Stegmann, Felix Broelsch, Michael P. Manns, Markus Cornberg and Heiner Wedemeyer. Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany. Journal of Leukocyte Biology. 2009;85:452-461.
103. Prolonged Survival of Dendritic Cell–Vaccinated Melanoma Patients Correlates With Tumor-Specific Delayed Type IV Hypersensitivity Response and Reduction of Tumor Growth Factor β-Expressing T Cells. Mercedes N. López, Cristian Pereda, Gabriela Segal, Leonel Muñoz, Raquel Aguilera, Fermín E. González, Alejandro Escobar, Alexandra Ginesta, Diego Reyes, Rodrigo González, Ariadna Mendoza-Naranjo, Milton Larrondo, Alvaro Compán, Carlos Ferrada, Flavio Salazar-Onfray. From the Millennium Nucleus on Immunology and Immunotherapy, Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile; Research Support Office, Clinical Hospital of the University of Chile, Santiago; and the Regional Hospital of Concepción, Concepción, Chile. Journal of Clinical Oncology, Vol 27, No 6 (February 20), 2009: pp. 945-952.
104. HIV-1 Tat Addresses Dendritic Cells to Induce a Predominant Th1-Type Adaptive Immune Response That Appears Prevalent in the Asymptomatic Stage of Infection1. Emanuele Fanales-Belasio, Sonia Moretti, Valeria Fiorelli, Antonella Tripiciano, Maria R. Pavone Cossut, Arianna Scoglio, Barbara Collacchi, Filomena Nappi, Iole Macchia, Stefania Bellino, Vittorio Francavilla, Antonella Caputo, Giovanni Barillari, Mauro Magnani, Maria Elena Laguardia, Aurelio Cafaro, Fausto Titti, Paolo Monini, Fabrizio Ensoli and Barbara Ensoli2. National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; Department of Pathology and Microbiology, Istituti Fisioterapici Ospitalieri—S. Gallicano Hospital, IRCCS, Rome, Italy; Department of Histology, Microbiology and Medical Biotechnology, University of Padua, Padua, Italy; and Institute for Biological Chemistry "G. Fornaini", University of Urbino, Urbino, Italy. The Journal of Immunology, 2009, 182, 2888 -2897.
105. Systemic inflammatory response and downmodulation of peripheral CD25+Foxp3+ T-regulatory cells in patients undergoing radiofrequency thermal ablation for lung cancer. Anna Maria Fietta, Monica Morosini, Ileana Passadore, Alessandro Cascina, Paola Draghi, Roberto Dore, Sandro Rossi, Ernesto Pozzi and Federica Meloni. Department of Hematological, Pneumological, and Cardiovascular Sciences, Section of Pneumology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Interventional Ultrasonography, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Human Immunology Volume 70, Issue 7, July 2009, Pages 477-486.
106. Vaccination with human papillomavirus type 16-derived peptides using a tattoo device. Dana Pokorná, Ingrid Poláková, Martina Kindlová, Martina Du%u0161ková, Viera Ludvíková, Pavel Gabriel, Lud’a Kutinová, Martin Müller and Michal %u0160mahel. Institute of Hematology and Blood Transfusion, Department of Experimental Virology, Prague, Czech Republic. German Cancer Research Center, Research Group of Tumorvirus-Specific Vaccination Strategies, Heidelberg, Germany. Vaccine Volume 27, Issue 27, 2 June 2009, Pages 3519-3529.
107. Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes. Mark P. Ariaans, Peter M. van de Haar, Evert J. Hensen and Lonneke Vervelde. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Virology Volume 385, Issue 1, 1 March 2009, Pages 68-73.
108. Out of frame peptides from BCR/ABL alternative splicing are immunogenic in HLA A2.1 transgenic mice. C. Casnici, G. Volpe, D. Lattuada, K. Crotta, M. Kuka, C. Panuzzo, C. Mastrotto, G. Tonon, V. Fazio, G. Saglio. Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; Bio-Ker, Polaris Scientific Park, Piscinamanna-Pula (Cagliari), Italy; Interdisciplinary Center for Biomedical Research, Section of Molecular Medicine and Biotechnology, University Campus Bio-Medico, Rome, Italy; U.O. Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy. Cancer Letters, Volume 276, Issue 1, Pages 61-67, 8. April 2009.
109. Indoleamine 2,3-Dioxygenase in Lung Allograft Tolerance Corrected Proof. Federica Meloni, Serena Giuliano, Nadia Solari, Paola Draghi, Simona Miserere, Anna Maria Bardoni, Roberta Salvini, Francesco Bini, Anna Maria Fietta. University and IRCCS Policlinico S. Matteo, Pavia, Italy. The Journal of Heart and Lung Transplantation 2009.07.023.
110. Role of T cell competition in the induction of cytotoxic T lymphocyte activity during viral vector-based immunization regimens. Annechien J.A. Lambeck, Hans W. Nijman, Baukje Nynke Hoogeboom, Joke Regts, Arjan de Mare, Jan Wilschut and Toos Daemen. University Medical Center Groningen and University of Groningen, Groningen, The Netherlands. Vaccine 2010.04.033
111. Highly Differentiated, Resting Gn-Specific Memory CD8+ T Cells Persist Years after Infection by Andes Hantavirus. Tobias Manigold, Andrés Mori, Rebecca Graumann, Elena Llop, Valeska Simon, Marcela Ferrés, Francisca Valdivieso, Constanza Castillo, Brian Hjelle, and Pablo Vial. Institute of Science, Medical School, Clínica Alemana Universidad del Desarrollo, Santiago, Chile; Facultad de Medicina, Universidad de Chile, Santiago, Chile; Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Universidad de la Frontera, Temuco, Chile; University of New Mexico, Albuquerque, New Mexico, United States of America. PLoS Pathog. 2010 February; 6(2): e1000779.
112. Dynamics in cytokine responses during the development of occupational sensitization to rats.
E. J. M. Krop, M. A. van de Pol, R. Lutter, D. J. J. Heederik, R. C. Aalberse & J. S. van der Zee. Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam; Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam; Department of Immunopathology, Sanquin Blood Supply Foundation; Department of Pulmonology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. Allergy, January 28, 2010.
113. Results From a Phase I Clinical Study of the Novel Ii-Key/HER-2/neu(776-790) Hybrid Peptide Vaccine in Patients with Prostate Cancer Sonia A Perez, Kallinteris L Nikoletta, Bisias Stratos, Panagiotis K Tzonis, Katerina Georgakopoulou, Anastasios Thanos, Marigoula Varla-Leftherioti, Michael Papamichail, Eric von Hofe and Constantin N Baxevanis. Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, Biotech III, Antigen Express, Inc., Urology Department, Saint Savas Cancer Hospital, Immunobiology Department, Cancer Immunology and Immunotherapy Center, Athens, Greece. Clinical Cancer Research May 13, 2010.
114. Persistence of mucosal and systemic immune responses following sublingual immunization. Donatella R.M. Negri, Antonella Riccomi, Dora Pinto, Silvia Vendetti, Alessandra Rossi, Rosella Cicconi, Paolo Ruggiero, Giuseppe Del Giudice and Maria Teresa De Magistris. Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy; Research Center, Novartis Vaccines, Siena, Italy. Vaccine 2010.04.013.
115. T and B cells target identical regions of the non-collagenous domain 1 of type VII collagen in epidermolysis bullosa acquisita. Ralf Müller, Christiane Dahler, Christian Möbs, Elke Wenzel, Rüdiger Eming, Gerald Messer, Andrea Niedermeier and Michael Hertl. Department of Dermatology and Allergology, Philipps University Marburg, Germany and Department of Dermatology and Allergology, Ludwig-Maximilians University Munich, Germany. Clinical Immunology Volume 135, Issue 1, April 2010, Pages 99-107.
116. Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure. Evelien M. Bunnik, Marit J. van Gils, Marilie S. D. Lobbrecht, Linaida Pisas, Nening M. Nanlohy, Debbie van Baarle, Ad C. van Nuenen, Ann J. Hessell and Hanneke Schuitemaker. Department of Experimental Immunology, Sanquin Research; Landsteiner Laboratory and Center for Infection and Immunity Amsterdam (CINIMA); Academic Medical Center, University of Amsterdam, Amsterdam; University Medical Center Utrecht, Utrecht, The Netherlands; Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, USA. Journal of General Virology 91 (2010), 1354-1364.
117. Triggering DTH and CTL Activity by fd Filamentous Bacteriophages: Role of CD4+ T Cells in Memory Responses. Giovanna Del Pozzo, Dina Mascolo, Rossella Sartorius, Alessandra Citro, Pasquale Barba, Luciana D'Apice and Piergiuseppe De Berardinis. Institute of Genetics and Biophysics “Adriano Buzzati Traverso” and Institute of Protein Biochemistry, CNR, Naples, Italy. Journal of Biomedicine and Biotechnology Volume 2010.
118. Birch Pollen Immunotherapy Leads to Differential Induction of Regulatory T Cells and Delayed Helper T Cell Immune Deviation. Christian Möbs, Caroline Slotosch, Harald Löffler, Thilo Jakob, Michael Hertl and Wolfgang Pfützner. Department of Dermatology and Allergology, Philipps University Marburg, Marburg; Department of Dermatology, SLK-Clinics Heilbronn, Heilbronn and Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany. The Journal of Immunology, 2010, 184, 2194 -2203.
119. Determining the Activity of Mucosal Adjuvants. Barbara C. Baudner and Giuseppe Del Giudice. Novartis Vaccines and Diagnostics, Siena, Italy. Methods in Molecular Biology Volume 626 2010
120. Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART. Marchetti, Giulia; Gazzola, Lidia; Trabattoni, Daria; Bai, Francesca; Ancona, Giuseppe; Ferraris, Laurenzia; Meroni, Luca; Galli, Massimo; Clerici, Mario; Gori, Andrea; d'Arminio Monforte, Antonella. University of Milano, Italy. AIDS 19 June 2010 - Volume 24.
121. Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor. Ilaria Marigo, Erika Bosio, Samantha Solito, Circe Mesa, Audry Fernandez, Luigi Dolcetti, Stefano Ugel, Nada Sonda, Silvio Bicciato, Erika Falisi, Fiorella Calabrese, Giuseppe Basso, Paola Zanovello, Emanuele Cozzi, Susanna Mandruzzato and Vincenzo Bronte. Department of Oncology and Surgical Sciences, University of Padua, 35128 Padua, Italy; Department of Medical Diagnostic Sciences and Special Therapies, University of Padua, 35128 Padua, Italy; Center of Molecular Immunology, 16040 Havana, Cuba; Venetian Institute for Molecular Medicine, 35129 Padua, Italy; Center for Genome Research, Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy; Department of Pediatrics, University of Padua, 35100 Padua, Italy; Istituto Oncologico Veneto (IOV), IRCCS, 35128 Padua, Italy; Direzione Sanitaria, Padua General Hospital, 35128 Padua, Italy. Journal of Immunology 2010.05.010.
122. Evaluation of Cytomegalovirus (CMV)%u2010Specific T Cell Immune Reconstitution Revealed that Baseline Antiviral Immunity, Prophylaxis, or Preemptive Therapy but not Antithymocyte Globulin Treatment Contribute to CMV%u2010Specific T Cell Reconstitution in Kidney Transplants Recipients. Davide Abate, Alda Saldan, Marta Fiscon, Simona Cofano, Adriana Paciolla, Lucrezia Furian, Burcin Ekser, Maria Angela Biasolo, Riccardo Cusinato, Carlo Mengoli, Luciana Bonfante, Barbara Rossi, Paolo Rigotti, Dino Sgarabotto, Luisa Barzon and Giorgio Palù. Departments of Histology, Microbiology, and Medical Biotechnology, General Surgery and Solid Organ Transplantation, Surgical and Medical Sciences–Nephrology I, Hemodialysis and Nephrology II, Transplant Infection Diseases Unit, Padua General Hospital, University of Padua School of Medicine via Gabelli, Padova, Italy. The Journal of Infectious Diseases 2010;202:000–000.
123. Selectivity of Oncolytic Viral Replication Prevents Antiviral Immune Response and Toxicity, but Does Not Improve Antitumoral Immunity. Engin Gürlevik, Norman Woller, Nina Strüver, Peter Schache, Arnold Kloos, Michael P Manns, Lars Zender, Florian Kühnel and Stefan Kubicka, Hannover Medical School, Germany. Molecular Therapy August 10th 2010.
124. Maintenance immunosuppressive therapy with everolimus preserves humoral immune responses. Geertrude H Struijk, Robert C Minnee, Sven D Koch, Aeilko H Zwinderman, Karlijn A M I van Donselaar-van der Pant, Mirza M Idu, Ineke J M ten Berge and Frederike J Bemelman. Academic Medical Center Amsterdam, The Netherlands. Kidney International August 11th 2010.
125. Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics. Van de Pol MA, Lutter R, Smids BS, Weersink EJ, van der Zee JS. Department of Pulmonology, Academic Medical Center Amsterdam, the Netherlands. Allergy Aug 17. 2010.
126. Th1 immune response to Plasmodium falciparum circumsporozoite protein is boosted by adenovirus vectors 35 and 26 with homologous insert. Katarina Radosevic, Ariane Rodriguez, Angelique A.C. Lemckert, Marjolein van der Meer, Gert Gillissen, Carolien Warnar, Rie von Eyben, Maria Grazia Pau, and Jaap Goudsmit. Crucell Holland B. V., Leiden, The Netherlands; and Center of Poverty-related Communicable Diseases, Academic Medical Center, Amsterdam, The Netherlands. Clin. Vaccine Immunol. doi:10.1128/CVI.00311-10.
127. No difference in Gag and Env immune response profiles between vaccinated and non vaccinated rhesus macaques that control immunodeficiency virus replication. Ivonne Nieuwenhuis, Niels Beenhakker, Willy Bogers, Nel Otting, Ronald Bontrop, Patrice Dubois, Petra Mooij1, Jonathan Luke Heeney and Gerrit Koopman. Biomedical Primate Research Centre, Rijswijk, the Netherlands, Immuno Vacc Consulting, Brussels, Belgium and University of Cambridge, UK. Jorunal Gen Virol (2010), DOI 10.1099/vir.0.022772-0.
128. Influenza antigen-sparing by immune stimulation with Gram-positive enhancer matrix (GEM) particles. V. Salujaa, M.R. Vissera, W. ter Veerb, M.L. van Roosmalenc, K. Leenhoutsc, W.L.J. Hinrichsa, A. Huckriedeb and H.W. Frijlinka. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands, Department of Medical Microbiology, Molecular Virology Section, University Medical Center and University of Groningen, The Netherlands and c Mucosis BV, Meditech Center, Groningen, The Netherlands. j.vaccine.2010.09.066.
129. IFN-α boosts epitope cross-presentation by dendritic cells via modulation of proteasome activity. Laura Lattanzia, Carmela Rozeraa, Diego Marescottib, Giuseppina D’Agostinoa, Laura Santodonatoa, Silvia Cellinib, Filippo Belardellia, Riccardo Gaviolib and Maria Ferrantinia. Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy and Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy. doi:10.1016/j.imbio.2010.10.003.
130. Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime–boost immunisation in non-human primates.Stefania Caponea, Arturo Reyes-Sandovalb, Mariarosaria Naddeoa, Loredana Siania, Virginia Ammendolaa, Christine S. Rollierb, Alfredo Nicosiaa, Stefano Collocaa, Riccardo Cortesea, Antonella Folgoria, and Adrian V.S. Hillb. Okairos, Rome, Italy and The Jenner Institute, University of Oxford, UK. doi:10.1016/j.vaccine.2010.10.041
131. Evaluation and characterization of the capability of dendritic cells generated by exposure of human peripheral blood monocytes to GM-CSF and IFN-alpha of inducing CD8 T cell priming and TH1 polarization. Facoltà di Medicina e Chirurgia, Università degli Studi di Roma “Tor Vergata”, Dottorato di Ricerca in “Microbiologia Medica ed Immunologia”Roma. Candidato Dott. Simona Donati, Coordinatore Prof. Carlo F. Perno. August 2008.
132. Zelluläre Mechanismen der Toleranzinduktion unter spezifischer Immuntherapie mit inhalativen Allergenen. Christian Möbs, Inaugural-Dissertation zur Erlangung des Doktorgrades der Humanbiologie. Klinik für Dermatologie und Allergologie der Philipps-Universität Marburg im Juni 2010. Referent PD Dr. Wolfgang Pfützner.
133. Safety and Immunogenicity of a Recombinant Plasmodium falciparum AMA1 Malaria Vaccine Adjuvanted with Alhydrogel™, Montanide ISA 720 or AS02. Roestenberg, Meta; Remarque, Ed; de Jonge, Erik; Hermsen, Rob; Blythman, Hildur; Leroy, Odile; Imoukhuede, Egeruan; Jepsen, Soren; Ofori-Anyinam, Opokua; Faber, Bart; Kocken, Clemens H. M.; Arnold, Miranda; Walraven, Vanessa; Teelen, Karina; Roeffen, Will; de Mast, Quirijn; Ballou, W. Ripley; Cohen, Joe; Dubois, Marie Claude; Ascarateil, Stéphane; van der Ven, Andre; Thomas, Alan; Sauerwein, Robert; Editor: Beeson, James G.. Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Biomedical Primate Research Centre, Rijswijk; The Netherlands; European Malaria Vaccine Initiative, Copenhagen, Denmark; GlaxoSmithKline Biologicals, Rixensart, Belgium; SEPPIC, Paris, France; Walter and Eliza Hall Institute of Medical Research, Australia. Plosone 2008,Jan,01.
134. Association of high anti-donor alloreactivity and low frequency of FoxP3-expressing cells prior to kidney transplantation with acute graft rejection. Florian W.R. Vondran, Kai Timrott, Janice Tross1, Sonja Kollrich1, Wilfried Gwinner, Frank Lehner1, Juergen Klempnauer, Thomas Becker and Reinhard Schwinzer. Medical School Hannover, Germany. Transplantation 2010 DOI: 10.1111/j.1399-0012.2010.01354.
135. Intranasal delivery of influenza subunit vaccine formulated with GEM particles as an adjuvant. Vinay Saluja, Jean P. Amorij, Maarten L. van Roosmalen, Kees Leenhouts, Anke Huckriede, Wouter L.J. Hinrichs and Henderik W. Frijlink.
Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands; Mucosis BV, Meditech Center, Groningen, The Netherlands; Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, The Netherlands; Research and Development Unit, The Netherlands Vaccine Institute, Bilthoven, The Netherlands. AAP S Journal 2010; 12 (2): 109-16
136. Enhanced B Cell Differentiation and Reduced Proliferative Capacity in Chronic Hepatitis C and Chronic Hepatitis B Virus Infections. Barbara Oliviero, Antonella Cerino, Stefania Varchetta, Enrica Paudice, Somnath Pai, Serena Ludovisi, Marco Zaramella, Giuseppe Michelone, Paolo Pugnale, Francesco Negro, Vincenzo Barnaba and Mario U. Mondelli. Molecular Infectious Disease Unit, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Italy; Division of Infectious Diseases, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Italy; Viropathology Unit, University Hospitals, Geneva, Switzerland;Department of Internal Medicine, Fondazione Andrea Cesalpino and Istituto Pasteur-Cenci Bolognetti, University of Rome La Sapienza, Rome, Italy. Journal of Hepatology 2010.10.016.
137. Increased frequency of immunoglobulin (Ig)A-secreting cells following Toll-like receptor (TLR)-9 engagement in patients with Kawasaki disease. L. Giordani, M. G. Quaranta, A. Marchesi, E. Straface, D. Pietraforte, A. Villani, W. Malorni, D. Del Principe, M. Viora. Departments of Therapeutic Research and Medicine Evaluation, Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome Italy; Department of Pediatrics, Bambino Gesù Hospital, Rome, Italy; Istituto San Raffaele Sulmona, L'Aquila, Italy. The Journal of Translational Immunology DOI: 10.1111/j.1365-2249.2010.04297.x.
138. IMMUNOGENIC COMPOSITIONS CAPABLE OF ACTIVATING T-CELLS. Gebbink, Martijn Frans Ben Gerard (Eemnes, NL); Bouma, Barend (Houten, NL); Steverink, Paulus Johannes Gerardus Maria (Huizen, NL); Renes, Johan (Amersfoort, NL). United States Patent Application 20110008376.
139. Preclinical evaluation of the saponin derivative GPI-0100 as an immunostimulating and dose-sparing adjuvant for pandemic influenza vaccines.Heng Liua, Laura Bungenera, Wouter ter Veera, Beth-Ann Collerb, Jan Wilschuta and Anke Huckriedea, Department of Medical Microbiology, Molecular Virology Section, University Medical Center and University of Groningen, The Netherlands and Hawaii Biotech Inc., Aiea, USA. j.vaccine.2011.01.012.
140. Immunocompetent cell functions in Ph+ acute lymphoblastic leukemia patients on prolonged Imatinib maintenance treatment. Roberta Maggio, Nadia Peragine, Maria Stefania De Propris, Antonella Vitale, Loredana Elia, Elisabetta Calabrese, Irene Della Starza, Stefania Intoppa, Maria Laura Milani, Anna Guarini and Robin Foà. Department of Cellular Biotechnlologies and Hematology, "Sapienza" University of Roma, Italy. Cancer Immunology, Immunotherapy DOI: 10.1007/s00262-010-0966-2
141. Proteasome inhibitors induce the presentation of an Epstein–Barr virus nuclear antigen 1-derived cytotoxic T lymphocyte epitope in Burkitt’s lymphoma cells. Federica Destro, Fabio Sforza, Mariaconcetta Sicurella, Diego Marescotti, Eleonora Gallerani, Anna Baldisserotto, Mauro Marastoni and Riccardo Gavioli. Department of Biochemistry and Molecular Biology, Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy. Immunology DOI: 10.1111/j.1365-2567.2011.03416.x
142. A combination HIV vaccine based on Tat and Env proteins was immunogenic and protected macaques from mucosal SHIV challenge in a pilot study. Flavia Ferrantelli, Maria Teresa Maggiorella, Ilaria Schiavoni, Leonardo Sernicola, Erika Olivieri, Stefania Farcomeni, Maria Rosaria Pavone-Cossut, Sonia Moretti, Roberto Belli, Barbara Collacchi, Indresh K. Srivastava, Fausto Titti, Aurelio Cafaro, Susan W. Barnett and Barbara Ensoli. National AIDS Center, Istituto Superiore di Sanità, Rome, Italy and Novartis Vaccines and Diagnostics, Inc., Cambridge, MA, USA. Vaccine doi:10.1016/j.vaccine.2011.02.006
143. Strong CD8+ T cell antigenicity and immunogenicity of large foreign proteins incorporated in HIV-1 VLPs able to induce a Nef-dependent activation/maturation of dendritic cells. A. Sistigua, L. Braccia, M. Valentinia, E. Proiettia, R. Bonab, D.R.M. Negric, A.R. Ciccaglionec, E. Tritarellic, R. Nisinic, M. Equestreb, A. Costantinoc, C. Marcantonioc, S.M. Santinia, C. Lapentaa, S. Donatia, P. Tataseod, M. Micelie, A. Carab and M. Federicof. Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy; Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy; Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy; ASL Avezzano-Sulmona, Transfusional Medicine and Molecular Biology Laboratory, Sulmona, Italy; Azienda Ospedaleria S. Camillo-Forlanini, Rome, Italy; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy. doi:10.1016/j.vaccine.2011.02.059
144. Embryonic Stem Cells, Derived Either after In Vitro Fertilization or Nuclear Transfer, Prolong Survival of Semiallogeneic Heart Transplants. Barbara Imberti, Federica Casiraghi, Daniela Cugini, Nadia Azzollini, Paola Cassis, Marta Todeschini, Samantha Solini, Vittorio Sebastiano, Maurizio Zuccotti, Silvia Garagna, Carlo Alberto Redi, Marina Noris, Marina Morigi and Giuseppe Remuzzi. Department of Molecular Medicine, “Mario Negri” Institute for Pharmacological Research, Bergamo, Italy; Transplant Research Center Chiara Cucchi De Alessandri and Gilberto Crespi, “Mario Negri” Institute for Pharmacological Research, Ranica, Bergamo, Italy; Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia Animale, Centro di Eccellenza in Biologia Applicata, Università degli Studi di Pavia, Pavia , Italy; Centro di Ricerca Interdipartimentale di Ingegneria Tissutale, Università degli Studi di Pavia, Pavia, Italy; Sezione di Istologia e Embriologia, Dipartimento di Medicina Sperimentale, Università degli Studi di Parma, Parma, Italy; Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; and Unità di Nefrologia e Dialisi, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Bergamo, Italy. doi: 10.4049/jimmunol.1000654
145. Methods and kits for inducing a ctl response using a prime boot regimen. United States Patent Application 20110110974. Publication date 05/12/2011. Depla, Erik (Destelbergen, BE) and Van Der, AA Annegret (Berendrecht, BE).
146. Cetuximab +/%u2212 chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. P Correale1, C Botta, MG Cusi, MT Del Vecchio, MM De Santi, G Gori Savellini, E Bestoso, S Apollinari, S Mannucci, M Marra, A Abruzzese, A Aquino, M Turriziani, L Bonmassar, M Caraglia and P Tagliaferri. Siena University School of Medicine, Siena, Italy; Second Naples University, Naples, Italy; University “Tor Vergata”, Rome, Italy; Istituto Dermopatico dell'Immacolata-IRCCS, Rome, Italy and “Magna Graecia” University School of Medicine, Catanzaro, Italy. International Journal of Cancer, DOI: 10.1002/ijc.26181.
147. Settings for recombinant adenoviral-based vaccines. United States Patent Application 20110130301. Publication Date 06/02/2011. Havenga, Menzo J. E. (Alphen a/d Rijn, NL) and Kostense, Stefan (Den Haag, NL).
148. Erythropoietin enhances immunostimulatory properties of immature dendritic cells. F. Rocchetta, S. Solini, M. Mister, C. Mele, P. Cassis, M. Noris, G. Remuzzi and S. Aiello. Transplant Research Center ‘Chiara Cucchi de Alessandri e Gilberto Crespi’, Mario Negri Institute for Pharmacological Research; Department of Immunology and Organ Transplantation, Ospedali Riuniti – Mario Negri Institute for Pharmacological Research, Bergamo, Italy. Clinical & Experimental Immunology, DOI: 10.1111/j.1365-2249.2011.04417.x.
149. Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. Swantje I. Hammerschmidt, Michaela Friedrichsen, Jasmin Boelter, Marcin Lyszkiewicz, Elisabeth Kremmer, Oliver Pabst and Reinhold Förster. Institute of Immunology Hannover Medical School, Hannover and Institute of Molecular Immunology, Helmholtz Zentrum München, Munich, Germany. J Clin Invest. doi:10.1172/JCI44262.
150. A novel guinea pig model of Chlamydia trachomatis genital tract infection. Marien I. de Jongea, Sander A.S. Keizera, Hicham M. el Moussaouia, Lieke van Dorstena, Rima Azzawia, Hanneke I. van Zuilekoma, Patricia P.W. Petersa, Fred J.H. van Opzeelandc, Laura van Dijka, Rob Nieuwlandb, Henriëtte W.M. Roosenboom-Theunissenb, Mieke P. Vrijenhoekb, Isolde Debyserd, Pierre J.M. Verweije, Wilbert G.F. van Duijnhovene, Johannes F. van den Boscha and Piet J.M. Nuijtena. Nobilon MSD, Department of Bacteriological R&D, Boxmeer, The Netherlands; Department of Pathological R&D, Intervet/Schering-Plough Animal Health, Boxmeer, The Netherlands; Animal Service Department, Intervet/Schering-Plough Animal Health, Boxmeer, The Netherlands; BVBA de Landloper, Consultancy in Veterinary Pathology, Bever, Belgium; MSD, Biostatistics and Research Decision Sciences, Oss, The Netherlands. doi:10.1016/j.vaccine.2011.06.037.
151. Functional Gap Junctions Accumulate at the Immunological Synapse and Contribute to T Cell Activation. Ariadna Mendoza-Naranjo, Gerben Bouma, Cristián Pereda, Marcos Ramírez, Kevin F. Webb, Andrés Tittarelli, Mercedes N. López, Alexis M. Kalergis, Adrian J. Thrasher, David L. Becker and Flavio Salazar-Onfray. Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, University of Chile, Santiago, Chile; University College London Cancer Institute, London, United Kingdom; Molecular Immunology Unit, University College London Institute of Child Health, London, United Kingdom; Department of Cell and Developmental Biology, University College London, London, United Kingdom and Department of Molecular Genetics and Microbiology, Millennium Institute on Immunology and Immunotherapy, Pontifical Catholic University of Chile, Santiago, Chile. The Journal of Immunology, Accepted July 14, 2011.
152. HER2-based recombinant immunogen to target DCs through FcγRs for cancer immunotherapy. Ilaria Grazia Zizzari, Filippo Veglia, Federica Taurino, Hassan Rahimi, Elena Quaglino, Francesca Belleudi, Federica Riccardo, Morena Antonilli, Chiara Napoletano und Filippo Bellati, Pierluigi Benedetti-Panici, Maria Rosaria Torrisi, Luigi Frati, Marianna Nuti, 6 and Aurelia Rughetti. Department of Experimental Medicine, “Sapienza” University of Rome, , Italy; Molecular Biotechnology Center, University of Turin, Turin, Italy; Department of Clinical and Molecular Medicine, “Sapienza” University of Rome, Rome, Italy; Department of Obstetrics and Gynecology, “Sapienza” University of Rome, Rome, Italy; Department of Molecular Medicine, “Sapienza” University of Rome, Rome, Italy and Neuromed Institute, Pozzilli, Italy. Journal of Molecular Medicine. DOI: 10.1007/s00109-011-0794-7.
153. Influenza vaccination in primary and secondary immunodeficiencies. Sander van Assen, University of Groningen, The Netherlands. Doctoral disertation from September 2011.
154. Gene Vector for inducing Transgebe-Specific Immune Tolerance. Annoni, Andrea; Cantore, Alessio; Naldini, Luigi and Roncarolo, Maria Grazia. Fondazione Centro San Raffaele Del Monte Tabor, Milan, Italy and Fondazione Telethon, Rome, Italy. United States Patent Application 20110218234 from 09/08/2011.
155. Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice. Angelos D. Gritzapis, Ioannis F. Voutsas und Constantin N. Baxevanis. Cancer Immunology and Immunotherapy Center, St. Savas Cancer Hospital, Athens, Greece. Cancer Immunology, Immunotherapy DOI: 10.1007/s00262-011-1113-4.
156. Zelluläre Mechanismen der Toleranzinduktion unter spezifischer sublingualer Immuntherapie mit Birkenpollenallergenen. Inaugural-Dissertation zur Erlangung des Doktorgrades der gesamten Humanmedizin dem Fachbereich Medizin der Philipps-Universität Marburg vorgelegt von Karolin Ruge aus Weimar, Marburg 2011.
157. Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics. M. A. van de Pol, R. Lutter, R. van Ree and J. S. van der Zee. Otorhinolaryngology, Academic Medical Center, University of Amsterdam and Department of Pulmonology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. European Journal of Allergy and Clinical Immunology, DOI: 10.1111/j.1398-9995.2011.02722.x.
158. OVERLAPPING PEPTIDES FROM VARIABLE ANTIGENS, T CELL POPULATIONS AND USES THEREOF. Malnati, Mauro Severo (Milano, IT); Lusso, Paolo (Milano, IT); Poli, Guido (Milano, IT); Cosma, Antonio (Munich, DE) and Erfle, Volker (Munich, DE). United States Patent Application 20110236409 from 09/29/2011.
159. Controlling herpesviruses after allogeneic stem cell transplantation: Predictive features of T-cell immunity. Floortje Liselotte Dessing-Pietersma. University of Utrecht, The Netherlands. Doctoral disertation from September 2011.
160. A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses. Mauro S. Malnatia, Silvia Heltaia, Antonio Cosma, Peter Reitmeir, Simone Allgayer, Richard H. Glashoff, Walter Liebrich, Eftyhia Vardas, Nesrina Imami, Samantha Westrop, Silvia Nozza, Giuseppe Tambussi, Stefano Buttò, Emanuele Fanales-Belasio, Barbara Ensoli, Fabrizio Ensoli, Antonella Tripiciano, Claudio Fortis, Paolo Lusso, Guido Poli, Volker Erfle and Harvey Holmes. San Raffaele Scientific Institute, Milan, Italy; University Vita e Salute, Milan, Italy; Clinical cooperation group “Immune monitoring”, Helmholtz Zentrum, München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Virology, Helmholtz Zentrum, München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Health Economics and Health Care Management, Helmholtz Zentrum, München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Virology, Technical University, Munich, Germany; Division of Medical Virology, University of Stellenbosch, South Africa; University of Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa; Imperial College-London, United Kingdom; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; S.Gallicano Hospital, IFO, Rome, Italy; Centre for AIDS Reagents (CFAR), Health Protective Agency, Potters Bar, Hertfordshire, United Kingdom. Journal of Immunological Methods, doi:10.1016/j.jim.2011.09.005.
161. PLGA, PLGA-TMC and TMC-TPP Nanoparticles Differentially Modulate the Outcome of Nasal Vaccination by Inducing Tolerance or Enhancing Humoral Immunity. Chantal Keijzer, Bram Slütter, Ruurd van der Zee, Wim Jiskoot, Willem van Eden and Femke Broere. Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands, Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden, The Netherlands. PLoS ONE 6(11): e26684. doi:10.1371/journal.pone.0026684.
162. A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies.Elena Muraro, Debora Martorelli, Elisa Turchet, Gianmaria Miolo, Simona Scalone, Elisa Comaro, Renato Talamini, Katy Mastorci, Davide Lombardi, Tiziana Perin, Antonino Carbone, Andrea Veronesi, Diana Crivellari and Riccardo Dolcetti.
Breast Cancer Research 2011, 13:R117 doi:10.1186/bcr3060
163. Settings for recombinant adenoviral-based vaccines. United States Patent Application 20110311580. Inventors: Vogels, Ronald, (Linschoten, NL); Pau, Maria Grazia (Leiden, NL); Holterman, Lennart (Zoetemeer, NL); Kostense, Stefan (Den Haag, NL); Havenga, Menzo Jans Emco (Alphen aan den Rijn, NL) and Sprangers, Mieke Caroline (Essen, DE). Assignee: Crucell Holland B.V.. Publication Date: 12/22/2011.
164. Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Chiara Napoletano, Ilaria G. Zizzari, Aurelia Rughetti, Hassan Rahimi, Tatsuro Irimura, Henrik Clausen, Hans H. Wandall, Francesca Belleudi, Filippo Bellati, Luca Pierelli, Luigi Frati and Marianna Nuti. Department of Experimental Medicine, “Sapienza” University, Rome, Italy; Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan; Center for Glycomics, Department of Cellular and Molecular Medicine and School of Dentistry, University of Copenhagen, Denmark; Department of Molecular Medicine “Sapienza” University, Rome, Italy and Department of Obstetrics and Gynecology, “Sapienza” University, Rome, Italy. European Journal of Immunology DOI: 10.1002/eji.201142086.
165. Heat-shock protein 70 from plant biofactories of recombinant antigens activate multiepitope-targeted immune responses. Giampaolo Buriani, Camillo Mancini, Eugenio Benvenuto and Selene Baschieri. Laboratorio Biotecnologie Unità Tecnica BIORAD, ENEA C.R. Casaccia, Roma, Italy. Plant Biotechnology Journal DOI: 10.1111/j.1467-7652.2011.00673.x.
166. A designed Tat immunogen generates enhanced anti-Tat C-terminal antibodies. Wenting Liao, Qiuli Chen, Jie Cao, Guangguo Tan, Zhenyu Zhu, Huaqun Zhang, Yifeng Chai, Wei Pan. Department of Microbiology, Second Military Medical University, Shanghai, China and School of Pharmacy, Second Military Medical University, Sha-nghai, China. j.vaccine.2012.01.055.
167. Bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice. Krystelle Nganou-Makamdop, Maarten L van Roosmalen, Sandrine AL Audouy, Geert-Jan van Gemert, Kees Leenhouts, Cornelus C Hermsen and Robert W Sauerwein. Department of Medical Microbiology, Radboud University Nijmegen, The Netherlands; Mucosis BV, Groningen, The Netherlands; BiOMaDe Technology Foundation, Groningen, The Netherlands. Malaria Journal 2012, doi:10.1186/1475-2875-11-50.
168. Identification of Novel Avian Influenza Virus Derived CD8+ T-Cell Epitopes. Sylvia S. N. Reemers, Daphne A. van Haarlem, Alice J. A. M. Sijts, Lonneke Vervelde, Christine A. Jansen; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. PLoS ONE 7(2): 31953. doi:10.1371/journal.pone.0031953.
169. Human Cytomegalovirus (CMV) specific T-cell immune reconstitution in pre-emptive treated heart transplant recipients identifies critical subjects at risk of infection. Davide Abate, Marta Fiscon, Alda Saldan, Simona Cofano, Carlo Mengoli, Dino Sgarabotto, Chiara d'Agostino, Luisa Barzon, Riccardo Cusinato, Giuseppe Toscano, Giuseppe Feltrin, Antonio Gambino, Gino Gerosa and Giorgio Palù. Department of Molecular Medicine, Department of Cardiological, Chest and Vascular Sciences, Transplant infectious disease division, Padua General Hospital - University of Padua School of Medicine, Padova, Italy. Journal of Clinical Microbiology, doi: 10.1128/JCM.06406-11.
170. Isolation and culture of pig tonsil lymphocytes. E. Razzuoli, E. Faggionato, S. Dotti, R. Villa, T. Lombardo, L. Boizza, M. Ferrari, M. Amadori. Laboratory of Cellular Immunology, IZSLER, Brescia, Italy and Laboratory of Chemical Residues in Food of Plant Origin, IZSLER, Brescia, Italy. Journal of Veterinary Immunology and Immunopathology 2012.04.022.
171. Single DermaVir Immunization: Dose-Dependent Expansion of Precursor/Memory T Cells against All HIV Antigens in HIV-1 Infected Individuals. Julianna Lisziewicz, Nyasha Bakare, Sandra A. Calarota, Dénes Bánhegyi, János Szlávik, Eszter Újhelyi, Enik%u0151 R. T%u0151ke, Levente Molnár, Zsolt Lisziewicz, Brigitte Autran and Franco Lori. Genetic Immunity, Budapest, Hungary and Genetic Immunity Inc, Mclean, Virginia, United States of America, The Research Institute for Genetic and Human Therapy, Cambridge, Massachusetts, United States of America, Szent László Hospital, Budapest, Hungary, Laboratoire d’ Immunologie Cellulaire, Centre Hospitalier Universitaire Pitié-Salpétrière, Paris, France. PLoS ONE 7(5): e35416. doi:10.1371/journal.pone.0035416.
172. Integrase-defective lentiviral vectors encoding cytokines induce differentiation of human dendritic cells and stimulate multivalent immune responses in vitro and in vivo. Anusara Daenthanasanmak, Gustavo Salguero, Sylvia Borchers, Constanca Figueiredo, Roland Jacobs, Bala Sai Sundarasetty, Andreas Schneider, Axel Schambach, Britta Eiz-Vesper, Rainer Blasczyk, Eva M. Weissinger, Arnold Ganser, Renata Stripeckea. Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany; Transfusion Medicine, Hannover Medical School, Hannover, Germany; Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany and Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany. J.Vaccine.2012.05.063.
173. Easy and Efficient Protocols for Working with Recombinant Vaccinia Virus MVA. Melanie Kremer, Asisa Volz, Joost H. C. M. Kreijtz, Robert Fux, Michael H. Lehmann and Gerd Sutter. Institute for Infectious Diseases and Zoonoses, University of Munich LMU, Munich, Germany and Department of Virology, Erasmus MC, Rotterdam, The Netherlands. Methods in Molecular Biology, 2012, Volume 890, 59-92.
174. Successful therapeutic vaccination with integrase defective lentiviral vector expressing non-oncogenic human papilloma virus E7 protein. Felicia Grasso,Donatella RM Negri, Stefania Mochi, Alessandra Rossi, Armando Cesolini, Andrea Giovannelli, Maria Vincenza Chiantore, Pasqualina Leone, Colomba Giorgi and Andrea Cara. International Journal of Cancer, DOI: 10.1002/ijc.27676.
175. United States Patent 8227243: Settings for recombinant adenoviral-based vaccines. Described are new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, also described are new assays to determine the best regimen for applying the most suitable recombinant viral vector in a vaccination or gene therapy setting. Inventors: Vogels, Ronald (Linschoten, NL); Pau, Maria Grazia (Leiden, NL); Holterman, Lennart (Zoetemeer, NL); Kostense, Stefan (The Hague, NL); Havenga, Menzo Jans Emco (Alphen aan den Rijn, NL); Sprangers, Mieke Caroline (Essen, DE). Assignee: Crucell Holland B.V. (Leiden, NL). Publication Date: 07/24/2012.
176. United States Patent Application 20120219586: ADJUVANTED VACCINE FORMULATIONS. The invention relates to adjuvanted vaccine formulations, in particular influenza vaccines for intranasal delivery. Provided is an adjuvanted influenza vaccine formulation, comprising (i) peptidoglycan microparticles obtained from a Gram-positive bacterium and (ii) at least one influenza virus antigen or antigenic preparation thereof, which antigen or antigenic preparation is not fused or otherwise covalently attached to a proteinaceous peptidoglycan binding moiety. Inventors: Schouten, Govert Johan (Leiderdorp, NL) and Leenhouts, Cornelis Johannes (Haren, NL). Publication Date: 08/30/2012.
177. Antigen presentation under the influence of ‘immune evasion’ proteins and its modulation by interferon-gamma: Implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells. Annette Fink, Niels A. W. Lemmermann, Dorothea Gillert-Marien, Doris Thomas, Kirsten Freitag, Verena Böhm, Vanessa Wilhelmi, Kurt Reifenberg, Matthias J. Reddehase und Rafaela Holtappels. Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Germany and Animal Laboratory Services, German Cancer Research Center, Heidelberg, Germany. Medical Microbiology and Immunology 2012, DOI: 10.1007/s00430-012-0256-z.
178. Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies. Christian Möbs, Henrik Ipsen, Lea Mayer, Caroline Slotosch, Arnd Petersen, Peter A. Würtzen, Michael Hertl and Wolfgang Pfützner. Department of Dermatology and Allergology, Philipps University Marburg, Germany, Vaccine Research and Discovery, ALK-Abelló, Hørsholm, Denmark and Clinical and Molecular Allergology Research Center Borstel, Germany. The Journal of Allergy and Clinical Immunology, doi: 10.1016/j.jaci.2012.07.056.
179. VS411 Reduced Immune Activation and HIV-1 RNA Levels in 28 Days: Randomized Proof-of-Concept Study for AntiViral-HyperActivation Limiting Therapeutics. Franco Lori, Davide De Forni, Elly Katabira, Denis Baev, Renato Maserati, Sandra A. Calarota, Pedro Cahn, Marco Testori, Aza Rakhmanova and Michael R. Stevens. ViroStatics srl, Alghero, Italy; Makerere Medical School, Kampala, Uganda; Infectious Diseases Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Fundación Huesped, Buenos Aires, Argentina; Department of Infectious Diseases, St. Petersburg Health Department, St. Petersburg, Russia and ViroStatics srl, Princeton, New Jersey, United States of America. PLoS ONE 7(10): e47485. doi:10.1371/journal.pone.0047485.
180. A strategy of antigen incorporation into exosomes: Comparing cross-presentation levels of antigens delivered by engineered exosomes and by lentiviral virus-like particles. Laura Lattanzi and Maurizio Federico. Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy and National AIDS Center, Istituto Superiore di Sanità, Rome, Italy. j.vaccine.2012.10.010.
181. Human T cells directed to seasonal influenza A virus cross-react with A(H1N1)pdm09 and swine origin triple reassortant H3N2 influenza viruses. Marine L. B. Hillaire, Stella E. Vogelzang-van Trierum, Joost H. M. C. Kreijtz, Gerrie de Mutsert, Ron A. M. Fouchier, Albert D. M. E. Osterhaus and Guus F. Rimmelzwaan. Erasmus MC Rotterdam, The Netherlands. Journal of General Virology November 2012 vir.0.048652-0.
182. Enhancement of the Immunogenicity and Protective Efficacy of a Mucosal Influenza Subunit Vaccine by the Saponin Adjuvant GPI-0100. Heng Liu, Harshad P. Patil, Jacqueline de Vries-Idema, Jan Wilschut and Anke Huckriede. Department of Medical Microbiology, Molecular Virology Section, University of Groningen, University Medical Center Groningen, The Netherlands. PLoS ONE 7(12): e52135. doi:10.1371/journal.pone.0052135.
183. Detection of Epstein-Barr virus-specific memory CD4+ T cells using a peptide-based cultured enzyme-linked immunospot assay. Sandra A. Calarota, Antonella Chiesa, Paola Zelini, Giuditta Comolli, Lorenzo Minoli and Fausto Baldanti. Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. DOI: 10.1111/imm.12106.
184. Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response. Chiara Camisaschi, Paola Filipazzi, Marcella Tazzari, Chiara Casati, Valeria Beretta, Lorenzo Pilla, Roberto Patuzzo, Andrea Maurichi, Agata Cova, Michele Maio, Vanna Chiarion-Sileni, Gabrina Tragni, Mario Santinami, Barbara Vergani, Antonello Villa. Emilio Berti, Ludmila Umansky, Philipp Beckhove, Viktor Umansky, Giorgio Parmiani, Licia Rivoltini and Chiara Castelli. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; University Hospital of Siena, Italy; Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy; Istituto Oncologico Veneto-IRCCS, Padua, Italy and University of Milano-Bicocca, Milan, Italy.
Cancer Immunol Immunother DOI 10.1007/s00262-013-1397-7.
185. Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis. Francesco Lolli, Helene Martini, Alessandra Citro, Debora Franceschini, Emilio Portaccio, Maria Pia Amato, Rosella Mechelli, Viviana Annibali, John Sidney, Alessandro Sette, Marco Salvetti and Vincenzo Barnaba. Dipartimento di Scienze Biomediche, Sperimentali e Cliniche and Neurofarba, Università of Firenze, Italy; Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy; Centre for Experimental Neurological Therapies, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sant’Andrea Hospital, Sapienza Università di Roma, Italy; La Jolla Institute for Allergy and Immunology, San Diego, California, USA; Istituto Pasteur, Fondazione Cenci Bolognetti, Rome, Italy and Laboratorio di Virologia Molecolare, Fondazione Andrea Cesa, Rome, Italy. Journal of Neuroinflammation 2013, 10:94 doi:10.1186/1742-2094-10-94.
186. Efficacy and safety of entecavir plus carnitine complex (GODEX®) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: randomized, multicenter open-label trials. The GOAL study. Dae Won Jun, Byung Ik Kim, Yong Kyun Cho, Hong Ju Kim, Young Oh Kwon, Soo Young Park, Sang Young Han, Yang Hyun Baek, Yong Jin Jung, Hwi Young Kim, Won Kim, Jeong Heo, Hyun Young Woo, Seong Gyu Hwang, Kyu Sung Rim, Jong Young Choi, Si Hyun Bae, Young Sang Lee, Young Suck Lim, Jae Youn Cheong, Sung Won Cho, Byung Seok Lee, Seok Hyun Kim, Joo Hyun Sohn, Tae Yeob Kim, Yong Han Paik, Ja Kyung Kim and Kwan Sik Lee. Hanyang University College of Medicine, Seoul, Korea; Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Kyungpook National University Hospital, Kyungpook National University College of Medicine, Daegu, Korea; Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea; SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea; Pusan National University Hospital, Pusan National University College of Medicine, Busan, Korea; CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Korea; Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea; Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Ajou University Hospital, Ajou University College of Medicine, Suwon, Korea; Chungnam National University College of Medicine, Daejeon, Korea; Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea and Gangnam Severance Hospital, Yonsei University College of Medicine, Korea.Clin Mol Hepatol. 2013 Jun;19(2):165-172.
187. Hsp70 vaccination-induced primary immune responses in efferent lymph of the draining lymph node. Manouk Vrielinga, Wiebren Santemaa, Martin Vordermeier, Victor Ruttena and Ad Koetsa. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; TB Research Group, Veterinary Laboratories Agency, Addlestone, United Kingdom and Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, South Africa. doi: 10.1016/j.vaccine.2013.08.021.
188. Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice. Andrea Annoni1, Alessio Cantore, Patrizia Della Valle, Kevin Goudy, Mahzad Akbarpour, Fabio Russo, Sara Bartolaccini, Armando D'Angelo, Maria Grazia Roncarolo and Luigi Naldi. San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy; Vita Salute San Raffaele University, Milan, Italy and Coagulation Service and Thrombosis Research Unit, San Raffaele Scientific Institute, Milan, Italy.
DOI: 10.1002/emmm.201302857.
189. Galectin-9 is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations. Mr. Christopher Ungerer, Mrs. Patricia Christina Quade-Lyssy, Prof. Heinfried H Radeke, Dr. Reinhard Henschler, Dr. Christoph Königs, Prof. Ulrike Köhl, Erhard Seifried, and Dr. Jörg Schüttrumpf. DRK Blood Donor Services Baden-Würtemberg-Hessen, Transfusion medicin and Immune Hematology, Frankfurt, Germany; Clinic of the Johann Wolfgang Goethe University, pharmazentrum Frankfurt, Germany; Ludwig-Maximilian University Munich, Institute for Hematology, Transfusion Medicine and Cell Therapies, Germany; Clinics of the Goethe University Frankfurt am Main, Department of Pediatrics, Germany and Hannover Medical School, Institute of Cellular Therapeutics, Germany. doi:10.1089/scd.2013.0335.
190. Microvesicle cargo of TAA-MUC1 allows cross-presentation and specific carbohydrate processing. Aurelia Rughetti, Hassan Rahimi, Francesca Belleudi, Chiara Napoletano, Federico Battisti, Ilaria Grazia Zizzari, Morena Antonilli, Filippo Bellati, Hans H Wandall, Pierluigi Benedetti Panici, Joy M Burchell, Maria Rosaria Torrisi and Marianna Nuti. University of Rome, La Sapienza, Italy; Copenhagen Center for Glycomics, Denmark and Breast Cancer Biology Group, King's College London, Great Britain. doi:10.1158/2326-6066.CIR-13-0112-T.
191. The HIV-1 Tat Protein Induces the Activation of CD8+ T Cells and Affects In Vivo the Magnitude and Kinetics of Antiviral Responses. Francesco Nicoli, Valentina Finessi, Mariaconcetta Sicurella, Lara Rizzotto, Eleonora Gallerani, Federica Destro, Aurelio Cafaro, Peggy Marconi, Antonella Caputo, Barbara Ensoli and Riccardo Gavioli. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; Department of Molecular Medicine, University of Padova, Padova, Italy; Department of Biomedical Sciences, Azienda Ospedaliero Universitaria Sant'Anna, Ferrara, Italy and National AIDS Center, Istituto Superiore di Sanità, Rome, Italy. PLoS ONE 8(11): e77746. doi:10.1371/journal.pone.0077746.
192. Human cytotoxic T lymphocytes directed to seasonal influenza A viruses cross-react with the newly emerging H7N9 virus. Carolien E. van de Sandt, Joost H.C.M. Kreijtz, Gerrie de Mutsert, Martina M. Geelhoed-Mieras, Marine L.B. Hillaire, Stella E. Vogelzang-van Trierum, Albert D.M.E. Osterhaus, Ron A.M. Fouchiera and Guus F. Rimmelzwaana. Viroscience Lab, ErasmusMC, Rotterdam, The Netherlands and ViroClinics Biosciences BV, Rotterdam, The Netherlands. doi: 10.1128/JVI.02843-13.
193. Nachweis von IFN-γ in Granulozyten bei Morbus Behçet Patienten. Dissertation zur Erlangung des Doktorgrades der Medizin der Medizinischen Fakultät der Eberhard Karls Universität zu Tübingen vorgelegt von Sascha Marc Hoffmann aus Nagold in 2013.
194. Antibody but not memory B-cell responses are tuned-down in vertically HIV-1 infected children and young individuals being vaccinated yearly against influenza. Stefano Rinaldi, Paola Zangari, Nicola Cotugno, Emma Concetta Manno, Noemi Brolatti, Maria Rita Castrucci, Isabella Donatelli, Paolo Rossi and Paolo Palma. Department of System Medicine, University of Rome, Tor Vergata, Italy; University Department of Pediatrics, DPUO, Unit of Immune and Infectious Diseases, Bambino Gesù Children's Hospital, Rome, Italy and WHO National Influenza Centre, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità (ISS), Rome, Italy. doi/10.1016/j.vaccine.2013.12.008.
195. Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production. Alejandro Escobar, Adam Aguirre, María Antonieta Guzmán, Rodrigo González, Diego Catalán, Claudio Acuña-Castillo, Milton Larrondo, Mercedes López, Barbara Pesce, Jennifer Rolland, Robyn O’Hehir and Juan Carlos Aguillón. Faculty of Medicine, University of Chile Millennium Institute on Immunology and Immunotherapy, Santiago, Chile and Institute of Dental Science, Faculty of Dentistry, University of Chile, Santiago, Chile. DOI: 10.1371/journal.pone.0085930.
196. B-cell development and functions and therapeutic options in adenosine deaminase deficient patients. Immacolata Brigida, Aisha V. Sauer, Francesca Ferrua, Stefania Giannelli, Samantha Scaramuzza, Valentina Pistoia, Maria Carmina Castiello, Barbara H. Barendregt, Maria Pia Cicalese, Miriam Casiraghi, Chiara Brombin, Jennifer Puck, Klaus Müller, Lucia Dora Notarangelo, Davide Montin, Joris M. van Montfrans, Maria Grazia Roncarolo, Elisabetta Traggiai, Jacques J.M. van Dongen, Mirjam van der Burg and Alessandro Aiuti. San Raffaele Scientific Institute, Milan, Italy; Tor Vergata University, Rome, Italy; Erasmus MC, University Medical Center, Rotterdam, The Netherlands; University Medical Center Utrecht, The Netherlands; University of California San Francisco, USA; Novartis Institute for Research in Biomedicine, Basel, Switzerland. DOI: 10.1016/j.jaci.2013.12.1043.
197. Humoral and B-cell memory responses in children five years after pertussis acellular vaccine priming. Maria Carollo, Elisabetta Pandolfi, Alberto Eugenio Tozzi, Anne-Marie Buisman, Françoise Mascart and Clara Maria Ausiello. Anti-Infectious Immunity Unit, Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità (ISS), Rome, Italy; Epidemiology Unit, Research Center, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy; Centre for Infectious Disease and Control (CIb), National Institute for Public Health and the Environment, Bilthoven, The Netherlands and Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (ULB), Brussels, Belgium. DOI: 10.1016/j.vaccine.2014.02.005.
198. Untersuchungen von rekombinantem Modifizierten Vaccinavirus Ankara zur Verabreichung von Antigenen des West-Nil-Virus Inaugural. Dissertation zur Erlangung der Würde eines Doktor rer. biol. vet. der Tierärztlichen Fakultät der Ludwig - Maximilians - Universität München von Martina Kaserer. Arbeit angefertigt unter der Leitung von Prof. Dr. med. vet. Gerd Sutter. Tag der Promotion: 8. Februar 2014.
199. Einfluss Zelltod-inhibierender Proteine des murinen Cytomegalovirus auf die Initiation der antiviralen CD8 T-Zellantwort. Dissertation zur Erlangung des Grades Doktor der Natur-wissenschaften am Fachbereich Biologie der Johannes Gutenberg-Universität in Mainz von Stefan Ebert im Januar 2014. Arbeit angefertigt am Institut für Virologie der Universitätsmedizin Mainz unter der Leitung von Prof. Dr. Matthias J. Reddehase.
200. Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regime elicits T cell and neutralizing antibody immune responses. Alicja M. Chmielewska, Mariarosaria Naddeo, Stefania Capone, Virginia Ammendola, Ke Hu, Luke Meredith, Lieven Verhoye, Malgorzata Rychlowska, Rino Rappuoli, Jeffrey B. Ulmer, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Geert Leroux-Roels, Peter Balfe, Krystyna Bienkowska-Szewczyk, Philip Meuleman, Jane A. McKeating and Antonella Folgori. Department of Molecular Virology, University of Gdansk, Gdansk, Polanda; Okairos, Naples, Italy; Centre for Human Virology and NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK; Ghent University, Ghent, Belgium; Novartis Vaccines and Diagnostics, Cambridge, MA, USA, and Siena, Italy; CEINGE, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy; Okairos AG, Basel, Switzerland. doi: 10.1128/JVI.03574-13.
201. Solid Bioneedle-Delivered Influenza Vaccines Are Highly Thermostable and Induce Both Humoral and Cellular Immune Responses. Peter C. Soema, Geert-Jan Willems, Klaas van Twillert, Gijsbert van de Wijdeven, Claire J. Boog, Gideon F. A. Kersten and Jean-Pierre Amorij. Institute for Translational Vaccinology (Intravacc), Bilthoven, The Netherlands and Bioneedle Technologies Group BV, Eindhoven, The Netherlands. DOI: 10.1371/journal.pone.0092806.
202. Dendritic Cell Mediated Immune Humanization of Mice: Implications for Allogeneic and Xenogeneic Stem Cell Transplantation. Gustavo Salguero, Anusara Daenthanasanmak, Christian Münz, Ana Raykova, Carlos A. Guzmán, Peggy Riese, Constanca Figueiredo, Florian Länger, Andreas Schneider, Laura Macke, Bala Sai Sundarasetty, Torsten Witte, Arnold Ganser and Renata Stripecke. Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Germany; Institute of Experimental Immunology University of Zurich, Switzerland; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Department of Transfusion Medicine, Hannover Medical School, Germany; Intitute for Pathology, Hannover Medical School, Germany and Clinic for Immunology and Rheumatology, Hannover Medical School, Germany. The Journal of Immunology April 16, 2014, 1302887.
203. Evaluation of suitable target antigens and immunoassays for high-accuracy immune monitoring of cytomegalovirus and Epstein–Barr virus-specific T cells as targets of interest in immunotherapeutic approaches. Sabine Tischer, Daria Dieks, Cinja Sukdolak,Carola Bunse,Constanca Figueiredo, Stephan Immenschuh, Sylvia Borchers, Renata Stripecke, Britta Maecker-Kolhoff, Rainer Blasczyk and, Britta Eiz-Vesper. Hannover Medical School, Hannover, Germany. doi:10.1016/j.jim.2014.05.011.
204. Targeted genome editing in human repopulating haematopoietic stem cells. Pietro Genovese, Giulia Schiroli, Giulia Escobar, Tiziano Di Tomaso, Claudia Firrito, Andrea Calabria, Davide Moi, Roberta Mazzieri, Chiara Bonini, Michael C. Holmes, Philip D. Gregory, Mirjam van der Burg, Bernhard Gentner, Eugenio Montini, Angelo Lombardo and Luigi Naldini. San Raffaele Scientific Institute, Milan, Italy; Sangamo BioSciences Inc., Richmond, California, USA and Erasmus MC, University Medical Center, Rotterdam, The Netherlands. doi:10.1038/nature13420.
205. B-Sides Serologic Markers of Immunogenicity in Kidney Transplanted Patients: Report From 2012-2013 Flu Vaccination Experience. Rinaldi, Stefano; Cagigi, Alberto; Santilli, Veronica; Zotta, Federica; di Martino, Angela; Castrucci, Maria Rita; Donatelli, Isabella; Poggi, Elvira; Piazza, Antonina; Campana, Andrea; Guzzo, Isabella; Villani, Alberto; Rossi, Paolo; Dello Strologo, Luca; Palma, Paolo. Transplantation, doi: 10.1097/TP.0000000000000209.
206. Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1. Claudia Arenaccio, Chiara Chiozzini, Sandra Columba-Cabezas, Francesco Manfredi and Maurizio Federico. National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; Department of Science, University Roma Tre, Rome, Italy and Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy. Retrovirology 2014, 11:46 doi:10.1186/1742-4690-11-46.
207. LPS-Challenged TNF%uD835%uDEFC Production, Prostaglandin Secretion, and TNF%uD835%uDEFC/TNFRs Expression in the Endometrium of Domestic Cats in Estrus or Diestrus, and in Cats with Pyometra or Receiving Medroxyprogesterone Acetate. Ewelina Jursza, Anna Z. Szóstek, Mariusz P. Kowalewski, Alois Boos, Kiyoshi Okuda, andMarta J. Siemieniuch. Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland; Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Switzerland and Graduate School of Natural Science and Technology, Okayama University, Japan. Mediators of Inflammation Volume 2014, Article ID 689280; http://dx.doi.org/10.1155/2014/689280.
208. NON-SELF T-CELL EPITOPE FUSED TO AN ANTIBODY THAT RECOGNISES A TUMOUR-SPECIFIC CELL-SURFACE RECEPTOR AND USES THEREOF. United States Patent Application 20140161826 from 06/12/2014. Inventors: Pessi, Antonello (Pomezia, IT).
209. Rapid expansion of CD8+ T cells in wildtype and type I interferon receptor deficient mice correlates with protection after low-dose emergency immunization with Modified Vaccinia virus Ankara. Asisa Volz, Martin Langenmayer, Sylvia Jany, Ulrich Kalinke and Gerd Sutter. Institute for Infectious Diseases and Zoonoses, LMU Munich, Germany; Institute for Experimental Infection Research, TWINCORE, - Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz-Centre for Infection Research, Braunschweig, and the Hannover Medical School, Hannover, Germany; Institute of Veterinary Pathology, LMU Munich, Munich, Germany and German Centre for Infection Research (DZIF), partner site Munich. Doi: 10.1128/JVI.00945-14.
210. An Attenuated Herpes Simplex Virus Type 1 (HSV1) Encoding the HIV-1 Tat Protein Protects Mice from a Deadly Mucosal HSV1 Challenge. Mariaconcetta Sicurella, Francesco Nicoli, Eleonora Gallerani, Ilaria Volpi, Elena Berto, Valentina Finessi, Federica Destro, Roberto Manservigi, Aurelio Cafaro, Barbara Ensoli, Antonella Caputo, Riccardo Gavioli and Peggy C. Marconi. Department of Life Sciences and Biotechnology, University of Ferrara, Italy; Department of Molecular Medicine, University of Padova, Italy and National AIDS Center, Istituto Superiore di Sanità, Rome, Italy. DOI: 10.1371/journal.pone.0100844
211. Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN-GAMMA in patients with metastatic melanoma: a randomised "proof-of-principle" phase II study. Francesco de Rosa, Laura Ridolfi, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Oriana Nanni, Massimiliano Petrini, Laura Fiammenghi, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Angela Riccobon, Elisabetta Parisi, Antonino Romeo, Livia Turci and Massimo Guidoboni. Immunotherapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei, Tumori (IRST) IRCCS, Meldola, FC, Italy; Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy; Radiotherapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy and Center for Biological Resources, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, FC, Italy. J Transl Med. 2014 Jul 22;12(1):209.
212. Exosomes from Human Immunodeficiency virus type-1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism. Claudia Arenaccio, Chiara Chiozzini, Sandra Columba-Cabezas, Francesco Manfredi, Elisabetta Affabris, Andreas Baur and Maurizio Federico. National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; Department of Science, University Roma Tre, Rome, Italy; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy and Department of Dermatology, University Hospital Erlangen, Germany. Doi: 10.1128/JVI.01712-14
213. Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection. Weidong Chai, Zhenya Wang, Pawel Janczyk, Sven Twardziok, Ulrike Blohm, Nikolaus Osterrieder and Michael Burwinkel. Institut für Virologie, Freie Universität Berlin, Germany; Bundesinstitut für Risikobewertung, Abteilung für Biologische Sicherheit, Fachgruppe für Molekulare Diagnostik und Genetik, Berlin, Germany and Molekularbiologie und Bioinformatik, Charité - Universitätsmedizin Berlin, Germany and Institut für Immunologie, Friedrich-Loeffler-Institut, Greifswald-Insel Riem, Germany.
Virology Journal 2014, 11:140. doi:10.1186/1743-422X-11-140
214. Differential characteristics of cytotoxic T-lymphocytes restricted by the protective HLA alleles B*27 and B*57 in HIV-1 infection. Schellens, Ingrid M.M. PhD; Spits, Hilde B. MSc; Navis, Marjon PhD; Westerlaken, Geertje H.A. BSc; Nanlohy, Nening M. MSc; Coffeng, Luc E. MSc; Kootstra, Neeltje PhD; Miedema, Frank PhD; Schuitemaker, Hanneke PhD; Borghans, José A.M. PhD; van Baarle, Debbie PhD. JAIDS Journal of Acquired Immune Deficiency Syndromes: Post Acceptance: August 28, 2014; doi: 10.1097/QAI.0000000000000324.
215. Optimization of Mucosal Responses after Intramuscular Immunization with Integrase Defective Lentiviral Vector. Alessandra Rossi, Zuleika Michelini, Pasqualina Leone, Martina Borghi, Maria Blasi, Roberta Bona, Massimo Spada, Felicia Grasso, Alessio Gugliotta, Mary E. Klotman, Andrea Cara and Donatella Negri. Istituto Superiore di Sanità, Rome, Italy and Duke University Medical Center, Durham, North Carolina, United States of America. Published: September 11, 2014; DOI: 10.1371/journal.pone.0107377.
216. Pathogenic IgG Antibodies against Desmoglein 3 in Pemphigus Vulgaris Are Regulated by HLA-DRB1*04:02-Restricted T Cells.Rüdiger Eming, Tina Hennerici, Johan Bäcklund, Claudio Feliciani, Kevin C. Visconti, Sebastian Willenborg, Jessica Wohde, Rikard Holmdahl, Grete Sønderstrup and Michael Hertl. Department of Dermatology and Allergology, Philipps University, Marburg, Germany; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, Italy; and Department of Microbiology and Immunology, School of Medicine, Stanford University, California, USA. The Journal of Immunology September 24, 2014 1401081.
217. Influenza T-cell Epitope-Loaded Virosomes Adjuvanted with CpG as a Potential Influenza Vaccine. Peter C. Soema, Sietske K. Rosendahl Huber, Geert-Jan Willems, Wim Jiskoot, Gideon F. A. Kersten and Jean-Pierre Amorij. Intravacc (Institute for Translational Vaccinology), Bilthoven, The Netherlands; Division of Drug Delivery Technology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands and Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Pharmaceutical Research , doi 10.1007/s11095-014-1556-3.
218. Murine Granulocyte–Macrophage Colony-Stimulating Factor Expressed from a Bicistronic Simian Immunodeficiency Virus-Based Integrase-Defective Lentiviral Vector Does Not Enhance T-Cell Responses in Mice. Michelini Zuleika, Negri Donatella, Biava Mirella, Baroncelli Silvia, Spada Massimo, Leone Pasqualina, Bona Roberta, Blasi Maria, Nègre Didier, Klotman Mary E., and Cara Andrea. Istituto Superiore di Sanità, Rome, Italy; Duke University Medical Center, Durham, North Carolina, USA; CIRI International Center for Infectiology Research, Université de Lyon, France; Inserm, U1111, Lyon, France; Ecole Normale Supérieure de Lyon, France; CNRS, UMR5308, Lyon, France and LabEx Ecofect, Université de Lyon, France. Viral Immunology, doi:10.1089/vim.2014.0062.
219. Biocompatible Anionic Polymeric Microspheres as Priming Delivery System for Effetive HIV/AIDS Tat-Based Vaccines. Fausto Titti, Maria T. Maggiorella, Flavia Ferrantelli, Leonardo Sernicola, Stefania Bellino, Barbara Collacchi, Emanuele Fanales Belasio, Sonia Moretti, Maria Rosaria Pavone Cossut, Roberto Belli, Erika Olivieri, Stefania Farcomeni, Daniela Compagnoni and Barbara Ensoli.National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; I.S.O.F., Consiglio Nazionale delle Ricerche, Bologna, Italy; Department of Molecular Medicine, University of Padova, Padova, Italy. DOI: 10.1371/journal.pone.0111360
220. Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome. Rita Carsetti, Diletta Valentini, Valentina Marcellini, Marco Scarsella, Emiliano Marasco, Ferruccio Giustini, Andrea Bartuli, Alberto Villani and Alberto G. Ugazio.
Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. European Journal of Immunology, DOI: 10.1002/eji.201445049.
221. Human Cytotoxic T Lymphocytes Directed to Seasonal Influenza A Viruses Cross-React with the Newly Emerging H7N9 Virus. Carolien E. van de Sandt, Joost H. C. M. Kreijtz, Gerrie de Mutsert, Martina M. Geelhoed-Mieras, Marine L. B. Hillaire, Stella E. Vogelzang-van Trierum, Albert D. M. E. Osterhaus, Ron A. M. Fouchier and Guus F. Rimmelzwaana. Viroscience Laboratory, Erasmus MC, Rotterdam, The Netherlandsa ViroClinics Biosciences BV, Rotterdam, The Netherlands. J. Virol. 2014, 88(3):1684. DOI: 10.1128/JVI.02843-13.
222. Microvesicle Cargo of Tumor-Associated MUC1 to Dendritic Cells Allows Cross-presentation and Specific Carbohydrate Processing. Aurelia Rughetti, Hassan Rahimi, Francesca Belleudi, Chiara Napoletano, Federico Battisti, Ilaria G. Zizzari, Morena Antonilli, Filippo Bellati, Hans H. Wandall, Pierluigi Benedetti Panici, Joy M. Burchell, Mara R. Torrisi and Marianna Nuti. Departments of Experimental Medicine, Clinic and Molecular Medicine, and Gynaecology, Obstetrics and Urology, "Sapienza" University of Rome, Rome, Italy; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark and Research Oncology, King's College of London, Guy's Hospital, London, United Kingdom. doi: 10.1158/2326-6066.CIR-13-0112-T.
223. A laboratory test based on determination of cytokine profiles: a promising assay to identify exposition to contact allergens and predict the clinical outcome in occupational allergic contact dermatitis. Valentina Bordignon, Francesca Palamara, Giorgia Altomonte, Isabella Sperduti, Mario Pietravalle, Claudia Cavallotti, Paola Cordiali-Fei, Maria Pia Fuggetta, Antonio Cristaudo and Fabrizio Ensoli. Clinical Pathology and Microbiology, San Gallicano Dermatology Institute, Rome, Italy; Allergy and Infectious Diseases, San Gallicano Dermatology Institute, Rome, Italy; Epidermiology, Regina Elena Cancer Institute, Rome, Italy; Clinical Dermatology, San Gallicano Dermatology Institute, Rome, Italy and Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy. BMC Immunology, doi:10.1186/s12865-015-0066-3.
224. The LALF32-51 peptide as component of HPV therapeutic vaccine circumvents the alum-mediated inhibition of IL-12 and promotes a Th1 response. Milaid Granadillo,Alain B. Alfonso,Maribel G. Vallespi, Aileen Batte, Yordanka Soria, Enma Brown, Miladys Limonta, Yayrí C. Prieto, Laura Varas and Isis Torrens. Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba. Journal of Cellular Immunotherapy, doi:10.1016/j.jocit.2015.01.001.
225. Immunogenicity of gx301 cancer vaccine: Four (telomerase peptides) is better than one. Daniela Fenoglio, Alessia Parodi, Rosa Lavieri, Francesca Kalli, Francesca Ferrera, Augusto Tagliamacco, Andrea Guastalla, Maria Giuseppina Lamperti, Mauro Giacominia and Gilberto Filaci. Centre of Excellence for Biomedical Research , University of Genoa , Italy. Human Vaccines & Immunotherapeutics, DOI: 10.1080/21645515.2015.1012032.
226. Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice. Georgia Fousteri, Tatiana Jofra, Roberta Di Fonte, Nicola Gagliani, Cristina Morsiani, Angela Stabilini and Manuela Battaglia. Divison of Immunology Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy. Diabetologia, DOI.10.1007/s00125-015-3540-9.
227. Retinoic Acid Promotes Mucosal and Systemic Immune Responses after Mucosal Priming and Systemic Boosting in Mice. Elisa Cirelli, Antonella Riccomi, Filippo Veglia, Valentina Gesa, Maria Teresa De Magistris and Silvia Vendetti. Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy and Animal Breeding Department (STA), University of Rome Tor Vergata, Rome, Italy. J Vaccines Vaccin 6: 265. doi: 10.4172/2157-7560.1000265.
228. Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein. Asisa Volz, Alexandra Kupke, Fei Song, Sylvia Jany, Robert Fux, Hosam Shams-Eldin, Jörg Schmidt, Christin Becker, Markus Eickmann, Stephan Becker and Gerd Sutter. German Centre for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich,Germany; German Centre for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany; University of Giessen Lung Center, Department of Internal Medicine II, Section of Infectious Diseases, Giessen, Germany. Journal of Virology, doi: 10.1128/JVI.00614-15.
229. A pilot study in prostate cancer patients treated with the AE37 Ii-key-HER-2/neu polypeptide vaccine suggests that HLA-A*24 and HLA-DRB1*11 alleles may be prognostic and predictive biomarkers for clinical benefit. Eleftheria A. Anastasopoulou, Ioannis F. Voutsas, Theodora Keramitsoglou, Cécile Gouttefangeas, Hubert Kalbacher, Anastasios Thanos, Michael Papamichail, Sonia A. Perez and Constantin N. Baxevanis. Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, Athens, Greece; Immunobiology Department, Helena Venizelou Maternity Hospital, Athens, Greece; Department of Immunology, Institute for Cell Biology, Eberhard-Karls University, Tübingen, Germany; Interfaculty Institute of Biochemistry, Eberhard-Karls University, Tübingen, Germany; Urology Department, Saint Savas Cancer Hospital, Athens, Greece. Cancer Immunology, Immunotherapy, 31. May 2015, DOI:10.1007/s00262-015-1717-1.
230. Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients. Maria Grazia Cusi, Cirino Botta, Pierpaolo Pastina, Maria Grazia Rossetti, Elena Dreassi, Giacomo Maria Guidelli, Antonella Fioravanti, Elodia Claudia Martino, Claudia Gandolfo, Marco Pagliuchi, Assunta Basile, Salvatore Francesco Carbone, Veronica Ricci, Lucia Micheli, Pierfrancesco Tassone, Pierosandro Tagliaferri, Luigi Pirtoli and Pierpaolo Correale. Department of Medical Biotechnologies, Siena University, Siena, Italy; Department of Experimental and Clinical Medicine, Catanzaro Magna Graecia University and Medical Oncology Unit, Catanzaro, Italy; Unit of Radiotherapy, Department of Medical, Surgical Sciences and Neurosciences, Siena University, Siena, Italy; Unit of Pharmacy, Siena University Hospital, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, Siena University, Siena, Italy; Unit of Rheumatology, Siena University Hospital, Siena, Italy; Unit of Psychology, Siena University Hospital, Siena, Italy; Unit of Radiology, Siena University Hospital, Siena, Italy; Department of Medical, Surgical Sciences, Neurosciences Siena University, Siena, Italy. Cancer Immunology, Immunotherapy, 2. June 2015, DOI: 10.1007/s00262-015-1711-7.
231. Lentiviral protein transfer vectors are an efficient vaccine-platform inducing strong antigen-specific cytotoxic T cell response. Katharina M. Uhlig, Stefan Schülke, Vivian A.M. Scheuplein, Anna H. Malczyk, Johannes Reusch, Stefanie Kugelmann, Anke Muth, Vivian Koch, Stefan Hutzler, Bianca S. Bodmer, Axel Schambach, Christian J. Buchholz, Zoe Waibler, Stephan Scheurer and Michael D. Mühlebach. Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany; German Cancer Consortium, Heidelberg, Germany; Novel Vaccination Strategies and Early Immune Responses, Paul-Ehrlich-Institut, Langen, Germany. Journal of Virology, doi: 10.1128/JVI.00844-15
232. Improved Natural Killer cell activity and retained anti-tumor CD8+ T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy. E Muraro, E Comaro, R Talamini, E Turchet, G Miolo, S Scalone, L Militello, D Lombardi, S Spazzapan, T Perin, S Massarut, D Crivellari, Riccardo Dolcetti and D Martorelli. IRCCS, National Cancer Institute, Aviano, Italy. Journal of Translational Medicine, June 2015, 13:204.
233. Role of Suppressor of Cytokine Signaling 3 in the Immune Modulation of Mesenchymal Stromal Cells. Chen Yang, Chunquan Zheng, Hai Lin, Jing Li and Keqing Zhao. Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China; Department of Otolaryngology, Ruijin Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Otolaryngology, The Sixth People’s Hospital, School of medicine, Shanghai Jiao tong University, Shanghai, China; Department of Otolaryngology, First People’s Hospital of Hangzhou City, Hangzhou, Zhejiang Province, China. Inflammation, DOI: 10.1007/s10753-015-0246-6.
234. Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2+ mammary cancer. Sarah Jacca, Valeria Rolih, Elena Quaglino, Valentina Franceschi, Giulia Tebaldi, Elisabetta Bolli, Alfonso Rosamilia, Simone Ottonello, Federica Cavallo and Gaetano Donofrio. Department of Medical-Veterinary Science, University of Parma, Parma, Italy; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy; Department of Life Sciences, Biochemistry and Molecular Biology Unit, University of Parma, Parma, Italy. OncoImmunology, DOI: 10.1080/2162402X.2015.1082705.
235. Differential recognition of influenza A viruses by M158-66 epitope-specific CD8+ T cells is determined by extra-epitopic amino acid residues. Carolien E. van de Sandt, Joost H.C.M. Kreijtz, Martina M. Geelhoed-Mieras, Nella J. Nieuwkoop, Monique I. Spronken, David A.M.C. van de Vijver, Ron A.M. Fouchier, Albert D.M.E. Osterhaus and Guus F. Rimmelzwaana. Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands and ViroClinics Biosciences BV, Rotterdam, The Netherlands. doi: 10.1128/JVI.02439-15
236. The presence of protective cytotoxic T lymphocytes does not correlate with shorter lifespans of productively infected cells in HIV-1 infection. Spits, Hilde B; Mudrikova, Tania; Schellens, Ingrid M.M.; Wensing, Annemarie M.J.; Prins, Jan M.; Feuth, Thijs; Spierings, Erik; Nijhuis, Monique; van Baarle, Debbie; Borghans, José A.M.. AIDS: 2 January 2016, doi: 10.1097/QAD.0000000000000914.
237. H5N1 Protection by Seasonal Influenza Vaccine in Homologous and Heterologous Prime/Boost Vaccination. Roos A, Roozendaal R, Riahi SD, Vreugdenhil J, Vaneman J, Dekking L, Koldijk M, Goudsmit J and Radosevic K. Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands; Janssen Prevention Center, Center of Excellence within Janssen Research & Development, Janssen, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands; Sanofi, Global Biotherapeutics, Vitry-sur-Seine, France. J Vaccines Vaccin 2015, 6:5, doi: 2157-7560.1000299.
238. USE OF REPLICATION DEFICIENT HSV-1 AS A VACCINE VECTOR FOR THE DELI VARY OF HIV-1 TAT ANTIGEN. Abstract: A vaccine for a DNA virus, especially HSV1, comprises an expression vector for HIV1 Tat, wherein the vector is an avirulent form of said DNA virus, and elicits cellular responses to cryptic epitopes of the DNA virus, as well as eliciting a detectable IgG response. United States Patent Application 20150359878. Inventors: Marconi, Peggy (Ferrara, IT); Caputo, Antonella (Ferrara, IT); Gavioli, Riccardo (Ferrara, IT); Ensoli, Barbara (Roma, IT); Manservigi, Roberto (Ferrara, IT). Applicant: VAXXIT SR (Roma, IT). Publication Date: 17/12/2015.
239. IMPROVED POXVIRAL VACCINES. Abstract: The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed. United States Patent Application 20160000904 Inventors: Colloca, Stefano (Rome, IT); Cortese, Riccardo (Basel, CH); Folgori, Antonella (Rome, IT); Nicosia, Alfredo (Rome, IT). Applicant: GLAXOSMITHKLINE BIOLOGICALS SA (Rixensart, BE). Publication Date: 01/07/2016.
240. Triple peptide vaccination as consolidation treatment in women affected by ovarian and breast cancer: Clinical and immunological data of a phase I/II clinical trial. Morena Antonilli, Hassan Rahimi, Valeria Visconti, Chiara Napoletano, Ilary Ruscito, Ilaria Grazia Zizzari, Salvatore Caponnetto, Giacomo Barchiesi, Roberta Iadarola, Luca Pierelli, Aurelia Rughetti, Filippo Bellati, Pierluigi Benedetti Panici and Marianna Nuti. Department of Gynecology, Obstetrics and Urology, Sapienza University of Rome and Department of Experimental Medicine Sapienza University of Rome, Italy. International Journal of Oncology, Published online on: Monday, February 8, 2016.
241. Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus. Tina Hennerici, Robert Pollmann, Thomas Schmidt, Maria Seipelt, Björn Tackenberg, Christian Möbs, Kamran Ghoreschi, Michael Hertl and Rüdiger Eming. Department of Dermatology and Allergology, Philipps University Marburg, Marburg, Germany. DOI: 10.1371/journal.pone.0148919.
242. Immunogenicity and protective efficacy of recombinant Modified Vaccinia virus Ankara candidate vaccines delivering West Nile virus envelope antigens. Asisa Volz, Stephanie Lim, Martina Kaserer, Anna Lülf, Lisa Marr, Sylvia Jany, Cornelia A. Deeg, Gorben P. Pijlman, Penelope Koraka, Albert D.M.E. Osterhaus. German Centre for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Germany; Viroscience Lab, Erasmus Medical Center, Rotterdam, The Netherlands; Artemis One Health Research Institute, Utrecht, The Netherlands; Institute for Animal Physiology, LMU University of Munich, Germany and Laboratory of Virology, Wageningen University, The Netherlands. Vaccine, Volume 34, Issue 16, Pages 1915-1926.
243. INDUCED DENDRITIC CELLS AND USES THEREOF. Abstract: The present invention relates to cells engineered to express at least one cytokine and at least one antigen which induces the self differentiation of dendritic cell (DC) progenitor cells into functional antigen-presenting induced DC (iDC). Moreover, therapeutic uses of said iDC for regenerating the immune system after transplantation of hematopoietic stem cells are disclosed. Said iDC are also useful for generating mice with a functional endogenously regenerated humanized immune system producing antigen-specific T and B cell responses which can be used as animal models for the study of the human adaptive immune responses. United States Patent Application 20160038541. Inventors: Stripecke, Renata (Hannover, DE), Salguero-lopez, Gustavo (Hannover, DE), Daenthanasanmak, Anusara (Hannover, DE) and Ganser, Arnold (Hannover, DE). Applicant: MEDIZINISCHE HOCHSCHULE HANNOVER (Hannover, DE). Publication Date: 02/11/2016.
244. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Tania Løve Aaes, Agnieszka Kaczmarek, Tinneke Delvaeye, Bram De Craene, Stefaan De Koker, Liesbeth Heyndrickx, Iris Delrue, Joachim Taminau, Bartosz Wiernicki, Philippe De Groote, Abhishek D. Garg, Luc Leybaert, Johan Grooten, Mathieu J.M. Bertrand, Patrizia Agostinis, Geert Berx, Wim Declercq, Peter Vandenabeele, Dmitri V. Krysko. Molecular Signaling and Cell Death Unit, Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Cancer Research Institute Ghent (CRIG), Ghent University, Belgium; Physiology Group, Department of Basic Medical Sciences, Ghent University,Belgium. Molecular and Cellular Oncology Unit, Inflammation Research Center, Ghent, Belgium; Department of Pharmaceutics, Ghent University, Belgium. Cell Death Research and Therapy Lab, Department of Cellular and Molecular Medicine, KU Leuven - University of Leuven, Belgium; Methusalem Program, Ghent University, Belgium. DOI: http://dx.doi.org/10.1016/j.celrep.2016.03.037.
245. Reduced Number of Transitional and Naive B Cells in Addition to Decreased BAFF Levels in Response to the T Cell Independent Immunogen Pneumovax®23. Alena Roth, Stephanie Glaesener, Katharina Schütz, Almut Meyer-Bahlburg. Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany. DOI: http://dx.doi.org/10.1371/journal.pone.0152215
246. Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells. Alessandra Tuccitto, Marcella Tazzari, Valeria Beretta, Francesca Rini, Claudia Miranda, Angela Greco, Mario Santinami, Roberto Patuzzo, Barbara Vergani, Antonello Villa, Giacomo Manenti, Loredana Cleris, Daniele Giardiello, Malcolm Alison, Licia Rivoltini, Chiara Castelli and Michela Perego. Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy: Molecular Mechanism Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Melanoma and Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Consorzio MIA (Microscopy and Image Analysis), University of Milano-Bicocca, Italy; Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy and Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Stem Cells, DOI: 10.1002/stem.2413.
247. Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance. Sietske K. Rosendahl Huber , Jolien J. Luimstra, Josine van Beek, Rieuwert Hoppes, Ronald H. J. Jacobi, Marion Hendriks, Kim Kapteijn, Casper Ouwerkerk, Boris Rodenko, Huib Ovaa and Jørgen de Jonge. Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment,Bilthoven, the Netherlands; Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Institute for Chemical Immunology (ICI), Utrecht, the Netherlands. PLOS ONE, DOI:10.1371/journal.pone.0156462, June 22, 2016.
248. Monitoring of adenovirus (ADV)-specific T cells in a boy with ADV pneumonia and disseminated disease after lung transplantation. R.E. Schultze-Florey, S. Tischer, N. Schwerk, A. Heim, B. Eiz-Vesper and B. Maecker-Kolhoff. Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany; Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany; Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany and Institute of Virology, Hannover Medical School, Hannover, Germany. Transplant Infectious Disease, DOI: 10.1111/tid.12569.
249. H5N1 protection by seasonal influenza vaccine in homologous and heterologous prime/boost vaccination. Anna Roos, Ramon Roozendaal, Sarra Damman- Riahi, Jessica Vreugdenhil, Joost Vaneman, Liesbeth Dekking, Martin Koldijk, Jaap Goudsmit and Katarina Radosevic. Faculty of Medicine, University of Amsterdam, The Netherlands. Journal of Vaccines and Vaccination, DOI: 2157-7560.1000299.
250. Improving the cellular immunogenicity of recombinant Modified Vaccinia virus Ankara using green fluorescent protein as model system. Inaugural Dissertation zur Erlangung der Doktorwürde der Tierärztlichen Fakultät der Ludwig Maximilians Universität München, Lehrstuhl für Virologie, von Lisa Susanne Marr. Arbeit angefertigt unter der Leitung von: Univ. Prof. Dr. Gerd Sutter. Mitbetreuung durch: Dr. Asisa Volz. Tag der Promotion: 16. Juli 2016.
251. Combination of TLR1/2 and TLR3 ligands enhances CD4+ T cell longevity and antibody responses by modulating type I IFN production. Bo Ryeong Lee, Soo Kyung Jeong, Byung Cheol Ahn, Byeong-Jae Lee, Sung Jae Shin, Jung Sun Yum and Sang-Jun Ha. Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul, Republic of Korea; R&D Center, CHA Vaccine Institute, Seongnam-si, Gyeonggi, Republic of Korea; Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeollabuk-do, Republic of Korea; Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea. Scientific Reports,doi:10.1038/srep32526.
252. Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing. Anouk C.M. Platteel, A. Marit de Groot, Christin Keller, Peter Andersen, Huib Ovaa, Peter M. Kloetzel Michele Mishto and Alice J.A.M. Sijts. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Institut für Biochemie, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; d Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark and Department of Chemical Immunology, Leiden University Medical Center, Leiden, The Netherlands. Vaccine, doi:10.1016/j.vaccine.2016.08.039.
253. Protection of mice against the highly pathogenic VVIHD-J by DNA and fowlpox recombinant vaccines, administered by electroporation and intranasal routes, correlates with serum neutralizing activity. Massimiliano Bissa, Elena Quaglino, Carlo Zanotto, Elena Illiano, Valeria Rolih, Sole Pacchioni, Federica Cavallo, Carlo De Giuli Morghen and Antonia Radaelli. Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Italy; Department of Medical Biotechnologies and Translational Medicine, University of Milan, Italy; Catholic University Our Lady of Good Counsel, Tirana, Albania; Cellular and Molecular Pharmacology Section, National Research Council (CNR) Institute of Neurosciences, University of Milan, Italy and f National Institutes of Health, National Cancer Institute (NCI), National Institutes of Health, Basic Research Laboratories, Bethesda, MD, USA. Doi: 10.1016/j.antiviral.2016.09.002.
254. Waning of vaccine-induced immunity to measles in kidney transplanted children. Rocca, Salvatore BSc; Santilli, Veronica MD; Cotugno, Nicola MD; Concato, Carlo BSc; Manno, Emma Concetta MD; Nocentini, Giulia MD; Macchiarulo, Giulia MD; Cancrini, Caterina MD, PhD; Finocchi, Andrea MD, PhD; Guzzo, Isabella MD; Dello Strologo, Luca MD; Palma, Paolo MD, PhD. Department of Public Health, University of Rome Tor Vergata; Academic Department of Pediatrics (DPUO), Bambino Gesù Children's Hospital-Research Institute (IRCCS); Virology Unit, Bambino Gesù Children's Hospital-Research Institute (IRCCS); Nephrology Unit, Bambino Gesù Children's Hospital-Research Institute (IRCCS); Research Unit in Congenital and Perinatal Infections, Bambino Gesù Children's Hospital-Research Institute (IRCCS), Rome, Italy. Doi: 10.1097/MD.0000000000004738.
255. The CD8+ T Cell-Mediated Immunity Induced by HPV-E6 Uploaded in Engineered Exosomes Is Improved by ISCOMATRIXTM Adjuvant. Francesco Manfredi, Paola di Bonito, Barbara Ridolfi, Simona Anticoli, Claudia Arenaccio, Chiara Chiozzini, Adriana Baz Morelli and Maurizio Federico. National AIDS Center, Istituto Superiore di Sanità, Rome, Italy; Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy; Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy; CSL, Ltd., Bio21 Institute, Melbourne, Australia. Vaccines 2016, 4(4), 42; doi:10.3390/vaccines4040042.
256. Unraveling the role of preexisting immunity in prostate cancer patients vaccinated with a HER-2/neu hybrid peptide. Ioannis F. Voutsas, Eleftheria A. Anastasopoulou, Panagiotis Tzonis, Michael Papamichail, Sonia A. Perez and Constantin N. Baxevanis. Cancer Immunology and Immunotherapy Center, Saint Savas Cancer Hospital, Athens, Greece. Journal for ImmunoTherapy of Cancer20164:75 DOI: 10.1186/s40425-016-0183-4
257. B-cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. Anika Habener, Ann-Kathrin Behrendt, Jelena Skuljec, Adan Chari Jirmo, Almut Meyer-Bahlburg und Gesine Hansen. Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL); Department of Paediatrics, University Medicine Greifswald, Germany. European Journal of Immunology, DOI: 10.1002/eji.201646518.
258. IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. Leonie Brockmann, Nicola Gagliani, Babett Steglich, Anastasios D. Giannou, Jan Kempski, Penelope Pelczar, Maria Geffken, Bechara Mfarrej, Francis Huber, Johannes Herkel, Yisong Y. Wan, Enric Esplugues, Manuela Battaglia, Christian F. Krebs, Richard A. Flavelland Samuel Huber. I.Medizinische Klinik, Universitätsklinikum Hamburg–Eppendorf, Germany;Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg–Eppendorf, Germany;Institut für Transfusionsmedizin, Zentrum für Diagnostik, Universitätsklinikum Hamburg–Eppendorf, Germany;Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy;Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA;Department of Immunobiology, Yale University, School of Medicine, New Haven, USA;III. Medizinische Klinik, Universitätsklinikum Hamburg–Eppendorf, Germany and Howard Hughes Medical Institute, Chevy Chase, USA. The Journal of Immunology, DOI: 10.4049/jimmunol.1601045
259. Th17-skewed immune response and cluster of differentiation 40 ligand expression in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis. Jessica Freundt-Revilla, Arianna Maiolini, Regina Carlson, Martin Beyerbach, Kai Rentmeister, Thomas Flegel, Andrea Fischer and Andrea Tipold. Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany; Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, LMU Munich, Germany; Institute for Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Germany; Department of Small Animal Medicine, University of Leipzig. Journal of Neuroinflammation, DOI: 10.1186/s12974-016-0784-3
260. Gliadin-Specific CD8+ T Cell Responses Restricted by HLA Class I A*0101 and B*0801 Molecules in Celiac Disease Patients. Stefania Picascia, John Sidney, Alessandra Camarca, Giuseppe Mazzarella, Nicola Giardullo, Luigi Greco, Renata Auricchio, Salvatore Auricchio, Riccardo Troncone, Alessandro Sette and Carmen Gianfrani. Institute of Protein Biochemistry,National Research Council, Naples, Italy; La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA; Institute of Food Sciences, National Research Council, Avellino, Italy; Gastroenterology Unit, Hospital Moscati, Avellino, Italy; Department of Translational Medical Science and European Laboratory for Investigation and Food-Induced Diseases, University Federico II, Naples, Italy; J Immunol, DOI: 10.4049/jimmunol.1601208
261. Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails. Frank A.W. Verreck, Elma Z. Tchilian, Richard A.W. Vervenne, Claudia C. Sombroek, Ivanela Kondova, Okke A. Eissen, Vinod Sommandas, Nicole M. van der Werff, Ernst Verschoor, Gerco Braskamp, Jaco Bakker, Jan A.M. Langermans, Peter J. Heidt, Tom H.M. Ottenhoff, Klaas W. van Kralingen, Alan W. Thomas, Peter C.L. Beverley and Clemens H.M. Kocken. Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; The Peter Medawar Building for Pathogen Research, University of Oxford, UK; Department of Infectious Diseases, Leiden University Medical Centre (LUMC), Leiden, The Netherlands; Department of Pulmonology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands. DOI: 10.1016/j.tube.2017.02.003
262. Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression. Bechara Mfarrej, Eleonora Tresoldi, Angela Stabilini, Alessia Paganelli, Rossana Caldara, Antonio Secchi and Manuela Battaglia. Diabetes Research Institute (DRI), IRCCS San Raffaele Scientific Institute, Milano, Italia; Human T Cell Laboratory, Saint Vincent’s Institute of Medical Research,Victoria, Australia. Journal of Translational Medicine, DOI: 10.1186/s12967-017-1133-8.
263. Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease.Khan, S., Oosterhuis, K., Wunderlich, K., Bunnik, E. M., Bhaggoe, M., Boedhoe, S., Karia, S., Steenbergen, R. D.M., Bosch, L., Serroyen, J., Janssen, S., Schuitemaker, H., Vellinga, J., Scheper, G., Zahn, R. and Custers, J. Janssen Vaccines and Preventions BV, CA, Leiden, The Netherlands; Department of Pathology, VU University Medical Center Amsterdam, The Netherlands. International Journal of Cancer, DOI: 10.1002/ijc.30679V
264. Trans-dissemination of exosomes from HIV-1-infected cells fosters both HIV-1 trans-infection in resting CD4+ T lymphocytes and reactivation of the HIV-1 reservoir.Chiara Chiozzini, Claudia Arenaccio, Eleonora Olivetta, Simona Anticoli, Francesco Manfredi, Flavia Ferrantelli, Gabriella d’Ettorre, Ivan Schietroma, Mauro Andreotti and Maurizio Federico. National Center for Global HealthIstituto Superiore di Sanità, Rome, Italy and Department of Public Health and Infectious Diseases Sapienza University of Rome, Italy. Archives of Virology, DOI: 10.1007/s00705-017-3391-4.
265. Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study. Bala S. Sundarasetty, Valery Volk, Sebastian J. Theobald, Susanne Rittinghausen, Dirk Schaudien, Vanessa Neuhaus, Constanca Figueiredo, Andreas Schneider, Laura Gerasch, Adele Mucci, Thomas Moritz, Constantin von Kaisenberg, Loukia M. Spineli, Katherina Sewald, Armin Braun, Henning Weigt, Arnold Ganser and Renata Stripecke. Hannover Medical School, Hannover, Germany and Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Germany. The American Journal of Pathology, DOI: 10.1016/j.ajpath.2017.02.015.
266. B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation. Christine Happle, MD/PhD; Adan Chari Jirmo, PhD; Almut Meyer-Bahlburg, MD; Anika Habener, PhD; Heinz Gerd Hoymann, PhD; Christian Hennig, MD; Jelena Skuljec, PhD and Gesine Hansen, MD. Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Germany; Department of Pediatrics, University Medicine Greifswald, Greifswald, Germany and Working Group for Airway Pharmacology, Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Germany. DOI: j.jaci.2017.03.051
267. Th2-related immune responses by the Brucella abortus cellular antigens, malate dehydrogenase, elongation factor, and arginase. Young Bin Im, Soojin Shim, Woo Bin Park, Suk Kim and Han Sang Yoo. Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea and College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea. DOI: j.micpath.2017.06.019.
268. Lack of immunogenicity of hydrolysed wheat flour in patients with coeliac disease after a short-term oral challenge. R. Mandile, S. Picascia, C. Parrella, A. Camarca, M. Gobbetti, l: Greco, R. Troncone, C. Gianfrani and R. Auricchio. Department of Medical Translational Sciences, Section of Pediatrics, University of Naples, Federico II, Italy; Institute of Protein Biochemistry, CNR, Naples, Italy; Faculty of Science and Technology, Free University of Bozen, Bozen, Italy; Institute of Food Sciences, CNR, Avellino, Italy; European Laboratory for the Food Induced Diseases (E.L.F.I.D), University of Naples Federico II, Naple, Italy. DOI: 10.1111/apt.14175.
269. Increased, durable B-cell and ADCC Responses Associated with T-helper Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. Willy M.J.M. Bogers, Susan W. Barnett, Herman Oostermeijer, Ivonne G. Nieuwenhuis, Niels Beenhakker, Daniella Mortier, Petra Mooij, Gerrit Koopman, Edmund Remarque, Gregoire Martin, Rachel Pei-Jen Lai, Antu K. Dey, Yide Sun, Brian Burke, Guido Ferrari, David Montefiori, Loic Martin, David Davis, Indresh Srivastava and Jonathan L. Heeney. Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands; CEA, Joliot, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France; Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom; Novartis Vaccines and Diagnostics Corporation, Emeryville, California, USA and Duke University Medical Center, Durham, North Carolina, USA. Journal of Virology 10.1128/JVI.00811-17.
270. Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation. Paola Di Bonito,Chiara Chiozzini,Claudia Arenaccio,Simona Anticoli,Francesco Manfredi,Eleonora Olivetta,Flavia Ferrantelli,Emiliana Falcone, Anna Ruggieri and Maurizio Federico. Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy and Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy. International Journal of Nanomedicie, doi: 10.2147/IJN.S131309.
271. A synthetic human cytomegalovirus pp65-IE1 fusion antigen efficiently induces and expands virus specific T cells. Ellen K.Linka, Christine Brandmüller, Yasemin Suezer, Stefanie Ameres, Asisa Volz, Andreas Moosmann, Gerd Sutter and Michael H.Lehmann. Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-Universität München, Munich, Germany; Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany; Helmholtz Zentrum München, Research Unit Gene Vectors, Munich, Germany and German Center for Infection Research (DZIF), Germany. Doi: 10.1016/j.vaccine.2017.08.019.
272. Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy. Michela Milani, Andrea Annoni, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Tiziano Di Tomaso, Andrea Raimondi, Johannes Lengler, Michael C Holmes, Friedrich Scheiflinger, Angelo Lombardo, Alessio Cantore and Luigi Naldini. San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Milan, Italy; Baxalta (former Baxter) Innovation GmbH, Vienna, Austria and Sangamo Therapeutics, Inc., Richmond, CA, USA.
Doi: 10.15252/emmm.201708148.
273. Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults. Marieke van der Heiden, Aafke Duizendstra, Guy A.M.Berbers, Annemieke M.H.Boots, Anne-Marie Buisman. Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands and Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. Doi: 10.1016/j.vaccine.2017.08.056.
274. METHOD AND KIT FOR THE PREDICTIVE PROGNOSIS OF RESPONSIVENESS TO TREATMENTS OF AUTOIMMUNE DISEASES. United States Patent Application 20170261505. Inventors: Barnaba, Vincenzo (Roma, IT). Publication Date: 09/14/2017. Assignee: UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA" (Roma, IT).
275. Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells. Federico Battisti1, Chiara Napoletano, Rahimi Koshkaki, Francesca Belleudi, Grazia Zizzari, Ilary Ruscito, Palchetti, Filippo Bellati, Pierluigi, Benedetti Panici, Maria Rosaria Torrisi, Giulio Caracciolo, Fabio Altieri, Marianna Nuti and Aurelia Rughetti. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy; Department of Molecular and Clinical Medicine, Instituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy; Department of Gynaecology, Obstetrics and Urology, Sapienza University of Rome, Rome, Italy; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy; Azienda Ospedaliera Sant’Andrea, Rome, Italy and Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome, Italy. Doi: 10.3389/fimmu.2017.01179.
276. Influenza-derived peptides cross-react with allergens and provide asthma protection. Chrysanthi Skevaki, MD, PhD, Christoph Hudemann, PhD, Mikhail Matrosovich, PhD, Christian Möbs, PhD, Sinu Paul, PhD, Andreas Wachtendorf, Bilal Alashkar Alhamwe, BSc, Daniel P. Potaczek, MD, PhD, Stefanie Hagner, PhD, Diethard Gemsa, MD, Holger Garn, PhD, Alessandro Sette, PhD and Harald Renz, MD. Institute of Laboratory Medicine, Philipps University Marbur, Germany; Institute of Virology, Philipps University Marburg, Germany; Department of Dermatology and Allergology, Philipps University Marburg, Germany and La Jolla Institute for Allergy and Immunology, California, USA. Doi: 10.1016/j.jaci.2017.07.056.
277. POXVIRAL VACCINES. United States Patent Application 20170333550. Inventors: Colloca, Stefano (Rome, IT), Cortese, Riccardo (Basel, CH), Folgori, Antonella (Rome, IT), Nicosia, Alfredo (Rome, IT). Application Number: 15/461978. Publication Date: 11/23/2017. Assignee: GLAXOSMITHKLINE BIOLOGICALS, SA (Rixensart, BE).
278. A novel peptide-based vaccine candidate with protective efficacy against influenza A in a mouse model. José Herrera-Rodriguez, Tjarko Meijerhof, Hubert G. Niesters, Grete Stjernholm, Arnt-Ove Hovden, Birger Sørensen, Mats Ökvist, Maja A. Sommerfelt and Anke Huckriede. Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherland and Bionor Pharma AS, Oslo, Norway. Virology, Volume 515, Issue null, Pages 21-28.
279. E3L and F1L Gene Functions Modulate the Protective Capacity of Modified Vaccinia Virus Ankara Immunization in Murine Model of Human Smallpox. Asisa Volz, Sylvia Jany, Astrid Freudenstein, Markus Lantermann, Holger Ludwig and Gerd Sutter. Lehrstuhl für Virologie, Institut für Infektionsmedizin und Zoonosen, Ludwig-Maximilians-Universität München, Munich, Germany; Deutsches Zentrum für Infektionsforschung (DZIF), Munich, Germany and Division of Virology, Paul-Ehrlich-Institut, Langen, Germany. Viruses 2018, 10(1), 21; doi:10.3390/v10010021.
280. Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation. Sumera Y. Younis, Christophe Barnier-Quer, Simon Heuking, Vinod Sommandas, Livia Brunner, Nicole vd.Werff, Patrice Dubois, Martin Friede, Clemens Kocken, Nicolas Collin and Ed Remarque. Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands; Vaccine Formulation Laboratory, University of Lausanne, Epalinges, Switzerland; WHO, Geneva, Switzerland. BMC Immunology, doi: 10.1186/s12865-018-0245-0.
281. A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates. Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D. Giavedoni, Jean L. Patterson, Chad E. Mire, Thomas W. Geisbert, Jay W. Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker and Roland Zahn. Janssen Vaccines & Prevention B.V., Leiden, Netherlands; Bavarian Nordic GmbH, Martinsried, Germany; University of Texas Medical Branch, Galveston, Texas, United States of America; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America. Doi: 10.1371/journal.pone.0192312.
282. Variation at extra-epitopic amino acid residues influences suppression of influenza virus replication by M158-66 epitope-specific CD8+ T lymphocytes. Carolien E. van de Sandt, Mark R. Pronk, Carel A. van Baalen, Ron A.M. Fouchier and Guus F. Rimmelzwaan. Department of Viroscience, ErasmusMC, Rotterdam, The Netherlands and Viroclinics Biosciences BV, Rotterdam, The Netherlands. Doi: 10.1128/JVI.00232-18.
283. COMPOSITION FOR USE IN TREATING CELIAC DISEASE. A method of preparation of a composition including extracellular vesicles derived from stem cells mesenchymal isolated from chorion of human placenta, said method being including: a step of extraction of extracellular vesicles from stem cells mesenchymal, said cells being derived from chorion in advance separated from the placenta in a step of separation chorion-placenta, and a step of sterilization and elimination of contaminating proteins from a semi-finished fluid containing said extracellular vesicles, wherein said step of sterilization and elimination of contaminating proteins comprises a first step of ultracentrifugation of the said semi-finished fluid, and wherein said first step of ultracentrifugation is performed following of a phase of filtration of the said semi-finished fluid. United States Patent Application 20180116956. Inventors: Ciccocioppo, Rachele (Pavia, IT). Application Number: 15/563880. Publication Date: 05/03/2018. Assignee: STEGI-RA TRUST (Paradiso, CH).
284. Skewing effect of sulprostone on dendritic cell maturation compared with dinoprostone. Jenny Bulgarelli, Laura Fiammenghi, Serena Cassan, Anna Maria Granato, Massimiliano Petrini, Elena Pancisi, Valentina Soldati, Francesco De Rosa, Laura Ridolfi, Angela Riccobon and Massimo Guidoboni. Unit of Immunotherapy and Somatic Cell Therapy, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Meldola, Italy. Doi: 10.1016/j.jcyt.2018.04.002.
285. Poxviral vaccines. The present application relates to improved poxviral vaccines comprising nucleic acid constructs encoding antigenic proteins and invariant chains and novel administration regimens for such poxviral vectors. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed. United States Patent Application 20180125968 A1. Inventors: Stefano Colloca, Riccardo Cortese, Antonella Folgori and Alfredo Nicosia. Assignee: GlaxoSmithKline Biologicals SA. Publication Date: 2018-05-10.
286. Prostaglandin E2 Stimulates the Expansion of Regulatory Hematopoietic Stem and Progenitor Cells in Type 1 Diabetes. Moufida Ben Nasr, Francesca D’Addio, Amir Mohammad Malvandi, Silvia Faravelli, Eduardo Castillo-Leon, Vera Usuelli, Francesca Rocchio Teresa Letizia, Abdel Basset El Essawy, Emma Assi, Chiara Mameli, Elisa Giani, Maddalena Macedoni, Anna Maestroni, Alice Dassano, Cristian Loretelli, Moira Paroni, Giuseppe Cannalire, Giacomo Biasucci, Marco Sala, Alessandra Biffi, Gian Vincenzo Zuccotti and Paolo Fiorina. Nephrology Division, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States; International Center for T1D, Pediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Science L. Sacco, University of Milan, Milan, Italy; Medicine, Al-Azhar University, Cairo, Egypt; Department of Pediatrics, Buzzi Children Hospital, Milan, Italy; Pediatric Clinical Research Center Fondazione Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Science L. Sacco, University of Milan, Milan, Italy; Department of Pediatrics, Children’s Hospital Buzzi, Milan, Italy; Department of Pediatrics, Diabetes Service Studies, University of Milan, Ospedale dei Bambini Vittore Buzzi, Milan, Italy; Department of Bioscience, University of Milan, Milan, Italy; Department of Pediatrics and Neonatology, Ospedale Guglielmo da Saliceto, Piacenza, Italy; Department of Pediatrics, Tradate Hospital, Tradate, Italy; Gene Therapy Program, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Division of Endocrinology, ASST Sacco Fatebenefratelli-Sacco, Milan, Italy; Doi: 10.3389/fimmu.2018.01387.
287. Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens. Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner and Luigi Naldini. Vita-Salute San Raffaele University, Milan, Italy; Targeted Cancer Gene Therapy Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; San Raffaele Telethon Institute for Gene Therapy, Italy; Division of Immunology, Transplant and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy; CUSSB-University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy; Centre for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milan, Italy; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. Nature Communications, Doi: 10.1038/s41467-018-05315-0.
288. PD-L1 EXPRESSING HEMATOPOIETIC STEM CELLS AND USES. United States Patent Application 20180214487. Publication Date: 08/02/2018. Inventors: Fiorina, Paolo (Boston, MA, US). Assignee: The Children's Medical Center Corporation (Boston, MA, US).
289. Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients. Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli and Roberto Luksch. Department of Experimental Oncology and Molecular Medicine, Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Diagnostic Pathology and Laboratory Medicine, Soft Tissue and Bone Pathology, Histopathology and Pediatric Pathology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Pediatric Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy. BMC Cancer201818:983, Doi: 10.1186/s12885-018-4910-8.
290. CD8+ T Cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in Mice. Svenja Veit, Sylvia Jany, Robert Fux, Gerd Sutter and Asisa Volz. Institute for Infectious Diseases and Zoonoses, LMU Munich, Germany and German Center for Infection Research (DZIF), partner site Munich, Germany. Viruses 2018, 10, 718; doi:10.3390/v10120718.
291. Needle-free delivery of DNA: Targeting of hemagglutinin to MHC class II molecules protects rhesus macaques against H1N1 influenza. Petra Mooij, Gunnveig Groedeland, Gerrit Koopman, Tor Kristian Andersen, Daniella Mortier, Ivonne G.Nieuwenhuis, Ernst Verschoor, Zahra Fagrouch, Willy M.Bogers, Bjarne Bogen. Biomedical Primate Research Centre, Rijswijk, The Netherlands and K.G. Jebsen Centre for Influenza Vaccine Research, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Norway. doi:10.1016/j.vaccine.2018.12.049.
292. Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques. Karin Dijkman, Claudia C. Sombroek, Richard A. W. Vervenne, Sam O. Hofman, Charelle Boot, Edmond J. Remarque, Clemens H. M. Kocken, Tom H. M. Ottenhoff, Ivanela Kondova, Mohammed A. Khayum, Krista G. Haanstra, Michel P. M. Vierboom and Frank A. W. Verreck. Biomedical Primate Research Centre, Rijswijk, the Netherlands and Department of Infectious Diseases, Leiden University Medical Centre, Leiden, the Netherlands. Nature Medicine, 21. January 2019.
293. Poly-specific neoantigen-targeted cancer vaccines delay patient derived tumor growth. Luigi Aurisicchio, Erika Salvatori, Lucia Lione, Silvio Bandini, Matteo Pallocca, Roberta Maggio, Maurizio Fanciulli, Francesca De Nicola, Frauke Goeman, Gennaro Ciliberto, Antonella Conforti, Laura Luberto and Fabio Palombo. Takis S.r.l, Rome, Italy and Vitares, Rome, Italy. Journal of Experimental & Clinical Cancer Research201938:78.
294. Induction of Th2-related immune responses and production of systemic IgA in mice intranasally immunized with Brucella abortus malate dehydrogenase loaded chitosan nanoparticles. Sang Hee Soha, Soojin Shima, Young Bin Ima, Hong-Tae Park, Chong-Su Cho, Han Sang Yoo. Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea and Department of Agricultural Biotechnology & Research Institute for Agriculture & Life Sciences, Seoul National University, Seoul, Republic of Korea. Doi: 10.1016/j.vaccine.2019.02.005.
295. CD8.sup.+ T Cells Specific to Apoptosis-Associated Antigens Predict the Response to Tumor Necrosis Factor Inhibitor Therapy in Rheumatoid Arthritis. Alessandra Citro, Rossana Scrivo, Helene Martini, Carmela Martire, Paolo De Marzio, Anna Rita Vestri. PLoS ONE, vol. 10, no. 6, 2015. Health Reference Center Academic, Accessed 8 Apr. 2019.
296. Pd-l1 expressing hematopoietic stem cells and uses. US Patent Application US20190099450A. Applicant: The Children's Medical Center Corporation, Boston, MA (US). Inventor: Paolo Fiorina, Boston, MA (US). Assignee: The Children's Medical Center Corporation, Boston, MA (US). Publication Date: Apr. 4, 2019.
297. Role of human and porcine MHC DRB1 alleles in determining the intensity of individual human anti-pig T-cell responses. Joachim Hundrieser, Rabea Hein, Claudia Pokoyski, Antje Brinkmann, Heike Düvel, Astrid Dinkel, Britta Trautewig, Janina Franziska Siegert, Dorothee Römermann, Björn Petersen und Reinhard Schwinzer. Transplant Laboratory, Department of General-, Visceral-, and Transplantation Surgery, Hannover Medical School, Hannover, Germany. First published: 09 May 2019. Doi: 10.1111/xeb.12523.
298. Human Leukocyte Antigen Restricted Gamma Delta T Cell Receptors and Methods of Use Thereof. United States Patent Application US20190169260A1 from June 6th 2019. Inventors: Jürgen Herbert, Ernst Kuball, Guido Joris Jan Kierkels and Zsolt Sebestyen. Assignee: Gadeta Bv.
299. Comparison of the immune response to vaccination with pigeon circovirus recombinant capsid protein (PiCV rCP) in pigeons uninfected and subclinically infected with PiCV. Tomasz Stenzel, Daria Dziewulska, Marcin %u015Amia%u0142ek, Bart%u0142omiej Tyka%u0142owski, Joanna Kowalczyk and Andrzej Koncicki. Department of Poultry Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland. Doi: 10.1371/journal.pone.0219175.
300. Novel Method for Identifying DeltaT-Cell (or GammaT-Cell) Receptor Chains or Parts Thereof that Mediate an Anti-Tumour or an Anti-Infective Response. Inventors: Kuball, Jürgen Herbert Ernst (Hilversum, NL); Janssen, Anke (Utrecht, NL); Beringer, Dennis (Utrecht, NL); Fisch, Paul (Freiburg im Breisgau, DE); Villacorta Hidalgo and Jose Alberto (Gundelfingen, DE). Assignee: UMC UTRECHT HOLDING B.V. (Utrecht, NL); Gadeta B.V. (Utrecht, NL); Albert-Ludwigs-Universität Freiburg (Freiburg, DE). United States Patent Application 20190209613, Publication Date: 07/11/2019.
301. INDUCED DENDRITIC CELLS AND USES THEREOF. United States Patent Application 20190247430. Inventors: Stripecke, Renata (Hannover, DE), Salguero-lopez, Gustavo (Hannover, DE), Daenthanasanmak, Anusara (Hannover, DE)and Ganser, Arnold (Hannover, DE). Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER (Hannover, DE). Publication Date: 08/15/2019.
302. Long-term HPV-specific immune response after one versus two and three doses of bivalent HPV vaccination in Dutch girls. HellaPasmans, Tessa M.Schurink-van't Klooster, Marjan J.M.Bogaard, Debbie M.van Rooijen, Hester E.de Melker, Marij J.P.Welters, Sjoerd H.van der Burg, Fiona R.M.van der Klis and Anne-MarieBuisman. Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands. Doi: 10.1016/j.vaccine.2019.09.066.
303. Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion. Alessandro Ascione, Claudia Arenaccio, Alessandra Mallano, Michela Flego, Mara Gellini, Mauro Andreotti, Craig Fenwick, Giuseppe Pantaleo, Stefano Vella and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità (ISS), Rome, Italy and Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland. BMC Biotechnology volume 19, Article number: 67 (2019).
304. Elicitation of Th1/Th2 related responses in mice by chitosan nanoparticles loaded with Brucella abortus malate dehydrogenase, outer membrane proteins 10 and 19. Soojin Shim, Sang Hee Soh, Young BinIm, Hyun-Eui Park, Chong-Su Cho, Suk Kim and Han Sang Yoo. Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, South Korea; Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, South Korea and College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea. Doi: 10.1016/j.ijmm.2019.151362.
305. A Soluble Version of Nipah Virus Glycoprotein G Delivered by Vaccinia Virus MVA Activates Specific CD8 and CD4 T Cells in Mice. Georgia Kalodimou, Svenja Veit, Sylvia Jany, Ulrich Kalinke, Christopher C. Broder, Gerd Sutter and Asisa Volz. Institute for Infectious Diseases and Zoonoses, LMU Munich, 80539 Munich, Germany; German Center for Infection Research (DZIF), partner site Munich, 80539 Munich, Germany; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research Braunschweig and the Hannover Medical School, 30625 Hannover, Germany; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. Viruses 2020, 12(1), 26; Doi: 10.3390/v12010026.
306. Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection.Tania Løve Aaes, Hanne Verschuere, Agnieszka Kaczmarek, Liesbeth Heyndrickx, Bartosz Wiernicki, Iris Delrue, Bram De Craene, Joachim Taminau, Tinneke Delvaeye, Mathieu J. M. Bertrand, Wim Declercq, Geert Berx, Dmitri V. Krysko, Sandy Adjemian and Peter Vandenabeele. Unit of Molecular Signaling and Cell Death, Center for Inflammation Research, Flemish Institute for Biotechnology, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Belgium and Cancer Research Institute Ghent, Belgium. Journal of Immunolgy, January 3, 2020, ji1900072. DOI:10.4049/jimmunol.1900072.
307. HPV-Specific Systemic Antibody Responses and Memory B Cells are Independently Maintained up to 6 Years and in a Vaccine-Specific Manner Following Immunization with Cervarix and Gardasil in Adolescent and Young Adult Women in Vaccination Programs in Italy. Francesco Nicoli, Barbara Mantelli, Eleonora Gallerani, Valentina Telatin, Irene Bonazzi, Peggy Marconi, Riccardo Gavioli, Liliana Gabrielli, Tiziana Lazzarotto, Luisa Barzon , Giorgio Palù and Antonella Caputo. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy; Department of Molecular Medicine, University of Padova, Padova, Italy; Operative Unit of Clinical Microbiology, St Orsola-Malpighi University Hospital, Bologna, Italy; Department of Specialized, Experimental and Diagnostic Medicine, University of Bologna, Bologna, Italy; Vaccines 2020, 8, 26; doi:10.3390/vaccines8010026.
308. Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c+F4/80+ Macrophages through IL-1R8 Regulation. Sistiana Aiello, Manuel Alfredo Podestà, Pamela Y. Rodriguez-Ordonez, Francesca Pezzuto, Nadia Azzollini, Samantha Solini, Camillo Carrara, Marta Todeschini, Federica Casiraghi, Marina Noris, Giuseppe Remuzzi and Ariela Benigni. Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy. Journal of the American Society of Nephrology, January 2020; DOI: 10.1681/ASN.2019080778.
309. Dendritic cells transduced with glioma-expressed antigen 2 recombinant adenovirus induces specific cytotoxic lymphocyte response and anti-tumor effect in mice. Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Guibo Feng, Qijiang Xiong, Ling Yang and Zhao Yang. Department of Orthopedics, Yongchuan Hospital, Chongqing Medical University, Chongqing, China and Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China. Journal of Inflammation, 31 January 2020. DOI: 10.1186/s12950-020-0239-6.
310. Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study. Raluca Cosgarea, Robert Pollmann, Jusra Sharif, Thomas Schmidt, Ronja Stein, Aura Bodea, Thorsten Auschill, Anton Sculean, Rüdiger Eming, Brandon Greene, Michael Hertl and Nicole Arweiler. Department of Periodontology, Philipps-University Marburg, Marburg, Germany; Department of Dermatology und Allergology, Philipps-University Marburg, Marburg, Germany; Institute of Biometry and Statistics, Philipps-University Marburg, Marburg, Germany; Clinic for Prosthodontics, University of Medicine and Pharmacy, Faculty of Dentistry “Iuliu Hatieganu”, Cluj-Napoca, Romania and Periodontal Private Practice, Cluj-Napoca, Romania. Scientific Reports volume 10 (2020), DOI:10.1038/s41598-020-58548-9.
311.The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory. Ola Grimsholm, Eva Piano Mortari, Alexey N. Davydov, Mikhail Shugay, Anna S. Obraztsova, Chiara Bocci, Emiliano Marasco, Valentina Marcellini, Alaitz Aranburu, Chiara Farroni, Domenico Alessandro Silvestris, Cristina Cristofoletti, Ezio Giorda, Marco Scarsella, Simona Cascioli, Sabina Barresi, Vassilios Lougaris, Alessandro Plebani andRita Carsetti. Bambino Gesù Children’s Hospital IRCCS, Rome, Italy; University of Gothenburg, Gothenburg, Sweden; Central European Institute of Technology, Brno, Czech Republic; Chemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia; Skolkovo Institute of Science and Technology, Moscow, Russia; Istituto Dermopatico dell’Immacolata (IDI), IRCCS, Rome, Italy; University of Brescia, Brescia, Italy; University of Tor Vergata, Rome, Italy; Misericordia Hospital Grosseto, Usl Toscana Sud-est, Grosseto, Italy; Sapienza, University of Rome, Rome, Italy. Cell Reports, Volume 30, Issue 9, 3 March 2020. DOI: 10.1016/j.celrep.2020.02.022.
312. PD-L1 EXPRESSING HEMATOPOIETIC STEM CELLS AND USES. United States Patent Application 20200085878. Abstract: Embodiments disclosed here provide engineered modified hematopoietic stem cells (HSCs), artificially prostaglandin E2 (PGE2)-stimulated HSCs, compositions comprising these HSCs, methods of using these modified HSCs for treating autoimmune diseases and disorders and for suppressing the immune system. In particular, the engineered modified HSCs or PGE2-stimulated HSCs express the surface marker, programmed cell death-1 ligand 1 (PD-L1).Inventors: Fiorina, Paolo (Boston, MA, US). Assignee: The Children's Medical Center Corporation (Boston, MA, US). Publication Date: 03/19/2020.
313. In Celiac Disease Patients the In Vivo Challenge with the Diploid Triticum monococcum Elicits a Reduced Immune Response Compared to Hexaploid Wheat. Stefania Picascia, Alessandra Camarca, Monica Malamisura, Roberta Mandile, Martina Galatola, Donatella Cielo, Laura Gazza, Gianfranco Mamone, Salvatore Auricchio, Riccardo Troncone, Luigi Greco, Renata Auricchio and Carmen Gianfrani. Institute of Biochemistry and Cell Biology, National Research Council, Naples, Italy; Institute of Food Sciences, National Research Council, Avellino, Italy; Department of Medical Translational Sciences, Section of Pediatrics, Federico II University of Naples, Italy; CREA Research Centre for Engineering and Agro%u2010Food Processing, Rome, Italy; European Laboratory for the Food Induced Diseases (E.L.F.I.D), Federico II University of Naples, Italy. Molecular Nutrition Food Research, Doi: 10.1002/mnfr.201901032.
314. PD-L1 EXPRESSING HEMATOPOIETIC STEM CELLS AND USES. United States Patent Application 20200129559. Abstract: Embodiments disclosed here provide engineered modified hematopoietic stem cells (HSCs), artificially prostaglandin E2 (PGE2)-stimulated HSCs, compositions comprising these HSCs, methods of using these modified HSCs for treating autoimmune diseases and disorders and for suppressing the immune system. In particular, the engineered modified HSCs or PGE2-stimulated HSCs express the surface marker, programmed cell death-1 ligand 1 (PD-L1). Inventors: Fiorina, Paolo (Boston, MA, US). Assignee: The Children's Medical Center Corporation (Boston, MA, US). Application Number: 16/673283. Publication Date: 04/30/2020.
315. Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques. Michel P. M. Vierboom, Agnes L. Chenine, Patricia A. Darrah, Richard A. W. Vervenne, Charelle Boot, Sam O. Hofman, Claudia C. Sombroek, Karin Dijkman, Mohamed A. Khayum, Marieke A. Stammes, Krista G. Haanstra, Chantal Hoffmann, Doris Schmitt, Nathalie Silvestre, Alexander G. White, H. Jacob Borish, Robert A. Seder, Nadia Ouaked, Stephane Leung-Theung-Long, Geneviève Inchauspé, Ravi Anantha, Mary Limbach, Thomas G. Evans, Danilo Casimiro, Maria Lempicki, Dominick J. Laddy, Aurelio Bonavia and Frank A. W. Verreck. Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands; Aeras, Rockville, MD, USA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Infectious Diseases Department, Transgene SA, ABL Europe Building, Lyon, France; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; International AIDS Vaccine Initiative, New York, NY, USA; GSK, Rixensart, Belgium. npj Vaccines volume 5, Article number: 39 (2020).
316. Poxviral Vaccines. United States Patent Application Publication 20200164061A1. Abstract: The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed. Applicant: GlaxoSmithKline Biologicals SA. Inventor: Stefano Colloca, Riccardo Cortese, Antonella Folgori and Alfredo Nicosia. Assignee: GlaxoSmithKline Biologicals SA. Publication Date: 05/28/2020.
317. IFNγ production profile in turkeys of different immunological status after TRTvaccination. Marcin Smialek, Bartlomiej Tyklalowski, Daria Dziewulska, Joanna Kowalczyk and Andrzej Koncicki. Department of Poultry Diseases, Faculty of Veterenary Medicine, University of Warmia and Mazury, Olsztny, Poland. Journal of Veterinary Research, DOI 10.2478/jvetres-2020-0040.
318. GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR. Trudy Straetemans, Guido J. J. Kierkels, Ruud Doorn, Koen Jansen, Sabine Heijhuurs, Joao M. dos Santos, Anna D. D. van Muyden, Henri Vie, Béatrice Clemenceau, Reinier Raymakers, Moniek de Witte, Zsolt Sebestyén and Jürgen Kuball. Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Netherlands; Department of Hematology, University Medical Center Utrecht, Netherlands; CRCINA, INSERM 1232, CNRS, Université d’Angers, Université de Nantes, France and CHU de Nantes, Hôtel Dieu, UTCG, Nantes, France. Frontiers in Immunology, 30 May 2018, Doi: 10.3389/fimmu.2018.01062.
319. NUCLEOTIDE SEQUENCE EXPRESSING AN EXOSOME-ANCHORING PROTEIN FOR USE AS VACCINE. United States Patent Application 20200206329. Abstract: The present invention concerns a nucleotide sequence expressing a fusion protein, said fusion protein comprising or consisting of an exosome-anchoring protein fused at its C-terminus with an antigen, or a DNA expression vector comprising said nucleotide sequence, for use as vaccine. Inventors: Federico, Maurizio Paolo Maria (Roma, IT). Assignee: ISTITUTO SUPERIORE DI SANITA' (Roma, IT). Publication Date: 07/02/2020.
320. Nicotinamide inhibits melanoma in vitro and in vivo. Francesca Scatozza, Federica Moschella, Daniela D’Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano and Antonio Facchiano. IDI-IRCCS, Istituto Dermopatico dell’Immacolata, Rome, Italy; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy and Unit of Human Anatomy, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, Rome, Italy. Journal of Experimental & Clinical Cancer Research volume 39, Article number: 211 (2020).
321. Human cell-based in vitro systems for vaccine evaluation. Tapia Calle, María Gabriela. University of Groningen. DOI:10.33612/diss.100812074.
322. COMPOSITIONS AND METHODS FOR CELL TARGETING THERAPIES. United States Patent Application 20200368278. Abstract: Described herein are compositions and methods of treatment for identifying and clearing cell types expressing particular cell surface markers. In one embodiment, the composition comprises a polypeptide construct that selectively binds a J-configuration of CD277 on a target cell, wherein said polypeptide construct is expressed in an engineered cell. Inventors: Kuball, Jürgen Herbert Ernst (Utrecht, NL); Sebestyen, Zsolt (Utrecht, NL); Beringer, Dennis (Utrecht, NL) and Vyborova, Anna (Utrecht, NL). Assignee: UMC UTRECHT HOLDING B.V. (Utrecht, NL). Publication Date: 11/26/2020.
323. Immunogenicity and efficacy of the COVID-1 19 candidate vector 2 vaccine MVA SARS 2 S in preclinical vaccination. Alina Tscherne, Jan Hendrik Schwarz, Cornelius Rohde, Alexandra Kupke, Georgia Kalodimou, Leonard Limpinsel, Nisreen M.A. Okba, Berislav Bo%u0161njak, Inga Sandrock, Sandro Halwe, Lucie Sauerhering, Katrin Brosinski, Nan Liangliang, Elke Duell, Sylvia Jany, Astrid Freudenstein, Jörg Schmidt, Anke Werner, Michelle Gellhorn Sera, Michael Klüver, Wolfgang Guggemos, Michael Seilmaier, Clemens-Martin Wendtner, Reinhold Förster, Bart L. Haagmans, Stephan Becker, Gerd Sutter, Asisa Volz. Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany; Institute of Virology, Philipps University Marburg, Marburg, Germany; German Center for Infection Research, Munich, Germany; German Center for Infection Research, Gießen-Marburg-Langen, Germany; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands; Institute of Immunology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Hannover, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany; Munich Clinic Schwabing, Academic Teaching Hospital, LMU Munich, Munich, Germany; Institute of Virology, University of Veterinary Medicine Hannover, Germany. Doi: 10.1101/2021.01.09.426032.
324. Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination. Michel P.M.Vierboom, KarinDijkman, Claudia C.Sombroek, Sam O.Hofman, Charelle Boot, Richard A.W. Vervenne, Krista G.Haanstra, Maartenvan der Sande, Liesbeth van Emst, JorgeDomínguez-Andrés, Simone J.C.F.M. Moorlag, Clemens H.M. Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H.A. Martens, Reinout van Crevel, Mihai G.Netea %u2026 Frank A.W. Verreck. Biomedical Primate Research Centre, Rijswijk, the Netherlands; Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands; Radboud University Medical Centre, Nijmegen, the Netherlands; TuBerculosis Vaccine Initiative, Lelystad, the Netherlands and Biofabri, Pontevedra, Spain. Cell Reports Medicine, Volume 2, Issue 1, 19 January 2021, 100185.
325. Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection. Karin Dijkman, Nacho Aguilo, Charelle Boot, Sam O. Hofman, Claudia C. Sombroek, Richard A.W. Vervenne, Clemens H.M. Kocken, Dessislava Marinova, Jelle Thole, Esteban Rodríguez, Michel P.M. Vierboom, Krista G. Haanstra, Eugenia Puentes, Carlos Martin and Frank A.W. Verreck. Biomedical Primate Research Centre (BPRC), Rijswijk, the Netherlands; Department of Microbiology, Faculty of Medicine, IIS Aragon, University of Zaragoza, Zaragoza, Spain; CIBERES, Instituto de Salud Carlos III, Madrid, Spain; TuBerculosis Vaccine Initiative (TBVI), Lelystad, the Netherlands and Biofabri, Pontevedra, Spain. Cell Reports Medicine, Volume 2, Issue 1, 19 January 2021, 100187.
326. A broad spectrum HVT-H5 avian influenza vector vaccine which induces a rapid onset of immunity. Sylvia Reemers, Iwan Verstegen, Stephanie Basten, Willem Hubers and Saskia van de Zande. MSD Animal Health, Boxmeer, the Netherlands. Doi: 10.1016/j.vaccine.2021.01.018.
327. CD8+ T cell immunogenicity induced by endogenous EVs engineered by antigens fused to a truncated Nefmut EV-anchoring protein. Chiara Chiozzini, Francesco Manfredi, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Eleonora Olivetta, and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy and National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy. bioRxiv preprint, Doi: 0.1101/2021.02.05.429891.
328. Long-term antitumor CD8+ T cell immunity induced by endogenously engineered extracellular vesicles. Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Eleonora Olivetta, Andrea Giovannelli, Patrizia Leone and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy and National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy. bioRxiv preprint, Doi: 10.1101/2021.02.05.429897.
329. Integrase-Defective Lentiviral Vector Is an Efficient Vaccine Platform for Cancer Immunotherapy. Valeria Morante, Martina Borghi, Iole Farina, Zuleika Michelini, Felicia Grasso, Alessandra Gallinaro, Serena Cecchetti, Antonio Di Virgilio, Andrea Canitano, Maria Franca Pirillo, Roberta Bona, Andrea Cara and Donatella Negri. Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy; National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy; Confocal Microscopy Unit NMR, Confocal Microscopy Area Core Facilities, Istituto Superiore di Sanità, Rome, Italy. Viruses 2021, Feb 23, 13:355. doi: 10.3390/v13020355
330. Simultaneous CD8+ T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs. Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Andrea Giovannelli, Patrizia Leone and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy and National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy. Vaccines 2021, 9(3), 240; Doi: 10.3390/vaccines9030240.
330. Simultaneous CD8+ T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs. Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Andrea Giovannelli, Patrizia Leone and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy and National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy. Vaccines 2021, 9(3), 240; Doi: 10.3390/vaccines9030240.
331. Autoreactive Peripheral Blood THelper Cell Responses in BullousPemphigoid and Elderly Patients WithPruritic Disorders. Dario Didona, Luca Scarsella, Milad Fehresti, Farzan Solimani, Hazem A. Juratli, Manuel Göbel, Stefan Mühlenbein, Lily Holiangu, Josquin Pieper, Vera Korff, Thomas Schmidt, Cassian Sitaru, Rüdiger Eming, Michael Hertl and Robert Pollmann. Department of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany; Department of Dermatology, Venereology and Allergology, Charite %u0301Universitätsmedizin Berlin, Berlin, Germany and Department of Dermatology and Allergology, Universität Freiburg, Freiburg, Germany. Frontiers in Immunology, 25 March 2021, Doi: 10.3389/fimmu.2021.569287.
332. The C-Terminal Domain of Nefmut Is Dispensable for the CD8+ T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles. Chiara Chiozzini, Francesco Manfredi, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Eleonora Olivetta and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy and National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy.
Vaccines 2021, 9(4), 373; doi: 10.3390/vaccines9040373.
333. T%u2010cell mediated responses against alpha%u2010foetoprotein in hepatocellular carcinoma: Relationship with hepatitis C virus infection, tumour phenotype and patients’ survival. David J. Pinato, Petros Fessas, Antonello Gibbin, Giuseppa Occhino, Elisa Boccato, Carlo Smirne, Rosalba Minisini and Mario Pirisi. Division of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK; Department of Translational Medicine, Università degli Studi del Piemonte Orientale “A. Avogadro”, Novara, Italy and Interdisciplinary Research Center of Autoimmune Diseases, Università degli Studi del Piemonte Orientale “A. Avogadro”, Novara, Italy. Live Cancer Intrernational, Doi: 10.1002/lci2.22.
334. Erythropoietin enhancesimmunostimulatory properties ofimmature dendritic cells. F. Rocchetta, S. Solini, M. Mister, C. Mele,P. Cassis, M. Noris,G. Remuzzi and S. Aiello. Transplant Research Center "Chiara Cucchi de Alessandri e Gilberto Crespi", Mario NegriInstitute for Pharmacological Research, and Department of Immunology and OrganTransplantation, Ospedali Riuniti – Mario NegriInstitute for Pharmacological Research, Bergamo, Italy.
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335. Einfluss von Fumarsäureestern auf T-Zellsubpopulationen bei Patienten mit Psoriasis. Inaugural-Dissertation zur Erlangung des Doktorgrades der gesamten Humanmedizin dem Fachbereich Medizin der Philipps-Universität Marburg vorgelegt von Stella Riemann aus Lübeck. Marburg, 2021.
336. Patient risk stratification and tailored clinical management of post-transplant CMV-, EBV-, and BKV-infections by monitoring virus-specific T-cell immunity. Anastasia Papadopoulou, Kiriakos Koukoulias, Maria Alvanou, Vassilios K.Papadopoulos, Zoe Bousiou, Vasiliki Kalaitzidou, Fotini S.Kika, Apostolia Papalexandri, Despina Mallouri, Ioannis Batsis, Ioanna Sakellari, Achilles Anagnostopoulos and Evangelia Yannaki. Hematology Department-Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, “GeorgePapanikolaou” Hospital,Thessaloniki,Greece; Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki,Greece; Blood Bank Department, General Hospital of Pella-Giannitsa, Giannitsa, Greece; Department of Medicine, University of Washington, Seattle, Washington, USA. DOI: 10.1002/jha2.175.
337. Activation of interferon regulatory factor 3 by replication-competent Vaccinia virusesimproves antitumor efficacy mediated by T-cell responses. Stephanie Riederer, Robert Fux, Michael H. Lehmann, Asisa Volz, Gerd Sutter and JuanJ. Rojas. Division of Virology, Department of Veterinary Sciences, LMU Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany; Department of Pathology and Experimental Therapies, IDIBELL, University of Barcelona, L'Hospitalet de Llobregat, Spain. Molecular Therapy Oncolytics, Doi: 10.1016/j.omto.2021.06.001
338. Human desmocollin 3-specific IgG antibodies are pathogenic in a humanized HLA-class II transgenic mouse model of pemphigus. C. Hudemann, R. Maglie, M. Llamazares, B. Beckert, D. Didona, R. Tikkanen, T. Schmitt, T. Hashimoto, J.Waschke, M. Hertl and R. Eming. Department of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany; Section of Dermatology, Department of Health Sciences, University of Florence, Italy; Institute of Biochemistry, Medical Faculty, University of Giessen, Giessen, Germany; Institute of Anatomy and Cell Biology, Ludwig-Maximilians-Universität München, München, Germany; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan; Klinik III Dermatologie, Venerologie & Allergologie, Bundeswehrzentralkrankenhaus Koblenz, Koblenz, Germany and Cancer Epigenomics Division, German Cancer Research Center (DKFZ), Heidelberg, Germany. Journal of Investigative Dermatology.
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339. Bacterium-like particles as multi-epitope delivery platform for Vlasmodium berghei circumsporozoite protein induce complete protection against malaria in mice. Krystelle Nganou-Makamdop, Maarten L. van Roosmalen, Sandrine A.L. Audouy, Geert-Jan van Gemert, Kees Leenhouts, Cornelus C. Hermsen and Robert W Sauerwein. Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Mucosis BY Groningen, The Netherlands; BiOMaDe Technology Foundation, Groningen, The Netherlands.
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340. Safety and Efficiency Modifications of Simian Immunodeficiency Virus-Based Integrase Defective Lentiviral Vectors for Immunization. Roberta Bona, Zuleika Michelini, Chiara Mazzei, Alessandra Gallinaro, Andrea Canitano, Martina Borghi, Maria Fenicia Vescio, Antonio Di Virgilio, Maria Franca Pirillo, Mary E. Klotman, Donatella Negri and , Andrea Cara. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy; Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy; Center for Animal Research and Welfare, Istituto Superiore di Sanità, Rome, Italy; Department of Medicine, Duke University School of Medicine, Durham, NC, USA. DOI: 10.1016/j.omtm.2021.09.01.
341. Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA. Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni and Vincenzo Camisa. Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; Occupational Medicine/Health Technology Assessment and Safety Research Unit, Clinical-Technological Innovations Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; Health Directorate, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy; Takis s.r.l., Rome, Italy; Section of Occupational Medicine and Labor Law, Post-Graduate School of Occupational Health, University Cattolica del Sacro Cuore, Rome, Italy; Department of Woman, Child & Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. DOI: 10.3390/cells10102541.
342. Vaccinated and Convalescent Donor–Derived Severe Acute Respiratory Syndrome Coronavirus 2–Specific T Cells as Adoptive Immunotherapy for High-Risk Coronavirus Disease 2019 Patients. Penelope-Georgia Papayanni, Dimitrios Chasiotis, Kiriakos Koukoulias, Aphrodite Georgakopoulou, Anastasia Iatrou, Eleni Gavriilaki, Chrysavgi Giannaki, Militsa Bitzani, Eleni Geka, Polychronis Tasioudis, Diamantis Chloros, Asimina Fylaktou, Ioannis Kioumis, Maria Triantafyllidou, Sotiria Dimou-Besikli, Georgios Karavalakis, Afroditi K Boutou, Eleni Siotou, Achilles Anagnostopoulos, Anastasia Papadopoulou and Evangelia Yannaki. Hematology Department-Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, George Papanikolaou Hospital, Thessaloniki, Greece; Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; A’ Intensive Care Unit, George Papanikolaou Hospital, Thessaloniki, Greece; Intensive Care Unit, AHEPA University Hospital, Thessaloniki, Greece; Department of Respiratory Medicine, George Papanikolaou Hospital, Thessaloniki, Greece; National Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital, Thessaloniki, Greece; Respiratory Failure Department, George Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Medicine, University of Washington, Seattle, Washington, USA. DOI: 10.1093/cid/iab371.
343. CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis. Neda Feizi, Chiara Focaccetti, Ilenia Pacella, Gloria Tucci, Alessandra Rossi, Massimo Costanza, Rosetta Pedotti, John Sidney, Alessandro Sette, Claudia La Rocca, Claudio Procaccini, Giuseppe Matarese, Vincenzo Barnaba and Silvia Piconese. Department of Human Science and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy; Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy; Molecular Neuro-Oncology Unit, Department of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA; Laboratorio di Immunologia, Istituto per l’Endocrinologia e l’Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Naples, Italy; Unità di Neuroimmunologia, IRCCS Fondazione Santa Lucia, Rome, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli “Federico II”, Naples, Italy; Laboratory affiliated to Istituto Pasteur Italia – Fondazione Cenci Bolognetti, Rome, Italy. Cell Death & Disease volume 12, Article number: 1026 (2021)
344. Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice. Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Patrizia Leone, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Massimo Sanchez, Andrea Cara, Zuleika Michelini and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy; National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy; 3Core Facilities, Istituto Superiore di Sanità, Rome, Italy. bioRxiv preprint, Doi: 10.1101/2022.01.10.475620.
345. Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group. Alejandro Escobar, Felipe E. Reyes-López, Mónica L. Acevedo, Luis Alonso-Palomares, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Hugo Portillo, Jimena Gatica, Ivan Flores, Estefanía Nova-Lamperti, Carlos Barrera-Avalos, María Rosa Bono, Leonardo Vargas, Valeska Simon, Elias Leiva-Salcedo, Cecilia Vial, Juan Hormazabal, Lina Jimena Cortes, Daniel Valdés, Ana M. Sandino, Mónica Imarai and Claudio Acuña-Castillo. Laboratorio Biología Celular y Molecular, Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago, Chile; Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain; Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Providencia, Chile; Laboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile; Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile; Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile and Programa Hantavirus y Zoonosis, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, Chile. Front. Immunol., 31 January 2022; Doi: 10.3389/fimmu.2021.766278.
346. Neoantigen cancer vaccine augments anti-CTLA-4 efficacy. Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Antonella Conforti, Gennaro Ciliberto, Luigi Aurisicchio and Fabio Palombo. Takis, Rome, Italy; Neomatrix, Rome, Italy; Evvivax, Rome, Italy; Scientific Directorate, IRCCS Regina Elena National Cancer Institute, Rome, Italy. npj Vaccines volume 7, Article number: 15 (2022).
347. Adding Help to an HLA-A*24:02 Tumor-Reactive γδTCR Increases Tumor Control. Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Wouter Scheper, Laura Bongiovanni, Alain de Bruin, Dennis X. Beringer, Rimke Oostvogels, Trudy Straetemans, Zsolt Sebestyen and Jürgen Kuball. Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands; Department of Biomolecular Health Sciences, Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands and Department of Hematology, University Medical Center Utrecht, Utrecht, Netherlands. Front. Immunol., 25 October 2021, Doi: 10.3389/fimmu.2021.752699.
348. Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection. Anna C Ramírez-Suárez, Taimi Paneque-Guerrero, Dionne Casillas-Casanova, Karelia Cosme, Dania Bacardí, Carlos A Duarte, Julio Ancízar, Emma Brown, Jorge Castro, José Suárez-Alba, Hilda Garay, Karla Pereira, Celia Fernández-Ortega. Pharmaceutical Department, Center for Genetic Engineering and Biotechnology, Habana, Cuba; Preclinical Research Direction, Center for Genetic Engineering and Biotechnology, Habana, Cuba and Chemical and Physical Department, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba. Human and Experimental Toxicology (HET), Doi: 10.1177/09603271211073708.
349. Linear DNA amplicons as a novel cancer vaccine strategy. Antonella Conforti, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Clay Shorrock, James A. Hayward, Yuhua Sun, Ben Minghwa Liang4 Fabio Palombo, Brian Viscount and Luigi Aurisicchio. Takis Biotech, Rome, Italy; Evvivax Biotech, Rome, Italy; Neomatrix Biotech, Rome, Italy; Applied DNA Sciences, New York, USA. bioRxiv preprint, Doi: 10.1101/2022.02.09.479777.
350. Effects of the age of vaccination on the humoral responses to a human papillomavirus vaccine. Francesco Nicoli, Barbara Mantelli, Eleonora Gallerani, Valentina Telatin, Laura Squarzon, Serena Masiero, Riccardo Gavioli, Giorgio Palù, Luisa Barzon and Antonella Caputo. Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Italy and Department of Molecular Medicine, University of Padova, Italy. npj Vaccines 7, 37 (2022). Doi: 10.1038/s41541-022-00458-0.
351. Protective CD8+ T Cell Response Induced by Modified Vaccinia Virus Ankara Delivering Ebola Virus Nucleoprotein. Alexandra Kupke, Asisa Volz, Erik Dietzel, Astrid Freudenstein, Jörg Schmidt, Hosam Shams-Eldin, Sylvia Jany, Lucie Sauerhering, Verena Krähling, Michelle Gellhorn Serra, Christiane Herden, Markus Eickmann, Stephan Becker and Gerd Sutter. Institute of Virology, Philipps University Marburg, 35043 Marburg, Germany; German Center for Infection Research, Partner Site Giessen-Marburg-Langen, 35043 Marburg, Germany; Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany; German Center for Infection Research, Partner Site Munich, 80539 Munich, Germany; Division of Virology, Institute for Infectious Diseases and Zoonoses, LMU Munich, 80539 Munich, Germany and Institute of Veterinary Pathology, Justus Liebig University Giessen, 35392 Giessen, Germany. Vaccines 2022, 10(4), 533; Doi: 10.3390/vaccines10040533.
352. Neutralizing antibody and T cell responses to SARS-CoV-2 vaccination in hematopoietic cell transplant recipients. Eleni Gavriilaki, Anastasia Papadopoulou, Tasoula Touloumenidou, Fani Stavridou, Evaggelia-Evdoxia Koravou, Maria Giannaki, Apostolia Papalexandri, Georgios Karavalakis, Ioannis Batsis, Andreas Kourelis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Damianos Sotiropoulos, Evangelia Yannaki, Ioanna Sakellari and Achilles Anagnostopoulos. Hematology Department – Hematopoietic Cell Transplant (HCT) Unit – Gene and Cell Therapy Center, George Papanikolaou Hospital, Thessaloniki, Greece; Microbiology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece. Bone Marrow Transplantation 2022, Doi: 10.1038/s41409-022-01675-w.
353. Identification of a tumor-specific allo-HLA–restricted γδTCR. G. J. J. Kierkels, W. Scheper, A. D. Meringa, I. Johanna, D. X. Beringer, A. Janssen, M. Schiffler, T. Aarts-Riemens, L. Kramer, T. Straetemans, S. Heijhuurs, J. H. W. Leusen, E. San José, K. Fuchs, M. Griffioen, J. H. Falkenburg, L. Bongiovanni, A. de Bruin, D. Vargas-Diaz, M. Altelaar, A. J. R. Heck, L. D. Shultz, F. Ishikawa, M. I. Nishimura, Z. Sebestyén and J. Kuball.Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Facultad de Ciencias Biomédicas y Salud, Universidad Europea, Madrid, Spain; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands; Department of Pathobiology, Faculty of Veterinary Medicine, Dutch Molecular Pathology Center, Utrecht University, Utrecht, The Netherlands; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research; Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands. Department of Immunology, The Jackson Laboratory, Bar Harbor, ME, USA; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA; Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands. Blood Adv (2019) 3 (19): 2870–2882. DOI: 10.1182/bloodadvances.2019032409.
354. Robust SARS-COV-2-specific T-cell immune memory persists long-term in immunocompetent individuals post BNT162b2 double shot. Anastasia Papadopoulou, Fani Stavridou, Maria Giannaki, Kiriaki Paschoudi, Fani Chatzopoulou, Eleni Gavriilaki, Grigorios Georgolopoulos, Achilles Anagnostopoulos, Evangelia Yannaki. Hematology Department- Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, “George Papanikolaou” Hospital, Thessaloniki, Greece; Microbiology Department, Aristotle University of Thessaloniki, Greece. Heliyon Volume 8, Issue 7, July 2022, e09863; Doi: 10.1016/j.heliyon.2022.e09863.
355. DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model. Mirco Compagnone, Eleonora Pinto, Erika Salvatori, Lucia Lione, Antonella Conforti, Silvia Marchese, Micol Ravà, Kathryn Ryan, Yper Hall, Emma Rayner, Francisco J. Salguero, Jemma Paterson, Matteo Iannacone, Raffaele De Francesco, Luigi Aurisicchio and Fabio Palombo. Neomatrix, Rome, Italy; Takis, Rome, Italy; Evvivax, Rome, Italy; INGM-Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy; UK Health Security Agency (UKHSA), Porton Down, Salisbury, UK; Vita-Salute San Raffaele University, Milan, Italy; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Italy. Vaccines 2022, 10, 1178. Doi: 10.3390/vaccines10081178.
356. Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets. Selina Khan, Nadine C. Salisch, Ana Izquierdo Gil, Satish Boedhoe, Karin Feddes-de Boer, Jan Serroyen, Hanneke Schuitemaker and Roland C. Zahn. Janssen Vaccines & Prevention, Leiden, The Netherlands. Vaccines volume 7, Article number: 146 (2022); Doi: 10.1038/s41541-022-00567.
357. Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2. Davide Proietto, Beatrice Dallan, Eleonora Gallerani, Valentina Albanese, Sian Llewellyn-Lacey, David A. Price, Victor Appay, Salvatore Pacifico, Antonella Caputo, Francesco Nicoli and Riccardo Gavioli. Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy; Department of Environment and Prevention Sciences, University of Ferrara, 44123 Ferrara, Italy; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK; Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK; Université de Bordeaux, Bordeaux, France. Vaccines 2023, 11(1), 154; Doi: 10.3390/vaccines11010154.
358. Effects of Sirolimus treatment on patients with β-Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells. Matteo Zurlo, Francesco Nicoli, Davide Proietto, Beatrice Dallan, Cristina Zuccato, Lucia Carmela Cosenza, Jessica Gasparello, Chiara Papi, Elisabetta d'Aversa, Monica Borgatti, Chiara Scapoli, Alessia Finotti and Roberto Gambari. Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy; Department of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy. Department of Life Sciences and Biotechnology, Section of Biology and Evolution, University of Ferrara, Ferrara, Italy; Center Chiara Gemmo and Elio Zago for the Research on Thalassemia, University of Ferrara, Ferrara, Italy. DOI: 10.1111/jcmm.17655.
359. Induction of SARS-CoV-2 N-specific CD8 + T cell immunity in lungs by engineered extracellular vesicles associates with strongly impaired viral replication. Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy; National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy.
Doi: 10.1101/2023.01.19.524762.
360. IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity. Anastasia Geladaris, Silke Häusser-Kinzel, Roxanne Pretzsch, Nitzan Nissimov, Klaus Lehmann-Horn, Darius Häusler and Martin S. Weber. Institute of Neuropathology, University Medical Centre Göttingen, Göttingen, Germany; Fraunhofer-Institute for Translational Medicine and Pharmacology ITMP, Göttingen, Germany; Department of Neurology, University Medical Centre Göttingen, Göttingen, Germany; Department of Neurosurgery, Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Neurology, School of Medicine, Technical University of Munich, Munich, Germany. Acta Neuropathologica, Doi: 10.1007/s00401-023-02552-6.
361. Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms. Federico D’Alessio, Lucia Lione, Erika Salvatori, Federica Bucci, Alessia Muzi, Giuseppe Roscilli, Mirco Compagnone, Eleonora Pinto, Gianfranco Battistuzzi, Antonella Conforti, Luigi Aurisicchio and Fabio Palombo. Takis, Rome, Italy; Neomatrix, Rome, Italy; Alfasigma, Pomezia, Italy; Evvivax, Rome, Italy. Vaccines 2023, 11(3), 678; Doi: 10.3390/vaccines11030678.
362. Adenoviral penton and hexon proteins are equivalent immunogenic targets of virus-specific T cells after HSCT in children. Astrid Wintering, Sabine Tischer-Zimmermann, Rebecca Schultze-Florey, Rita Beuer, Martin Sauer, Rainer Blasczyk, Albert Heim, Britta Eiz-Vesper and Britta Maecker-Kolhoff. Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; Institute for Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover Germany; Institute of Virology, Hannover Medical School, Hannover, Germany and German Center for Infection Research (DZIF). Published: March 17, 2023 DOI: 10.1016/j.jtct.2023.03.013.
363. A protective measles virus-derived vaccine inducing long-lasting immune responses against influenza A virus H7N9. Cindy Hörner, Anna H. Fiedler, Bianca S. Bodmer, Lisa Walz, Vivian A. Scheuplein, Stefan Hutzler, Mikhail N. Matrosovich, Veronika von Messling and Michael D. Mühlebach. Paul-Ehrlich-Institut, Langen, Germany; German Center for Infection Research, Gießen-Marburg-Langen, Germany; Institute of Molecular Virology and Cell Biology, Greifswald-Insel Riems, Germany; Institute of Virology, Philipps University, Marburg, Germany. npj Vaccines volume 8, Article number: 46 (2023).
364. Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease. Stephanie Riederer, Ana del Canizo, Javier Navas, Marlowe G. Peter, Ellen K. Link, Gerd Sutter and Juan J. Rojas. Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany; Immunology Unit, Department of Pathology and Experimental Therapies, School of Medicine, University of Barcelona—UB, Barcelona, Spain; Immunity, Inflammation, and Cancer Group, Oncobell Program, Institut d’Investigació Biomèdica de Bellvitge—IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. Cancer Gene Therapy (2023), DOI: 10.1038/s41417-023-00610-5.
365. Characterization of recombinant Modified Vaccinia virus Ankara delivering African swine fever virus proteins. Inaugural-Dissertation zur Erlangung der Doktorwürde der Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München von Lia Erlbeck geb. Sattlegger. Aus dem Veterinärwissenschaftlichen Department der Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München, Lehrstuhl für Virologie. Arbeit angefertigt unter der Leitung von Univ.-Prof. Dr. Dr. h. c. Gerd Sutter. Mitbetreuung durch Dr. med. vet. Robert Fux. Februar 2023.
366. IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity. Anastasia Geladaris, Silke Häusser-Kinzel, Roxanne Pretzsch, Nitzan Nissimov, Klaus Lehmann-Horn Darius Häusler und Martin S. Weber. Institute of Neuropathology, University Medical Center Göttingen, Germany; Fraunhofer-Institute for Translational Medicine and Pharmacology, Göttingen, Germany; Department of Neurology, University Medical Center Göttingen, Germany; Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Germany; Department of Neurology, School of Medicine, Technical University of Munich, Germany. Acta Neuropathol 145, 01 March 2023, 461–477; Doi: 10.1007/s00401-023-02552-6.
367. Short- and Long-Interval Prime-Boost Vaccination with the Candidate Vaccines MVA-SARS-2-ST and MVA-SARS-2-S Induces Comparable Humoral and Cell-Mediated Immunity in Mice. Georgia Kalodimou, Sylvia Jany, Astrid Freudenstein, Jan Hendrik Schwarz, Leonard Limpinsel, Cornelius Rohde, Alexandra Kupke, Stephan Becker, Asisa Volz, Alina Tscherne and Gerd Sutter. Division of Virology, Department of Veterinary Sciences, LMU Munich, Oberschleißheim, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Oberschleißheim, Germany; Institute of Virology, Philipps University of Marburg, Marburg, Germany; German Center for Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Marburg, Germany; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany. Viruses 2023, 15(5), 1180; Doi: 10.3390/v15051180.
368. The induction of SARS-CoV-2-specific CD8+ T cell immunity uncouples with the viral spread in K18-hACE2 infected mice. Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy; National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy. DOI: 10.21203/rs.3.rs-2950996/v1.
369. Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles. Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy. npj Vaccines volume 8, Article number: 83 (2023). DOI: 10.1038/s41541-023-00686-y.
370. Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice. Martin C. Langenmayer, Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, Gerd Sutter and Asisa Volz. Institute for Infectious Diseases and Zoonoses, LMU Munich, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany; Institute of Clinical Hygiene, Medical Microbiology and Infectiology, Paracelsus Medical University, Klinikum Nürnberg, Nuremberg, Germany; Immunology Unit, Department of Pathology and Experimental Therapies, Faculty of Medicine and Health Sciences, University of Barcelona—Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Research Unit Analytical Pathology, Helmholtz Zentrum Munich, Neuherberg, Germany; Institute for Veterinary Pathology, LMU Munich, Munich, Germany; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany; German Center of Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany. Pathogens 2023, 12(7), 867; Doi: 10.3390/pathogens1207086.
371. Targeting Subtype-Independent Immune Responses Against Influenza A Virus. Inaugural-Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften von Kevin Wittwer. Aus dem Institut für Virologie, Geschäftsführender Direktor Prof. Dr. Stephan Becker, des Fachbereichs Medizin der Philipps-Universität Marburg in Zusammenarbeit mit dem Paul-Ehrlich-Institut, deutsches Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel. Marburg, 2022.
372. Age differentially affects the maintenance of adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19. Francesco Nicoli, Beatrice Dallan, Davide Proietto, Martina De Laurentis, Eleonora Gallerani, Mara Martino, Sara Ghisellini, Amedeo Zurlo, Stefano Volpato, Benedetta Govoni, Michela Borghesi, Valentina Albanese, Victor Appay, Stefano Bonnini, Sian Llewellyn-Lacey, Salvatore Pacico, David Price, Antonella Caputo and Riccardo Gavioli. University of Ferrara; St. Anna Hospital, Ferrara; Cardiff University; Immuconcept CNRS UMR 5164. Research Square July 2023, Doi: 10.21203/rs.3.rs-3101473/v1.
373. SARS-CoV-2-specific T cell therapy for severe COVID-19: a randomized phase 1/2 trial. Anastasia Papadopoulou, George Karavalakis, Efthymia Papadopoulou, Aliki Xochelli, Zoi Bousiou, Anastasios Vogiatzoglou, Penelope-Georgia Papayanni, Aphrodite Georgakopoulou, Maria Giannaki, Fani Stavridou, Ioanna Vallianou, Maria Kammenou, Evangelia Varsamoudi, Vasiliki Papadimitriou, Chrysavgi Giannaki, Maria Sileli, Zoi Stergiouda, Garyfallia Stefanou, Georgia Kourlaba, George Gounelas, Maria Triantafyllidou, Eleni Siotou, Antonia Karaglani, Eleni Zotou, Georgia Chatzika, Anna Boukla, Apostolia Papalexandri, Maria-Georgia Koutra, Dimitra Apostolou, Georgia Pitsiou, Petros Morfesis, Michalis Doumas, Theodoros Κarampatakis, Nikolaos Kapravelos, Militsa Bitzani, Maria Theodorakopoulou, Eva Serasli, Grigorios Georgolopoulos, Ioanna Sakellari, Asimina Fylaktou, Stavros Tryfon, Achilles Anagnostopoulos and Evangelia Yannaki. Hematopoietic Cell Transplantation Unit, Department of Hematology Gene and Cell Therapy Center, George Papanikolaou Hospital, Thessaloniki, Greece; Department of Respiratory Medicine, George Papanikolaou Hospital, Thessaloniki, Greece; Department of Immunology, National Peripheral Histocompatibility Center, Hippokration General Hospital, Thessaloniki, Greece; Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece; 'A' Intensive Care Unit, George Papanikolaou Hospital, Thessaloniki, Greece; 'B' Intensive Care Unit, George Papanikolaou Hospital, Thessaloniki, Greece; Department of Anesthesiology, George Papanikolaou Hospital, Thessaloniki, Greece; ECONCARE LP, Athens, Greece; Department of Nursing, University of Peloponnese, Tripolis, Greece; Euromedica Arogi Rehabilitation Center, Thessaloniki, Greece; Department of Respiratory Failure, George Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2nd Propedeutic Department of Internal Medicine, Hippokrateio Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Microbiology, George Papanikolaou Hospital, Thessaloniki, Greece; National and Kapodistrian University of Athens, Evaggelismos General Hospital, Athens, Greece; Hematopoietic Cell Transplantation Unit, Department of Hematology Gene and Cell Therapy Center, George Papanikolaou Hospital, Thessaloniki, Greece; Department of Medicine, University of Washington, Seattle, WA, USA. Nature Medicine (2023), Doi: 10.1038/s41591-023-02480-8.
374. SARS-CoV-2-Specific CD8+ T Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after Infection. Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti and Maurizio Federico. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy; National Center for Animal Experimentation and Welfare, Istituto Superiore di Sanità, Rome, Italy. Doi: 10.20944/preprints202307.2115.v1.
375. Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus. Soon-Oh Hong, Joonsung Kim, Sungmin Lee, Jaeil Shin, Hwanjun Choi, Eunjin Lee, Hyesoo Kang, Hyesun Lee, Soondong Lee,1 Naeun Yun, Jiwon An, Heonsik Choi, Hyeree Kim, Wonseok Kang, Yeup Yoon and Sujeong Kim. Institute of BioInnovation Research, Kolon Life Science, Seoul, Republic of Korea; epartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea; Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, SeoulKorea; Department of Biopharmaceutical Convergence, Sungkyunkwan University, SuwonRepublic of Korea. Molecular Therapy Oncolytics, DOI: 10.1016/j.omto.2023.08.013.
376. Type 2 T cell responses against distinct epitopes of the desmoglein 3 ectodomain in pemphigus vulgaris.Dario Didona, Luca Scarsella, Christoph Hudemann, Karolin Volkmann, Christine L. Zimmer, Benedikt Beckert, Ritva Tikkanen, Vera Korff, Katja Kühn, Sandra Wienzek-Lischka, Gregor Bein, Giovanni di Zenzo, Jaqueline Böhme, Tomas Cunha, Farzan Solimani, Josquin Pieper, Hazem A. Juratli, Manuel Göbel, Thomas Schmidt, Luca Borradori, Amir S. Yazdi Cassian Sitaru, Holger Garn, Rüdiger Eming, Sabine Fleischer and Michael Hertl. Department of Dermatology and Allergology, Philipps University, Marburg, Germany; Institute of Biochemistry, Medical Faculty, University of Giessen, Germany; Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany; Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata (IDI), IRCCS, Rome, Italy; Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, Berlin, Germany; Department of Dermatology, University Hospital Basel, Switzerland; Department of Dermatology, University of Bern, Switzerland; Department of Dermatology, RWTH Aachen, Germany; Department of Dermatology, Albert-Ludwigs Univerity, Freiburg, Germany; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Philipps University, Marburg, Germany; Klinik III Dermatologie, Venerologie & Allergologie, Bundeswehrzentralkrankenhaus Koblenz, Koblenz, Germany. Topas Therapeutics, Hamburg, Germany. DOI: 10.1016/j.jid.2023.07.025.
377. Immune Profile Determines Response to Vaccination against COVID-19 in Kidney Transplant Recipients. Stamatia Stai, Asimina Fylaktou, Efstratios Kasimatis, Aliki Xochelli, Georgios Lioulios, Vasiliki Nikolaidou, Anastasia Papadopoulou, Grigorios Myserlis, Artemis Maria Iosifidou, Myrto Aikaterini Iosifidou, Aikaterini Papagianni, Evangelia Yannaki, Georgios Tsoulfas and Maria Stangou. School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; Department of Nephrology, Hippokration Hospital, Thessaloniki, Greece; Department of Immunology, National Histocompatibility Center, Hippokration General Hospital, Thessaloniki, Greece; Hematology Department, Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, “George Papanikolaou” Hospital, Thessaloniki, Greece; Department of Transplant Surgery, Hippokration General Hospital, Thessaloniki, Greece. Vaccines 2023, 11(10), 1583, Doi: 10.3390/vaccines11101583.
378. Humoral and Cellular Immunity Are Significantly Affected in Renal Transplant Recipients, following Vaccination with BNT162b2. Asimina Fylaktou, Stamatia Stai, Efstratios Kasimatis, Aliki Xochelli, Vasiliki Nikolaidou, Anastasia Papadopoulou, Grigorios Myserlis, Georgios Lioulios, Despoina Asouchidou, Maria Giannaki, Evangelia Yannaki, Georgios Tsoulfas, Aikaterini Papagianni and Maria Stangou. Department of Immunology, National Histocompatibility Center, Hippokration General Hospital, Thessaloniki, Greece; Department of Nephrology, Hippokration Hospital, Thessaloniki, Greece; School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; Hematology Department-Hematopoietic Cell Transplantation Unit, Gene and Cell Therapy Center, “George Papanikolaou” Hospital, hessaloniki, Greece; Department of Transplant Surgery, Hippokration Hospital, Thessaloniki, Greece. Vaccines 2023, 11(11), 1670; DOI: 10.3390/vaccines11111670.
